Abstract
Based on data from 76 informative families, linkages between Pa and Pr and between Pr and Db have been established by two-point linkage analysis. In both pairs of loci, there were no significant sex heterogeneity in recombination fractions. Linkage between Pa and Db cannot be established based on two-point analyses, but a significant sex difference in the recombination fraction between Pa and Db was observed. Strong confirming evidence was obtained from three-point analysis to place Pa, Pr, and Db in one linkage group. The most likely order is Pa-Pr-Db, but the relative odds over second order Pr-Pa-Db are small. Haplotype frequencies of Pr, Pa, and Db were obtained based on the phenotypes of the 685 random Caucasians, providing evidence for marked linkage disequilibrium among the three loci.
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