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. 1993 Jun;34(6):360–364.

Relationship of serum total calcium to serum albumin in dogs, cats, horses and cattle

Dorothee Bienzle, Robert M Jacobs, John H Lumsden
PMCID: PMC1686560  PMID: 17424241

Abstract

A retrospective study was performed in order to assess the relationship between serum calcium and serum albumin concentrations in domestic animals. Results of 9041 canine, 1564 feline, 2917 equine, and 613 bovine serum samples from hospitalized patients were examined by regression analysis. Subpopulations of cases with concurrent elevations in creatinine or that were less than six months of age were evaluated separately. Statistically significant linear relationships between calcium and albumin concentrations were established for each species (p <0.05). The coefficients of determination (r2) were 0.169 for dogs, 0.294 for cats, 0.222 for horses, and 0.032 for cattle. The correlation coefficients (r) computed were: dogs = 0.411, cats = 0.543, horses = 0.471, cattle = 0.182. Neither increases in creatinine concentration nor juvenile age appreciably influenced the relationship between calcium and albumin concentrations. Interspecies variation was marked, and a strong correlation between calcium and albumin concentrations was not established in any species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Besarab A., Caro J. F. Increased absolute calcium binding to albumin in hypoalbuminaemia. J Clin Pathol. 1981 Dec;34(12):1368–1374. doi: 10.1136/jcp.34.12.1368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Besarab A., DeGuzman A., Swanson J. W. Effect of albumin and free calcium concentrations on calcium binding in vitro. J Clin Pathol. 1981 Dec;34(12):1361–1367. doi: 10.1136/jcp.34.12.1361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bowers G. N., Jr, Brassard C., Sena S. F. Measurement of ionized calcium in serum with ion-selective electrodes: a mature technology that can meet the daily service needs. Clin Chem. 1986 Aug;32(8):1437–1447. [PubMed] [Google Scholar]
  4. Busdan H., Rapoport A., Locke S. Influence of posture on the serum concentration of calcium. Metabolism. 1973 Jun;22(6):787–797. doi: 10.1016/0026-0495(73)90049-8. [DOI] [PubMed] [Google Scholar]
  5. Contreras P. A., Manston R., Sansom B. F. Calcium mobilisation in hypomagnesaemic cattle. Res Vet Sci. 1982 Jul;33(1):10–16. [PubMed] [Google Scholar]
  6. Drazner F. H. Hypercalcemia in the dog and cat. J Am Vet Med Assoc. 1981 Jun 15;178(12):1252–1256. [PubMed] [Google Scholar]
  7. Flanders J. A., Scarlett J. M., Blue J. T., Neth S. Adjustment of total serum calcium concentration for binding to albumin and protein in cats: 291 cases (1986-1987). J Am Vet Med Assoc. 1989 Jun 1;194(11):1609–1611. [PubMed] [Google Scholar]
  8. Fogh-Andersen N. Albumin/calcium association at different pH, as determined by potentiometry. Clin Chem. 1977 Nov;23(11):2122–2126. [PubMed] [Google Scholar]
  9. Kohn C. W., Brooks C. L. Failure of pH to predict ionized calcium percentage in healthy horses. Am J Vet Res. 1990 Aug;51(8):1206–1210. [PubMed] [Google Scholar]
  10. Lincoln S. D., Lane V. M. Serum ionized calcium concentration in clinically normal dairy cattle, and changes associated with calcium abnormalities. J Am Vet Med Assoc. 1990 Dec 1;197(11):1471–1474. [PubMed] [Google Scholar]
  11. Meuten D. J., Chew D. J., Capen C. C., Kociba G. J. Relationship of serum total calcium to albumin and total protein in dogs. J Am Vet Med Assoc. 1982 Jan 1;180(1):63–67. [PubMed] [Google Scholar]
  12. Meuten D. J. Hypercalcemia. Vet Clin North Am Small Anim Pract. 1984 Jul;14(4):891–910. doi: 10.1016/s0195-5616(84)50088-6. [DOI] [PubMed] [Google Scholar]
  13. Tennant B., Bettleheim P., Kaneko J. J. Paradoxic hypercalcemia and hypophosphatemia associated with chronic renal failure in horses. J Am Vet Med Assoc. 1982 Mar 15;180(6):630–634. [PubMed] [Google Scholar]
  14. Weir E. C., Norrdin R. W., Matus R. E., Brooks M. B., Broadus A. E., Mitnick M., Johnston S. D., Insogna K. L. Humoral hypercalcemia of malignancy in canine lymphosarcoma. Endocrinology. 1988 Feb;122(2):602–608. doi: 10.1210/endo-122-2-602. [DOI] [PubMed] [Google Scholar]

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