Abstract
The hypotensive activity of five beta-adrenoceptor antagonists with different ancillary pharmacological properties was compared in a randomised double-blind factorial trial in 25 untreated patients with stable, uncomplicated essential hypertension. In doses that produced similar reductions in exercise tachycardia all drugs had similar blood-pressure lowering activity, greater on systolic than diastolic pressure and greatest during exercise. With the exception of vasodilator activity the possession of any particular combinaton of ancillary pharmacological properties did not significantly influence the specific antihypertensive activity of these compounds.
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Selected References
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- Leishman A. W., Thirkettle J. L., Allen B. R., Dixon R. A. Controlled trial of oxprenolol and practolol in hypertension. Br Med J. 1970 Nov 7;4(5731):342–344. doi: 10.1136/bmj.4.5731.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sokolow M., Werdegar D., Kain H. K., Hinman A. T. Relationship between level of blood pressure measured casually and by portable recorders and severity of complications in essential hypertension. Circulation. 1966 Aug;34(2):279–298. doi: 10.1161/01.cir.34.2.279. [DOI] [PubMed] [Google Scholar]
- Thadani U., Sharma B., Meeran M. K., Majid P. A., Whitaker W., Taylor S. H. Comparison of adrenergic beta-receptor antagonists in angina pectoris. Br Med J. 1973 Jan 20;1(5846):138–142. doi: 10.1136/bmj.1.5846.138. [DOI] [PMC free article] [PubMed] [Google Scholar]