Abstract
High remission rates have been produced by MOPP (mustine, vincristine, procarbazine, and prednisone) chemotherapy in patients with advanced Hodgkin's disease, but the prednisone component has caused adverse effects in patients who have undergone radiotherapy. The remission rates and length of remission were reviewed in 211 patients with Hodgkin's disease who received chemotherapy either with or without prednisone. In contrast to the findings of a British study, there were no significant differences in remission rates or length of remission between patients who had received prednisone and patients who had not. There were differences between the British prospective study and this retrospective one, but it is difficult to know what accounted for the substantial differences in the findings.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Castellino R. A., Glatstein E., Turbow M. M., Rosenberg S., Kaplan H. S. Latent radiation injury of lungs or heart activated by steroid withdrawal. Ann Intern Med. 1974 May;80(5):593–599. doi: 10.7326/0003-4819-80-5-593. [DOI] [PubMed] [Google Scholar]
- Devita V. T., Jr, Serpick A. A., Carbone P. P. Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med. 1970 Dec;73(6):881–895. doi: 10.7326/0003-4819-73-6-881. [DOI] [PubMed] [Google Scholar]
- GEHAN E. A. A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES. Biometrika. 1965 Jun;52:203–223. [PubMed] [Google Scholar]
- Moore M. R., Jones S. E., Bull J. M., William L. A., Rosenberg S. A. MOPP chemotherapy for advanced Hodgkin's disease. Prognostic factors in 81 patients. Cancer. 1973 Jul;32(1):52–60. doi: 10.1002/1097-0142(197307)32:1<52::aid-cncr2820320107>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]