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Philosophical Transactions of the Royal Society B: Biological Sciences logoLink to Philosophical Transactions of the Royal Society B: Biological Sciences
. 2004 Aug 29;359(1448):1269-75; discussion 1275, 1323-8. doi: 10.1098/rstb.2004.1503

The effect of water on protein dynamics.

G Zaccai 1
PMCID: PMC1693409  PMID: 15306381

Abstract

Neutron diffraction and spectroscopy were applied to describe the hydration and dynamics of a soluble protein and a natural membrane from extreme halophilic Archaea. The quantitative dependence of protein motions on water activity was clearly illustrated, and it was established that a minimum hydration shell is required for the systems to access their functional resilience, i.e. a dynamics state that allows biological activity.

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Selected References

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