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. 1970 Feb 28;1(5695):519–523. doi: 10.1136/bmj.1.5695.519

Surgical Treatment of Thyrotoxicosis

Anthony J Hedley, Christopher J Flemming, Marian I Chesters, W Michie, James Crooks
PMCID: PMC1699520  PMID: 4190906

Abstract

A retrospective study of thyrotoxic patients treated by subtotal thyroidectomy between 2 and 21 years ago in the north-east of Scotland showed that 20% of the patients could not be identified or traced at the time of the survey. The thyroid status of 40% of patients followed up was abnormal.

It is now accepted that radioiodine treatment of thyrotoxicosis is followed by a significant incidence of late onset hypothyroidism, and life-long follow-up is regarded as obligatory. The findings in this study indicate that similar methods of aftercare are required for surgically treated patients and for all patients receiving thyroxine-replacement therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BELING U., EINHORN J. Incidence of hypothyroidism and recurrences following I-131 treatment of hyperthyroidism. Acta radiol. 1961 Oct;56:275–288. doi: 10.3109/00016926109172822. [DOI] [PubMed] [Google Scholar]
  2. BLACKBURN G. Surgery in thyroid disease. Trans Med Soc Lond. 1961;78:105–139. [PubMed] [Google Scholar]
  3. BLOMFIELD G. W., ECKERT H., FISHER M., MILLER H., MUNRO D. S., WILSON G. M. Treatment of thyrotoxicosis with 131 I; a review of 500 cases. Br Med J. 1959 Jan 10;1(5114):63–74. doi: 10.1136/bmj.1.5114.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Billewicz W. Z., Chapman R. S., Crooks J., Day M. E., Gossage J., Wayne E., Young J. A. Statistical methods applied to the diagnosis of hypothyroidism. Q J Med. 1969 Apr;38(150):255–266. [PubMed] [Google Scholar]
  5. Bonnar J., Goldberg A., Smith J. A. Do pregnant women take their iron? Lancet. 1969 Mar 1;1(7592):457–458. doi: 10.1016/s0140-6736(69)91492-5. [DOI] [PubMed] [Google Scholar]
  6. Bowers R. F. Surgical treatment of hyperthyroidism. Follow up of 103 cases. Am Surg. 1966 Feb;32(2):89–95. [PubMed] [Google Scholar]
  7. Bronsky D., Kiamko R. T., Waldstein S. S. Posttherapeutic myxedema. Relative occurrence after treatment of hyperthyroidism by radioactive iodine (131-I) or subtotal thyroidectomy. Arch Intern Med. 1968 Feb;121(2):113–117. doi: 10.1001/archinte.121.2.113. [DOI] [PubMed] [Google Scholar]
  8. CLARK F., HORN D. B. ASSESSMENT OF THYROID FUNCTION BY THE COMBINED USE OF THE SERUM PROTEIN-BOUND IODINE AND RESIN UPTAKE OF 131-I-TRIIODOTHYRONINE. J Clin Endocrinol Metab. 1965 Jan;25:39–45. doi: 10.1210/jcem-25-1-39. [DOI] [PubMed] [Google Scholar]
  9. CRILE G., Jr, McCULLAGH E. P. The treatment of hyperthyroidism; an evaluation of thyroidectomy, of prolonged administration of propyl thiouracil, and of radioactive iodine. Ann Surg. 1951 Jul;134(1):18–28. doi: 10.1097/00000658-195107000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. CROOKS J., WAYNE E. J., ROBB R. A. A clinical method of assessing the results of therapy in thyrotoxicosis. Lancet. 1960 Feb 20;1(7121):397–401. doi: 10.1016/s0140-6736(60)90334-2. [DOI] [PubMed] [Google Scholar]
  11. FARRELL L. P., RICHMOND M. H. A rapid method for the estimation of serum protein-bound iodine. Clin Chim Acta. 1961 Sep;6:620–623. doi: 10.1016/0009-8981(61)90104-8. [DOI] [PubMed] [Google Scholar]
  12. GREENE R. The significance of lymphadenoid changes in the thyroid gland. J Endocrinol. 1950 Nov;7(1):1–6. doi: 10.1677/joe.0.0070001. [DOI] [PubMed] [Google Scholar]
  13. GREEN M., WILSON G. M. THYROTOXICOSIS TREATED BY SURGERY OR IODINE-131. WITH SPECIAL REFERENCE TO DEVELOPMENT OF HYPOTHYROIDISM. Br Med J. 1964 Apr 18;1(5389):1005–1010. doi: 10.1136/bmj.1.5389.1005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Greig W. R. Radiation, thyroid cells and 131-I therapy--a hypothesis. J Clin Endocrinol Metab. 1965 Oct;25(10):1411–1417. doi: 10.1210/jcem-25-10-1411. [DOI] [PubMed] [Google Scholar]
  15. HOBBS J. R., BAYLISS R. I., MACLAGAN N. F. The routine use of 132-I in the diagnosis of thyroid disease. Lancet. 1963 Jan 5;1(7271):8–13. doi: 10.1016/s0140-6736(63)91143-7. [DOI] [PubMed] [Google Scholar]
  16. McLarty D. G., Alexander W. D., Harden R. M., Clark D. H. Results of treatment of thyrotoxicosis after postoperative relapse. Br Med J. 1969 Jul 26;3(5664):200–203. doi: 10.1136/bmj.3.5664.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. McNeill A. D., Thomson J. A. Long-term follow-up of surgically treated thyrotoxic patients. Br Med J. 1968 Sep 14;3(5619):643–646. doi: 10.1136/bmj.3.5619.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Murley R. S., Rigg B. M. Postoperative thyroid function and complications in relation to a measured thyroid remnant. Br J Surg. 1968 Oct;55(10):757–760. doi: 10.1002/bjs.1800551011. [DOI] [PubMed] [Google Scholar]
  19. Nofal M. M., Beierwaltes W. H., Patno M. E. Treatment of hyperthyroidism with sodium iodide I-131. JAMA. 1966 Aug 22;197(8):605–610. [PubMed] [Google Scholar]
  20. PAINTER N. S. The results of surgery in the treatment of toxic goitre. A review of 172 cases. Br J Surg. 1960 Nov;48:291–296. doi: 10.1002/bjs.18004820910. [DOI] [PubMed] [Google Scholar]
  21. Philp J. R., Duthie M. B., Crooks J. A follow-up scheme for detecting hypothyroidism in thyrotoxic patients treated with radioiodine. Lancet. 1968 Dec 21;2(7582):1336–1338. doi: 10.1016/s0140-6736(68)91830-8. [DOI] [PubMed] [Google Scholar]
  22. Plested W. G., 3rd, Pollock W. F. Radioactive iodine, antithyroid drugs, and surgery in treatment of hyperthyroidism. Arch Surg. 1967 Apr;94(4):517–523. doi: 10.1001/archsurg.1967.01330100081013. [DOI] [PubMed] [Google Scholar]
  23. Porter A. M. Drug defaulting in a general practice. Br Med J. 1969 Jan 25;1(5638):218–222. doi: 10.1136/bmj.1.5638.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. RIDDELL V. Thyrotoxicosis and the surgeon. Br J Surg. 1962 Mar;49:465–496. doi: 10.1002/bjs.18004921702. [DOI] [PubMed] [Google Scholar]
  25. Roy A. D., Allan J., Harden R. M. A follow-up of thyrotoxic patients treated by partial thyroidectomy. Lancet. 1967 Sep 30;2(7518):684–688. doi: 10.1016/s0140-6736(67)90973-7. [DOI] [PubMed] [Google Scholar]
  26. WHITESELL F. B., Jr, BLACK B. M. A statistical study of the clinical significance of lymphocytic and fibrocytic replacements in the hyperplastic thyroid gland. J Clin Endocrinol Metab. 1949 Nov;9(11):1202-15, illust. doi: 10.1210/jcem-9-11-1202. [DOI] [PubMed] [Google Scholar]

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