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. 1970 Apr 18;2(5702):131–136. doi: 10.1136/bmj.2.5702.131

Bone Marrow Graft in Man after Conditioning by Antilymphocytic Serum*

G Mathé, J L Amiel, L Schwarzenberg, J Choay, P Trolard, M Schneider, M Hayat, J R Schlumberger, Cl Jasmin
PMCID: PMC1699952  PMID: 4909449

Abstract

Allogeneic bone marrow grafts carried out after previous administration of antilymphocytic serum alone were attempted in 16 patients. Of these, six had acute myeloblastic leukaemia, four acute lymphoblastic leukaemia, and one a blast cell crisis in polycythaemia vera. Ten of these patients were in an overt phase of the disease and resistant to chemotherapy, while nine had complete agranulocytosis. In five of these patients erythrocyte and leucocyte antigenic markers demonstrated the establishment of the graft. One patient had thalassaemia major, and four others had aplasia of the bone marrow, in one case due to chloramphenicol poisoning and in another to virus hepatitis. The grafts were successful in the last two patients and transformed their clinical condition.

No signs of early acute secondary disease were noted in any of the patients, either when the donor had been given antilymphocytic serum or when he was untreated. The grafts had no adoptive immunotherapeutic effect on the acute leukaemia. These observations have clearly shown that antilymphocytic serum has an immunosuppressive effect in man when it is used alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach F. H., Albertini R. J., Joo P., Anderson J. L., Bortin M. M. Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet. 1968 Dec 28;2(7583):1364–1366. doi: 10.1016/s0140-6736(68)92672-x. [DOI] [PubMed] [Google Scholar]
  2. Bach J. F., Dardenne M., Antoine B. Un noveau test d'activité des sérums antilymphocytes: l'inhibition du phénomène des rosettes. Pathol Biol. 1968 Jun-Jul;16(11):657–662. [PubMed] [Google Scholar]
  3. Gatti R. A., Meuwissen H. J., Allen H. D., Hong R., Good R. A. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet. 1968 Dec 28;2(7583):1366–1369. doi: 10.1016/s0140-6736(68)92673-1. [DOI] [PubMed] [Google Scholar]
  4. MATHE G., AMIEL J. L., DAGUET G. [Study of serum agglutinins against a bacterial antigen in hematological radiochimerae immunized against the antigen before irradiation]. Nouv Rev Fr Hematol. 1961 Jan-Feb;1:65–71. [PubMed] [Google Scholar]
  5. MATHE G., AMIEL J. L., SCHWARZENBERG L., CATTAN A., SCHNEIDER M., DEVRIES M. J., TUBIANA M., LALANNE C., BINET J. L., PAPIERNIK M. SUCCESSFUL ALLOGENIC BONE MARROW TRANSPLANTATION IN MAN: CHIMERISM, INDUCED SPECIFIC TOLERANCE AND POSSIBLE ANTI-LEUKEMIC EFFECTS. Blood. 1965 Feb;25:179–196. [PubMed] [Google Scholar]
  6. MATHE G., AMIEL J. L., SCHWARZENBERG L., CATTAN A., SCHNEIDER M. HAEMATOPOIETIC CHIMERA IN MAN AFTER ALLOGENIC (HOMOLOGOUS) BONE-MARROW TRANSPLANTATION. (CONTROL OF THE SECONDARY SYNDROME. SPECIFIC TOLERANCE DUE TO THE CHIMERISM). Br Med J. 1963 Dec 28;2(5373):1633–1635. doi: 10.1136/bmj.2.5373.1633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mathé G., Amiel J. L., Schwarzenberg L., Schneider M., Cattan A., Schlumberger J. R., Hayat M., De Vassal F. Active immunotherapy for acute lymphoblastic leukaemia. Lancet. 1969 Apr 5;1(7597):697–699. doi: 10.1016/s0140-6736(69)92648-8. [DOI] [PubMed] [Google Scholar]
  8. Meuwissen H. J., Good R. A. Bone marrow transplantation in lymphopenic immunological deficiency disease. Rev Eur Etud Clin Biol. 1970 Feb;15(2):151–154. [PubMed] [Google Scholar]
  9. Schwarzenberg L., Cattan A., Schneider M., Schlumberger J. R., Amiel J. L., Mathé G. La "réanimation hématologique". II. Correction des désordres graves des leucocytes et des immunoglobulines. La greffe de moelle osseuse. Presse Med. 1966 Apr 23;74(21):1061–1065. [PubMed] [Google Scholar]
  10. Schwarzenberg L., Nagi N. S., Pradet-Balade O., Mathé G. Utilisation pour la séparation des lymphocytes sanguins du séparateur de cellules sanguines a débit continu. Nouv Rev Fr Hematol. 1968 Sep-Oct;8(5):579–584. [PubMed] [Google Scholar]
  11. Seller M. J., Polani P. E. Transplantation of allogeneic haemopoietic tissue in adult anaemic mice of the W series using antilymphocytic serum. Lancet. 1969 Jan 4;1(7584):18–21. doi: 10.1016/s0140-6736(69)90985-4. [DOI] [PubMed] [Google Scholar]
  12. THOMAS E. D., KASAKURA S., CAVINS J. A., FERREBEE J. W. MARROW TRANSPLANTS IN LETHALLY IRRADIATED DOGS: THE EFFECT OF METHOTREXATE ON SURVIVAL OF THE HOST AND THE HOMOGRAFT. Transplantation. 1963 Oct;1:571–574. doi: 10.1097/00007890-196301040-00018. [DOI] [PubMed] [Google Scholar]
  13. UPHOFF D. E. Alteration of homograft reaction by A-methopterin in lethally irradiated mice treated with homologous marrow. Proc Soc Exp Biol Med. 1958 Dec;99(3):651–653. doi: 10.3181/00379727-99-24450. [DOI] [PubMed] [Google Scholar]

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