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British Medical Journal logoLink to British Medical Journal
. 1970 Jul 4;3(5713):7–10. doi: 10.1136/bmj.3.5713.7

Combination Chemotherapy in Generalized Hodgkin's Disease

W M Nicholson, M E J Beard, D Crowther, A G Stansfeld, C P Vartan, J S Malpas, G Hamilton Fairley, Ronald Bodley Scott
PMCID: PMC1701007  PMID: 5427500

Abstract

Fifty-two patients with generalized Hodgkin's disease were treated with a combination of mustine hydrochloride, vinblastine, procarbazine, and prednisolone. Complete remissions were obtained initially in six out of seven patients (86%) who had previously received no treatment, in 15 out of 19 (79%) who had had only radiotherapy in the past, and in 9 out of 26 (35%) who had previously been given chemotherapy with or without radiotherapy. Of these 30 patients in whom a complete remission was obtained 22 have been free of any symptoms or signs of disease for periods ranging from 4 to 22 months. The response to treatment was rapid, and toxicity was not a major problem, except in those who had previously been treated with cytotoxic drugs used continuously and not in courses. A comparative trial of radiotherapy and combination therapy in the treatment of Stage III Hodgkin's disease is strongly recommended.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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