Abstract
In a clinical trial on 220 patients with bacteriologically proved enteric fever trimethoprim-sulphamethoxazole was compared with chloramphenicol. All patients in both groups responded, and the mean periods of defervescence after starting therapy were similar in both groups. Trimethoprim-sulphamethoxazole was much superior to chloramphenicol in rapidity and uniformity of relief of toxaemia. “Toxic crisis” occurred in 10 out of 120 patients in the chloramphenicol group and was absent in the trimethoprim-sulphamethoxazole group. No major side-effects due to specific drug therapy were observed in either group.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Akinkugbe O. O., Lewis E. A., Montefiore D., Okubadejo O. A. Trimethoprim and sulphamethoxazole in typhoid. Br Med J. 1968 Sep 21;3(5620):721–722. doi: 10.1136/bmj.3.5620.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brauer M. J., Dameshek W. Hypoplastic anemia and myeloblastic leukemia following chloramphenicol therapy. Report of three cases. N Engl J Med. 1967 Nov 9;277(19):1003–1005. doi: 10.1056/NEJM196711092771904. [DOI] [PubMed] [Google Scholar]
- Dunkerley G. E. Perforation of the Ileum in Enteric Fever. Br Med J. 1946 Sep 28;2(4473):454–457. [PMC free article] [PubMed] [Google Scholar]
- KOSTIC A. LE PROBL'EME DES FI'EVRES TYPHOUIDES A S'ERO-DIAGNOSTIC N'EGATIF. Presse Med. 1963 Dec 7;71:2489–2492. [PubMed] [Google Scholar]
- Kamat S. A. Furazolidone in treatment of salmonellosis. JAMA. 1968 Dec 16;206(12):2745–2745. [PubMed] [Google Scholar]
- Robertson R. P., Wahab M. F., Raasch F. O. Evaluation of chloramphenicol and ampicillin in salmonella enteric fever. N Engl J Med. 1968 Jan 25;278(4):171–176. doi: 10.1056/NEJM196801252780401. [DOI] [PubMed] [Google Scholar]
- SINGH B., SAXENA S. N. SINGLE WIDAL TEST IN CULTURE-POSITIVE CASES OF ENTERIC GROUP OF FEVERS. J Assoc Physicians India. 1964 Dec;12:831–837. [PubMed] [Google Scholar]