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. 1970 Sep 5;3(5722):554–556. doi: 10.1136/bmj.3.5722.554

Benign Intracranial Hypertension following Corticosteroid Withdrawal in Childhood

B G R Neville, J Wilson
PMCID: PMC1701594  PMID: 4318283

Abstract

In an 18-month period seven children who were treated for a variety of neurological and non-neurological diseases, and in whom the corticosteroid or corticotrophin dosage was reduced, developed a syndrome indistinguishable from “benign intracranial hypertension.” The total duration and rate of reduction of corticosteroid dosage and perhaps an underlying susceptibility to cerebral oedema appear to be important factors in this syndrome. Usually patients can be treated without the need for special neuroradiological studies. Possibly mild forms of this condition are not uncommon, but its pathogenesis is still uncertain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DEES S. C., McKAY H. W., Jr Occurrence of pseudotumor cerebri (benign intracranial hypertension) during treatment of children with asthma by adrenal steroids; report of three cases. Pediatrics. 1959 Jun;23(6):1143–1151. [PubMed] [Google Scholar]
  2. Eiben R. M. Acute brain swelling (toxic encephalopathy). Pediatr Clin North Am. 1967 Nov;14(4):797–808. doi: 10.1016/s0031-3955(16)32056-9. [DOI] [PubMed] [Google Scholar]
  3. FREYBERG R. H., BERNTSEN C. A., Jr, HELLMAN L. Further experiences with delta 1,9 alpha fluoro, 16 alpha hydroxyhydrocortisone (triamcinolone) in treatment of patients with rheumatoid arthritis. Arthritis Rheum. 1958 Jun;1(3):215–229. doi: 10.1002/art.1780010304. [DOI] [PubMed] [Google Scholar]
  4. GERBER A., RAAB A. P., SOBEL A. E. Vitamin A poisoning in adults; with description of a case. Am J Med. 1954 May;16(5):729–745. doi: 10.1016/0002-9343(54)90281-8. [DOI] [PubMed] [Google Scholar]
  5. GREER M. BENIGN INTRACRANIAL HYPERTENSION. III. PREGNANCY. Neurology. 1963 Aug;13:670–672. doi: 10.1212/wnl.13.8.670. [DOI] [PubMed] [Google Scholar]
  6. GREER M. BENIGN INTRACRANIAL HYPERTENSION. IV. MENARCHE. Neurology. 1964 Jun;14:569–573. doi: 10.1212/wnl.14.6.569. [DOI] [PubMed] [Google Scholar]
  7. GREER M. BENIGN INTRACRANIAL HYPERTENSION. V. MENSTRUAL DYSFUNCTION. Neurology. 1964 Jul;14:668–673. doi: 10.1212/wnl.14.7.668. [DOI] [PubMed] [Google Scholar]
  8. GREER M. Benign intracranial hypertension. I. Mastoiditis and lateral sinus obstruction. Neurology. 1962 Jul;12:472–476. doi: 10.1212/wnl.12.7.472. [DOI] [PubMed] [Google Scholar]
  9. GREER M. Benign intracranial hypertension. II. Following corticosteroid therapy. Neurology. 1963 May;13:439–441. doi: 10.1212/wnl.13.5.439. [DOI] [PubMed] [Google Scholar]
  10. LEEKSMA C. H., DE GRAEFF J., DE COCK J. Hypercalcaemia in adrenal insufficiency. Acta Med Scand. 1957 Feb 2;156(6):455–458. doi: 10.1111/j.0954-6820.1957.tb00102.x. [DOI] [PubMed] [Google Scholar]
  11. SUGAR O. Central neurological complications of hypoparathyroidism. AMA Arch Neurol Psychiatry. 1953 Jul;70(1):86–107. doi: 10.1001/archneurpsyc.1953.02320310092008. [DOI] [PubMed] [Google Scholar]
  12. SYMONDS C. Intracranial thrombophlebitis. Ann R Coll Surg Engl. 1952 Jun;10(6):347–356. [PMC free article] [PubMed] [Google Scholar]
  13. VALENTINE G. H. Triamcinolone and intracranial hypertension: a side-effect. Lancet. 1959 Apr 25;1(7078):892–892. doi: 10.1016/s0140-6736(59)91983-x. [DOI] [PubMed] [Google Scholar]

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