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. 1970 Sep 26;3(5725):737–740. doi: 10.1136/bmj.3.5725.737

Large-scale Digitoxin Intoxication

A H Lely, C H J Van Enter
PMCID: PMC1701634  PMID: 5273245

Abstract

Because of an error in the manufacture of digoxin tablets a large number of patients took tablets that contained 0·20 mg. of digitoxin and 0·05 mg. of digoxin instead of the prescribed 0·25 mg. of digoxin. The symptoms are described of 179 patients who took these tablets and suffered from digitalis intoxication. Of these patients, 125 had taken the faultily composed tablets for more than three weeks. In 48 patients 105 separate disturbances in rhythm or in atrioventricular conduction were observed on the electrocardiogram. Extreme fatigue and serious eye conditions were observed in 95% of the patients. Twelve patients had a transient psychosis. Extensive ophthalmological observations indicated that the visual complaints were most probably caused by a transient retrobulbar neuritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHURCH G., MARRIOTT H. J. Digitalis delirium: a report on three cases. Circulation. 1959 Oct;20:549–553. doi: 10.1161/01.cir.20.4.549. [DOI] [PubMed] [Google Scholar]
  2. CHURCH G., SCHAMROTH L., SCHWARTZ N. L., MARRIOTT H. J. Deliberate digitalis intoxication. A comparison of the toxic effects of four glycoside preparations. Ann Intern Med. 1962 Dec;57:946–956. doi: 10.7326/0003-4819-57-6-946. [DOI] [PubMed] [Google Scholar]
  3. CROUCH R. B., HEJTMANCIK M. R., HERRMANN G. R. Digitalis intoxication. Tex State J Med. 1956 Oct;52(10):714–718. [PubMed] [Google Scholar]
  4. Cozijnsen M., Pinckers A. J. Oogheelkundige aspecten van digitoxine-intoxicatie. Ned Tijdschr Geneeskd. 1969 Oct 4;113(40):1735–1737. [PubMed] [Google Scholar]
  5. DUBNOW M. H., BURCHELL H. B. A COMPARISON OF DIGITALIS INTOXICATION IN TWO SEPARATE PERIODS. Ann Intern Med. 1965 May;62:956–965. doi: 10.7326/0003-4819-62-5-956. [DOI] [PubMed] [Google Scholar]
  6. Dall J. L. Digitalis intoxication. Am Heart J. 1965 Oct;70(4):572–574. doi: 10.1016/0002-8703(65)90371-6. [DOI] [PubMed] [Google Scholar]
  7. Gotsman M. S., Schrire V. Toxicity--a frequent complication of digitalis therapy. S Afr Med J. 1966 Jul 9;40(25):590–592. [PubMed] [Google Scholar]
  8. Hurwitz N., Wade O. L. Intensive hospital monitoring of adverse reactions to drugs. Br Med J. 1969 Mar 1;1(5643):531–536. doi: 10.1136/bmj.1.5643.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KING J. T. Digitalis delirium. Ann Intern Med. 1950 Dec;33(6):1360–1372. doi: 10.7326/0003-4819-33-6-1360. [DOI] [PubMed] [Google Scholar]
  10. LOWN B., MARCUS F., LEVINE H. D. Digitalis and atrial tachycardia with block; a year's experience. N Engl J Med. 1959 Feb 12;260(7):301–309. doi: 10.1056/NEJM195902122600701. [DOI] [PubMed] [Google Scholar]
  11. Lely A. H., van Enter C. H., Pool J. Massale digitoxine-intoxicatie. Ned Tijdschr Geneeskd. 1969 Oct 4;113(40):1729–1733. [PubMed] [Google Scholar]
  12. RODENSKY P. L., WASSERMAN F. Observations on digitalis intoxication. Arch Intern Med. 1961 Aug;108:171–188. doi: 10.1001/archinte.1961.03620080003002. [DOI] [PubMed] [Google Scholar]
  13. RODOVA A., HOVOLA D. [On mental disorders in intoxication with Digitalis glycosides]. Cesk Psychiatr. 1959 Dec;55:357–361. [PubMed] [Google Scholar]
  14. Rutledge D. I., Haddad R. Digitalis intoxication: gastrointestinal manifestations. Med Clin North Am. 1966 Mar;50(2):501–506. [PubMed] [Google Scholar]
  15. SCHOELMERICH P., PABST K., JAHRREISS O., LANGE K. P. NEBENWIRKUNGEN DER THERAPIE MIT HERZGLYKOSIDEN. Dtsch Med Wochenschr. 1964 Jan 3;89:12–18. doi: 10.1055/s-0028-1110980. [DOI] [PubMed] [Google Scholar]
  16. Shapiro S., Slone D., Lewis G. P., Jick H. The epidemiology o digoxin. A study in three Boston hospitals. J Chronic Dis. 1969 Nov;22(5):361–371. doi: 10.1016/0021-9681(69)90077-0. [DOI] [PubMed] [Google Scholar]
  17. VON CAPELLER D., COPELAND G. D., STERN T. N. Digitalis intoxication: a clinical report of 148 cases. Ann Intern Med. 1959 Apr;50(4):869–878. doi: 10.7326/0003-4819-50-4-869. [DOI] [PubMed] [Google Scholar]
  18. Weenink H. R., Lely A. H., van Enter C. H. Neuropsychiatrische afwijkingen door digitoxine-intoxicatie. Ned Tijdschr Geneeskd. 1969 Oct 4;113(40):1733–1735. [PubMed] [Google Scholar]

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