Abstract
1. Male and female kittens and adult cats were given p-chlorophenylalanine orally.
2. After treatment, some of the male cats showed mounting behaviour and the kittens and non-oestrous females showed an increase in treading and rubbing which was similar to one aspect of pro-oestrus behaviour.
3. The treated animals also appeared to suffer from skin irritation and showed increased restlessness which accompanied sleep deprivation.
4. Injection of 5-hydroxytryptophan stopped abnormal sexual activity and restored normal sleep for about 5 hours.
5. It is concluded that 5-hydroxytryptamine-containing neurones inhibit sexual behaviour in cats and that this role can be seen in male and, to some extent, also in female animals.
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Selected References
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- Ahtee L., Sharman D. F., Vogt M. Acid metabolites of monoamines in avian brain; effects of probenecid and reserpine. Br J Pharmacol. 1970 Jan;38(1):72–85. doi: 10.1111/j.1476-5381.1970.tb10337.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Airaksinen M. M., McIsaac W. M. Estrus cycle in rats: the role of serotonin and norepinephrine. Life Sci. 1968 May 1;7(9):471–476. doi: 10.1016/0024-3205(68)90049-0. [DOI] [PubMed] [Google Scholar]
- Delorme F., Froment J. L., Jouvet M. Suppression du sommeil par la p. chlorométhamphétamine et la p. chlorophénylalanine. C R Seances Soc Biol Fil. 1966;160(12):2347–2351. [PubMed] [Google Scholar]
- Dement W. C. Recent studies on the biological role of rapid eye movement sleep. Am J Psychiatry. 1965 Oct;122(4):404–408. doi: 10.1176/ajp.122.4.404. [DOI] [PubMed] [Google Scholar]
- Ferguson J., Henriksen S., Cohen H., Mitchell G., Barchas J., Dement W. "Hypersexuality" and behavioral changes in cats caused by administration of p-chlorophenylalanine. Science. 1970 Apr 24;168(3930):499–501. doi: 10.1126/science.168.3930.499. [DOI] [PubMed] [Google Scholar]
- Koe B. K., Weissman A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J Pharmacol Exp Ther. 1966 Dec;154(3):499–516. [PubMed] [Google Scholar]
- Koella W. P., Feldstein A., Czicman J. S. The effect of para-chlorophenylalanine on the sleep of cats. Electroencephalogr Clin Neurophysiol. 1968 Nov;25(5):481–490. doi: 10.1016/0013-4694(68)90158-2. [DOI] [PubMed] [Google Scholar]
- Meyerson B. J. Amphetamine and 5-hydroxytryptamine inhibition of copulatory behaviour in the female rat. Ann Med Exp Biol Fenn. 1968;46(3):394–398. [PubMed] [Google Scholar]
- Sheard M. H. The effect of p-chlorophenylalanine on behavior in rats: relation to brain serotonin and 5-hydroxyindoleacetic acid. Brain Res. 1969 Oct;15(2):524–528. doi: 10.1016/0006-8993(69)90175-9. [DOI] [PubMed] [Google Scholar]
- Shillito E. E. The effect of p-chlorophenylalanine on social interactions of male rats. Br J Pharmacol. 1969 May;36(1):193P–194P. [PMC free article] [PubMed] [Google Scholar]
- Shillito E. E. The effect of parachlorophenylalanine on social interaction of male rats. Br J Pharmacol. 1970 Feb;38(2):305–315. doi: 10.1111/j.1476-5381.1970.tb08518.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tagliamonte A., Tagliamonte P., Gessa G. L., Brodie B. B. Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats. Science. 1969 Dec 12;166(3911):1433–1435. doi: 10.1126/science.166.3911.1433. [DOI] [PubMed] [Google Scholar]
- Tenen S. S. Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor. Psychopharmacologia. 1968;12(4):278–285. doi: 10.1007/BF00401407. [DOI] [PubMed] [Google Scholar]
- Tenen S. S. The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat. Psychopharmacologia. 1967;10(3):204–219. doi: 10.1007/BF00401382. [DOI] [PubMed] [Google Scholar]