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. 1970 May;39(1):128–138. doi: 10.1111/j.1476-5381.1970.tb09562.x

Prejunctional actions of some β-adrenoceptor antagonists in the vas deferens preparation of the guinea-pig

E J Mylecharane, C Raper
PMCID: PMC1703050  PMID: 4392958

Abstract

1. The β-adrenoceptor antagonists propranolol, pronethalol, MJ 1999 and Ciba 39089-Ba reduced responses to field stimulation of the guinea-pig isolated vas deferens preparation without significantly affecting responses to exogenously added noradrenaline.

2. This prejunctional blocking action of the drugs cannot be correlated with their action as β-adrenoceptor antagonists or non-specific depressants.

3. The blockade produced was more pronounced at low (5-20 Hz) than at high (50 Hz) frequencies of stimulation.

4. The blockade was slow in onset, and once established was poorly reversed by washing the preparation over a period of 1 to 2 h.

5. The blockade produced could be reversed by dexamphetamine and cocaine.

6. These experiments suggest that the β-adrenoceptor antagonists may have some actions which closely resemble those of the adrenergic neurone blocking agent guanethidine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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