Inhibition by antihistamines of the vascular permeability increase induced by bradykinin

PMCID: PMC1703335 PMID: 4386856

Abstract

1. Mepyramine and triprolidine hydrochloride have a marked inhibitory effect on the local increase of vascular permeability induced by bradykinin.

2. The anti-bradykinin effect of both antihistamines was species dependent, being evident in rabbits, rats and mice but not in guinea-pigs.

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