Abstract
1. Splanchnic nerve stimulation provokes a larger increase in blood pressure in intact rats than in rats previously demedullated by means of expression of the adrenals in situ and adrenalectomy followed by adrenocortical grafting.
2. Rats pretreated with guanethidine showed an attenuated albeit prolonged hypertensive response to splanchnic stimulation. Similar effects were exerted by guanethidine in rats demedullated by expression. In rats demedullated by grafting, smaller doses of guanethidine induced a more substantial depression of the blood pressure response without increasing its duration.
3. It is concluded that inhibition of the peripheral sympathetic endings induced by guanethidine was partially compensated by the enhancement of the cardiovascular effects of the mediators released by the adrenal medulla and that demedullation by expression did not completely eliminate chromaffin tissue.
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- ABERCROMBIE G. F., DAVIES B. N. The action of guanethidine with particular reference to the sympathetic nervous system. Br J Pharmacol Chemother. 1963 Feb;20:171–177. doi: 10.1111/j.1476-5381.1963.tb01307.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ATHOS W. J., McHUGH B. P., FINEBERG S. E., HILTON J. G. The effects of guanethidine on the adrenal medulla. J Pharmacol Exp Ther. 1962 Aug;137:229–234. [PubMed] [Google Scholar]
- BISCARDI A. M., CARPI A., ORSINGHER O. A. URINARY EXCRETION OF CATECHOL AMINES IN THE RAT AFTER THEIR LIBERATION BY RESERPINE OR DEXAMPHETAMINE. Br J Pharmacol Chemother. 1964 Dec;23:529–539. doi: 10.1111/j.1476-5381.1964.tb01608.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brody M. J. Effect of adrenal demedullation on vascular responses after immunological sympathectomy. Am J Physiol. 1966 Jul;211(1):198–202. doi: 10.1152/ajplegacy.1966.211.1.198. [DOI] [PubMed] [Google Scholar]
- CASS R., SPRIGGS T. L. Tissue amine levels and sympathetic blockade after guanethidine and bretylium. Br J Pharmacol Chemother. 1961 Dec;17:442–450. doi: 10.1111/j.1476-5381.1961.tb01131.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CELANDER O. The range of control exercised by the sympathico-adrenal system; a quantitative study on blood vessels and other smooth muscle effectors in the cat. Acta Physiol Scand Suppl. 1954;32(116):1–132. [PubMed] [Google Scholar]
- CHANG C. C., COSTA E., BRODIE B. B. INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS. J Pharmacol Exp Ther. 1965 Mar;147:303–312. [PubMed] [Google Scholar]
- Costa E., Boullin D. J., Hammer W., Vogel W., Brodie B. B. Interactions of drugs with adrenergic neurons. Pharmacol Rev. 1966 Mar;18(1):577–597. [PubMed] [Google Scholar]
- HILLARP N. A., HOKFELT B. Histochemical demonstration of noradrenaline and adrenaline in the adrenal medulla. J Histochem Cytochem. 1955 Jan;3(1):1–5. doi: 10.1177/3.1.1. [DOI] [PubMed] [Google Scholar]
- MAXWELL R. A., PLUMMER A. J., SCHNEIDER F., POVALSKI H., DANIEL A. I. Pharmacology of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (Su-5864). J Pharmacol Exp Ther. 1960 Jan;128:22–29. [PubMed] [Google Scholar]
- RAMEY E. R., GOLDSTEIN M. S. The adrenal cortex and the sympathetic nervous system. Physiol Rev. 1957 Apr;37(2):155–195. doi: 10.1152/physrev.1957.37.2.155. [DOI] [PubMed] [Google Scholar]
- SKELTON F. R. Adrenal regeneration and adrenal-regeneration hypertension. Physiol Rev. 1959 Jan;39(1):162–182. doi: 10.1152/physrev.1959.39.1.162. [DOI] [PubMed] [Google Scholar]