Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1968 Nov;34(3):623–629. doi: 10.1111/j.1476-5381.1968.tb08491.x

Effect of rabbit antibodies against angiotensin-II on the pressor response to angiotensin-II and renal hypertension in the rat

P R Hedwall
PMCID: PMC1703526  PMID: 4302379

Abstract

1. In the intact or nephrectomized rat, the pressor responses to synthetic angiotensin-II-amide, beta-angiotensin-II and native “rat angiotensin” could be inhibited by intravenous injection of rabbit serum containing antibodies against synthetic angiotensin-II-amide.

2. The pressor responses to vasopressin or noradrenaline were not influenced by anti-angiotensin serum.

3. A single injection of anti-angiotensin serum inhibited the pressor responses to angiotensin-II-amide for a period of 2.5 hr.

4. Intravenous infusion or daily intraperitoneal injection of anti-angiotensin serum did not influence blood pressure levels in renal hypertensive rats.

Full text

PDF
627

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN J. J., CHAPUIS G., ROBERTSON J. I. The effect of long-continued intravenous infusions of angiotensin in the rabbit. Lancet. 1963 Jun 22;1(7295):1356–1357. doi: 10.1016/s0140-6736(63)91930-5. [DOI] [PubMed] [Google Scholar]
  2. BRUNNER H., REGOLI D. [Differential sensitivity of various angiotensin derivatives against decomposition by plasma or kidney homogenates]. Experientia. 1962 Nov 15;18:504–506. doi: 10.1007/BF02151599. [DOI] [PubMed] [Google Scholar]
  3. Byrom F. B., Wilson C. A plethysmographic method for measuring systolic blood pressure in the intact rat. J Physiol. 1938 Aug 15;93(3):301–304. doi: 10.1113/jphysiol.1938.sp003641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DEODHAR S. D. Immunologic production of antiangiotensin. II. Production and detection of antiangiotensin. J Exp Med. 1960 Mar 1;111:429–439. doi: 10.1084/jem.111.3.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DICKINSON C. J., LAWRENCE J. R. A slowly developing pressor response to small concentrations of angiotensin. Its bearing on the pathogenesis of chronic renal hypertension. Lancet. 1963 Jun 22;1(7295):1354–1356. doi: 10.1016/s0140-6736(63)91929-9. [DOI] [PubMed] [Google Scholar]
  6. GOODFRIEND T. L., LEVINE L., FASMAN G. D. ANTIBODIES TO BRADYKININ AND ANGIOTENSIN: A USE OF CARBODIIMIDES IN IMMUNOLOGY. Science. 1964 Jun 12;144(3624):1344–1346. doi: 10.1126/science.144.3624.1344. [DOI] [PubMed] [Google Scholar]
  7. Goodfriend T., Fasman G., Kemp D., Levine L. Immunochemical studies of angiotensin. Immunochemistry. 1966 May;3(3):223–231. doi: 10.1016/0019-2791(66)90186-8. [DOI] [PubMed] [Google Scholar]
  8. HABER E., PAGE L. B., JACOBY G. A. SYNTHESIS OF ANTIGENIC BRANCH-CHAIN COPOLYMERS OF ANGIOTENSIN AND POLY-L-LYSINE. Biochemistry. 1965 Apr;4:693–698. doi: 10.1021/bi00880a013. [DOI] [PubMed] [Google Scholar]
  9. MARX A. J., DEANE H. W., MOWLES T. F., SHEPPARD H. Effects of the chronic administration of synthetic angiotensin in rats. Life Sci. 1963 Jan;1:16–21. doi: 10.1016/0024-3205(63)90032-8. [DOI] [PubMed] [Google Scholar]
  10. WAKERLIN G. E. Antibodies to renin as proof of the pathogenesis of sustained renal hypertension. Circulation. 1958 Apr;17(4 Pt 2):653–657. doi: 10.1161/01.cir.17.4.653. [DOI] [PubMed] [Google Scholar]
  11. WEEKS J. R., JONES J. A. Routine direct measurement of arterial pressure in unanesthetized rats. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:646–648. doi: 10.3181/00379727-104-25937. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES