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. 1969 Sep;37(1):1–9. doi: 10.1111/j.1476-5381.1969.tb09515.x

Histochemical fluorescence studies on noradrenaline accumulation by Uptake2 in the isolated rat heart

D E Clarke, C J Jones, P A Linley
PMCID: PMC1703764  PMID: 5824932

Abstract

1. The distribution of noradrenaline accumulated by Uptake2 (Iversen, 1965) in the isolated perfused rat heart has been observed using histochemical fluorescence microscopy.

2. On the basis of the technique used, noradrenaline seems to be predominantly associated with the cardiac muscle cells, but sympathetic nerves and other cardiac structures also serve as retention sites.

3. Phenoxybenzamine, normetanephrine and perfusion with noradrenaline at 20° C all decreased noradrenaline accumulation.

4. Lowered temperature significantly increased the perfusion pressure and significantly decreased the [14C]-sorbitol space in perfused hearts.

5. The implications of these results are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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