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British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1963 Aug;21(1):67–77. doi: 10.1111/j.1476-5381.1963.tb01502.x

Balanced incomplete block designs in biological assay illustrated by the assay of gastrin using a youden square

D Colquhoun
PMCID: PMC1703851  PMID: 14066152

Abstract

General equations are given for computing the results of any (j+j) dose parallel line biological assay based on an incomplete block design. Only the information from comparisons within blocks is used. The computation is illustrated numerically by means of a (2+2) assay of gastrin devised and performed by Lai (1962), in which only three of the four doses could be given to each animal.

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