Abstract
The adrenaline β-receptor blocking drug, pronethalol, and the sympathomimetic amines, (—)-ephedrine, (—)-amphetamine, dexamphetamine, (—)-Ψ-ephedrine and tyramine, inhibited the sympathomimetic effects of butyrylcholine and tyramine on the guinea-pig isolated atrium. Being reversible and noncompetitive, this antagonism was unspecific and not due to blockade of adrenaline receptors, although pronethalol inhibited the effect of noradrenaline competitively.
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