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. 1980 Jul 19;123(2):105–111.

Mycoplasmas in diseases of humans.

J E Embree, J A Embil
PMCID: PMC1704661  PMID: 6790148

Abstract

The roles of Mycoplasma pneumoniae, M. hominis and Ureaplasma urealyticum in diseases of humans are currently under investigation. M. pneumoniae, which causes primary atypical pneumonia, is a well established pathogen of the respiratory tract. Complications of infection by this organism are also being recognized; they include disorders of the hematopoietic, cardiovascular, central nervous, musculoskeletal, cutaneous and gastrointestinal systems. The roles of the genital mycoplasmas M. hominis and U. urealyticum are controversial but may include infections of the genitourinary tract and in pregnancy as well as diseases of the newborn, such as neonatal pneumonia and meningitis. In this review atypical pneumonia due to M. pneumoniae is described and the role of mycoplasmas in other diseases is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERCOVICI B., PERSKY S., ROZANSKY R., RAZIN S. Mycoplasma (pleuropneumonia-like organisms) in vaginitis. Am J Obstet Gynecol. 1962 Sep 1;84:687–691. doi: 10.1016/0002-9378(62)90165-5. [DOI] [PubMed] [Google Scholar]
  2. Bercovici B., Haas H., Sacks T., Laufer A. Isolation of mycoplasmas from the genital tract of women with reproductive failure, sterility or vaginitis. Isr J Med Sci. 1978 Mar;14(3):347–352. [PubMed] [Google Scholar]
  3. Braun P., Lee Y. H., Klein J. O., Marcy S. M., Klein T. A., Charles D., Levy P., Kass E. H. Birth weight and genital mycoplasmas in pregnancy. N Engl J Med. 1971 Jan 28;284(4):167–171. doi: 10.1056/NEJM197101282840401. [DOI] [PubMed] [Google Scholar]
  4. Brunell P. A., Dische R. M., Walker M. B. Mycoplasma, amnionitis, and respiratory distress syndrome. JAMA. 1969 Mar 17;207(11):2097–2099. [PubMed] [Google Scholar]
  5. Buscho R. O., Saxtan D., Shultz P. S., Finch E., Mufson M. A. Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis. 1978 Apr;137(4):377–383. doi: 10.1093/infdis/137.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cameron D. C., Borthwick R. N., Philp T. The radiographic patterns of acute mycoplasma pneumonitis. Clin Radiol. 1977 Mar;28(2):173–180. doi: 10.1016/s0009-9260(77)80097-4. [DOI] [PubMed] [Google Scholar]
  7. Caspi E., Solomon F., Sompolinsky D. Early abortion and Mycoplasma infection. Isr J Med Sci. 1972 Feb;8(2):122–127. [PubMed] [Google Scholar]
  8. Chester A., Kane J., Garagusi V. Mycoplasma pneumonia with bilateral pleural effusions. Am Rev Respir Dis. 1975 Sep;112(3):451–456. doi: 10.1164/arrd.1975.112.3.451. [DOI] [PubMed] [Google Scholar]
  9. Chusid M. J., Lachman B. S., Lazerson J. Severe Mycoplasma pneumonia and vesicular eruption in SC hemoglobinopathy. J Pediatr. 1978 Sep;93(3):449–451. doi: 10.1016/s0022-3476(78)81156-1. [DOI] [PubMed] [Google Scholar]
  10. De Vos M., Van Nimmen L., Baele G. Disseminated intravascular coagulation during a fatal Mycoplasma pneumoniae infection. Acta Haematol. 1974;52(2):120–125. doi: 10.1159/000208229. [DOI] [PubMed] [Google Scholar]
  11. Dorff B., Lind K. Two fatal cases of meningoencephalitis associated with Mycoplasma pneumoniae infection. Scand J Infect Dis. 1976;8(1):49–51. [PubMed] [Google Scholar]
  12. Fernald G. W., Collier A. M., Clyde W. A., Jr Respiratory infections due to Mycoplasma pneumoniae in infants and children. Pediatrics. 1975 Mar;55(3):327–335. [PubMed] [Google Scholar]
  13. Finland M., Peterson O. L., Allen H. E., Samper B. A., Barnes M. W., Stone M. B. COLD AGGLUTININS. I. OCCURRENCE OF COLD ISOHEMAGGLUTININS IN VARIOUS CONDITIONS. J Clin Invest. 1945 Jul;24(4):451–457. doi: 10.1172/JCI101623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Foy H. M., Kenny G. E., McMahan R., Mansy A. M., Grayston J. T. Mycoplasma pneumoniae pneumonia in an urban area. Five years of surveillance. JAMA. 1970 Nov 30;214(9):1666–1672. [PubMed] [Google Scholar]
  15. Foy H. M., Ochs H., Davis S. D., Kenny G. E., Luce R. R. Mycoplasma pneumoniae infections in patients with immunodeficiency syndromes: report of four cases. J Infect Dis. 1973 Apr;127(4):388–393. doi: 10.1093/infdis/127.4.388. [DOI] [PubMed] [Google Scholar]
  16. Freberg J., Gnarpe H. Mycoplasma and human reproductive failure. 3. Pregnancies in "infertile" couples treated with doxycycline for T-0mycoplasmas. Am J Obstet Gynecol. 1973 May 1;116(1):23–26. [PubMed] [Google Scholar]
  17. Freeman R., McMahon M. J. Acute pancreatitis and serological evidence of infection with Mycoplasma pneumoniae. Gut. 1978 May;19(5):367–370. doi: 10.1136/gut.19.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Friedlander A. M., Braude A. I. Production of bladder stones by human T mycoplasmas. Nature. 1974 Jan 4;247(5435):67–69. doi: 10.1038/247067b0. [DOI] [PubMed] [Google Scholar]
  19. Gewitz M., Dinwiddie R., Rees L., Volikas O., Yuille T., O'Connell B., Marshall W. C. Mycoplasma hominis. A cause of neonatal meningitis. Arch Dis Child. 1979 Mar;54(3):231–233. doi: 10.1136/adc.54.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Gnarpe H., Friberg J. Mycoplasma and human reproductive failure. I. The occurrence of different Mycoplasmas in couples with reproductive failure. Am J Obstet Gynecol. 1972 Nov 15;114(6):727–731. [PubMed] [Google Scholar]
  21. Halal F., Brochu P., Delage G., Lamarre A., Rivard G. Severe disseminated lung disease and bronchiectasis probably due to Mycoplasma pneumoniae. Can Med Assoc J. 1977 Nov 5;117(9):1055–1056. [PMC free article] [PubMed] [Google Scholar]
  22. Harrison R. F., de Louvois J., Blades M., Hurley R. Doxycycline treatment and human infertility. Lancet. 1975 Mar 15;1(7907):605–607. doi: 10.1016/s0140-6736(75)91885-1. [DOI] [PubMed] [Google Scholar]
  23. Harwick H. J., Purcell R. H., Iuppa J. B., Fekety F. R., Jr Mycoplasma hominis and abortion. J Infect Dis. 1970 Mar;121(3):260–268. doi: 10.1093/infdis/121.3.260. [DOI] [PubMed] [Google Scholar]
  24. Hernandez L. A., Urquhart G. E., Dick W. C. Mycoplasma pneumoniae infection and arthritis in man. Br Med J. 1977 Jul 2;2(6078):14–16. doi: 10.1136/bmj.2.6078.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Huhti E., Mokka T., Nikoskelainen J., Halonen P. Association of viral and mycoplasma infections with exacerbations of asthma. Ann Allergy. 1974 Sep;33(3):145–149. [PubMed] [Google Scholar]
  26. Ionno J. A., Westfall R. E. Mycoplasma pneumoniae pneumonia: clinical course and complications. Mil Med. 1970 Jun;135(6):459–463. [PubMed] [Google Scholar]
  27. Jachuck S. J., Gardner-Thorpe C., Clark F., Foster J. B. A brainstem syndrome associated with Mycoplasma pneumoniae infection. A report of two cases. Postgrad Med J. 1975 Jul;51(597):475–477. doi: 10.1136/pgmj.51.597.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Klein J. O., Buckland D., Finland M. Colonization of newborn infants by mycoplasmas. N Engl J Med. 1969 May 8;280(19):1025–1030. doi: 10.1056/NEJM196905082801901. [DOI] [PubMed] [Google Scholar]
  29. Lamey J. R., Foy H. M., Kenny G. E. Infection with Mycoplasma hominis and T-strains in the female genital tract. Obstet Gynecol. 1974 Nov;44(5):703–708. [PubMed] [Google Scholar]
  30. Lee Y. H., McCormack W. M. Clinical implication of the genital mycoplasmas in obstetrics and gynecology. J Reprod Med. 1974 Oct;13(4):123–127. [PubMed] [Google Scholar]
  31. Lee Y. H., Tarr P. I., Schumacher J. R., Rosner B., Alpert S., McCormack W. M. Reevaluation of the role of T-mycoplasmas in nongonococcal urethritis. J Am Vener Dis Assoc. 1976 Sep;3(1):25–28. [PubMed] [Google Scholar]
  32. Levine D. P., Lerner A. M. The clinical spectrum of Mycoplasma pneumoniae infections. Med Clin North Am. 1978 Sep;62(5):961–978. doi: 10.1016/s0025-7125(16)31749-7. [DOI] [PubMed] [Google Scholar]
  33. Lewes D., Rainford D. J., Lane W. F. Symptomless myocarditis and myalgia in viral and Mycoplasma pneumoniae infections. Br Heart J. 1974 Sep;36(9):924–932. doi: 10.1136/hrt.36.9.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Maisel J. C., Babbitt L. H., John T. J. Fatal Mycoplasma pneumoniae infection with isolation of organisms from lung. JAMA. 1967 Oct 23;202(4):287–290. [PubMed] [Google Scholar]
  35. Maresh H., Klimek J. J., Quintiliani R. Myocardial dysfunction and hemolytic anemia in a patient with Mycoplasma pneumoniae infection. Chest. 1977 Mar;71(3):410–413. doi: 10.1378/chest.71.3.410. [DOI] [PubMed] [Google Scholar]
  36. Matthews C. D., Elmslie R. G., Clapp K. H., Svigos J. M. The frequency of genital mycoplasma infection in human fertility. Fertil Steril. 1975 Oct;26(10):988–990. doi: 10.1016/s0015-0282(16)41412-3. [DOI] [PubMed] [Google Scholar]
  37. McCormack W. M., Almeida P. C., Bailey P. E., Grady E. M., Lee Y. H. Sexual activity and vaginal colonization with genital mycoplasmas. JAMA. 1972 Sep 18;221(12):1375–1377. [PubMed] [Google Scholar]
  38. McCormack W. M., Braun P., Lee Y. H., Klein J. O., Kass E. H. The genital mycoplasmas. N Engl J Med. 1973 Jan 11;288(2):78–89. doi: 10.1056/NEJM197301112880206. [DOI] [PubMed] [Google Scholar]
  39. McCormack W. M., Lee Y. H., Zinner S. H. Sexual experience and urethral colonization with genital mycoplasmas. A study in normal men. Ann Intern Med. 1973 May;78(5):696–698. doi: 10.7326/0003-4819-78-5-696. [DOI] [PubMed] [Google Scholar]
  40. Murray H. W., Masur H., Senterfit L. B., Roberts R. B. The protean manifestations of Mycoplasma pneumoniae infection in adults. Am J Med. 1975 Feb;58(2):229–242. doi: 10.1016/0002-9343(75)90574-4. [DOI] [PubMed] [Google Scholar]
  41. Nilsson I. M., Rausing A., Denneberg T., Christensson P. Intravascular coagulation and acute renal failure in a child with mycoplasma infection. Acta Med Scand. 1971 May;189(5):359–365. doi: 10.1111/j.0954-6820.1971.tb04390.x. [DOI] [PubMed] [Google Scholar]
  42. Noah N. D. Epidemiology of Mycoplasma pneumoniae infection in the United Kingdom: an analysis of reports to the Public Health Laboratory Service of England and Wales. Infection. 1976;4(1 Suppl):25–28. doi: 10.1007/BF01638418. [DOI] [PubMed] [Google Scholar]
  43. Oldenburger D., Carson J. P., Gundlach W. J., Ghaly F. I., Wright W. H. Legionnaires' disease. Association with mycoplasma pneumonia and disseminated intravascular coagulation. JAMA. 1979 Mar 23;241(12):1269–1270. doi: 10.1001/jama.241.12.1269. [DOI] [PubMed] [Google Scholar]
  44. Riski H., Alanko K. Mycoplasma and influenza pneumonia in a series of 214 adults. Scand J Respir Dis Suppl. 1974;89:235–245. [PubMed] [Google Scholar]
  45. Sands M. J., Jr, Satz J. E., Turner W. E., Jr, Soloff L. A. Pericarditis and perimyocarditis associated with active Mycoplasma pneumoniae infection. Ann Intern Med. 1977 May;86(5):544–548. doi: 10.7326/0003-4819-86-5-544. [DOI] [PubMed] [Google Scholar]
  46. Schoub B. D., Jacobs Y. R., Hylén E., Freedman R. The role of Mycoplasma in human infertility. S Afr Med J. 1976 Mar 13;50(11):445–447. [PubMed] [Google Scholar]
  47. Siber G. R., Alpert S., Smith A. L., Lin J. S., McCormack W. M. Neonatal central nervous system infection due to Mycoplasma hominis. J Pediatr. 1977 Apr;90(4):625–627. doi: 10.1016/s0022-3476(77)80385-5. [DOI] [PubMed] [Google Scholar]
  48. Simmons B. P., Aber R. C. Mycoplasma pneumoniae pneumonia. Symptoms mimicking pulmonary embolism with infarction. JAMA. 1979 Mar 23;241(12):1268–1269. doi: 10.1001/jama.241.12.1268. [DOI] [PubMed] [Google Scholar]
  49. Smith C. B., Overall J. C., Jr Clinical and epidemiologic clues to the diagnosis of respiratory infections. Radiol Clin North Am. 1973 Aug;11(2):261–278. [PubMed] [Google Scholar]
  50. Sompolinsky D., Solomon F., Elkina L., Weinraub Z., Bukovsky I., Caspi E. Infections with mycoplasma and bacteria in induced midtrimester abortion and fetal loss. Am J Obstet Gynecol. 1975 Mar 1;121(5):610–616. doi: 10.1016/0002-9378(75)90460-3. [DOI] [PubMed] [Google Scholar]
  51. Sontheimer R. D., Garibaldi R. A., Krueger G. G. Stevens-Johnson syndrome associated with Mycoplasma pneumoniae infections. Arch Dermatol. 1978 Feb;114(2):241–244. [PubMed] [Google Scholar]
  52. Stokes D., Sigler A., Khouri N. F., Talamo R. C. Unilateral hyperlucent lung (Swyer-James syndrome) after severe Mycoplasma pneumoniae infection. Am Rev Respir Dis. 1978 Jan;117(1):145–152. doi: 10.1164/arrd.1978.117.1.145. [DOI] [PubMed] [Google Scholar]
  53. Tafari N., Ross S., Naeye R. L., Judge D. M., Marboe C. Mycoplasma T strains and perinatal death. Lancet. 1976 Jan 17;1(7951):108–109. doi: 10.1016/s0140-6736(76)93152-4. [DOI] [PubMed] [Google Scholar]
  54. Taylor-Robinson D., Csonka G. W., Prentice M. J. Chlamydial and ureaplasma-associated urethritis. Lancet. 1977 Apr 23;1(8017):903–903. doi: 10.1016/s0140-6736(77)91222-3. [DOI] [PubMed] [Google Scholar]
  55. Taylor-Robinson D. The importance of mycoplasmas in respiratory infections. Dev Biol Stand. 1975;28:86–100. [PubMed] [Google Scholar]
  56. Thomas M., Jones M., Ray S., Andrews B. Letter: Mycoplasma pneumoiae in a tubo-ovarian abscess. Lancet. 1975 Oct 18;2(7938):774–775. doi: 10.1016/s0140-6736(75)90765-5. [DOI] [PubMed] [Google Scholar]
  57. Verinder D. G. Septic arthritis due to mycoplasma hominis. A case report and review of the literature. J Bone Joint Surg Br. 1978 May;60-B(2):224–224. doi: 10.1302/0301-620X.60B2.659469. [DOI] [PubMed] [Google Scholar]
  58. Warren P., Fischbein C., Mascoli N., Rudolph J., Hodder D. H. Poliomyelitis-like syndrome caused by Mcyoplasma pneumoniae. J Pediatr. 1978 Sep;93(3):451–452. doi: 10.1016/s0022-3476(78)81157-3. [DOI] [PubMed] [Google Scholar]
  59. Wealthall S. R. Mycoplasma meningitis in infants with spina bifida. Dev Med Child Neurol Suppl. 1975;(35):117–122. doi: 10.1111/j.1469-8749.1975.tb03590.x. [DOI] [PubMed] [Google Scholar]
  60. Webster A. D., Taylor-Robinson D., Furr P. M., Asherson G. L. Mycoplasmal (ureaplasma) septic arthritis in hypogammaglobulinaemia. Br Med J. 1978 Feb 25;1(6111):478–479. doi: 10.1136/bmj.1.6111.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Weinstein M. P., Hall C. B. Mycoplasma pneumoniae infection associated with migratory polyarthritis. Am J Dis Child. 1974 Jan;127(1):125–126. doi: 10.1001/archpedi.1974.02110200127020. [DOI] [PubMed] [Google Scholar]

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