Skip to main content
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1980 Oct 18;123(8):750–753.

Treatment of acute renal failure due to myeloma kidney.

R A Bear, E H Cole, A Lang, M Johnson
PMCID: PMC1704861  PMID: 7004618

Abstract

Severe renal insufficiency is considered to indicate a poor prognosis in patients with multiple myeloma, their reported median survival being approximately 2 months. In five consecutive patients with severe renal failure secondary to acute myeloma kidney early aggressive therapy, including chemotherapy and peritoneal dialysis, led to a significant improvement in the renal function of four; the fifth patient received a cadaveric renal transplant after 1 year of peritoneal dialysis. After a median follow-up period of 12 months all the patients were alive and had improved renal function. This experience contrasts with that previously reported and suggests that aggressive management may improve the survival of patients with acute renal failure due to myeloma kidney.

Full text

PDF
753

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown W. W., Hebert L. A., Piering W. F., Pisciotta A. V., Lemann J., Jr, Garancis J. C. Reversal of chronic end-stage renal failure due to myeloma kidney. Ann Intern Med. 1979 May;90(5):793–794. doi: 10.7326/0003-4819-90-5-793. [DOI] [PubMed] [Google Scholar]
  2. Bryan C. W., Healy J. K. Acute renal failure in multiple myeloma. Am J Med. 1968 Jan;44(1):128–133. doi: 10.1016/0002-9343(68)90244-1. [DOI] [PubMed] [Google Scholar]
  3. Cohen H. J., Rundles R. W. Managing the complications of plasma cell myeloma. Arch Intern Med. 1975 Jan;135(1):177–184. [PubMed] [Google Scholar]
  4. Dawson A. A., Ogston D. Factors influencing the prognosis in myelomatosis. Postgrad Med J. 1971 Oct;47(552):635–638. doi: 10.1136/pgmj.47.552.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Defronzo R. A., Humphrey R. L., Wright J. R., Cooke C. R. Acute renal failure in multiple myeloma. Medicine (Baltimore) 1975 May;54(3):209–223. doi: 10.1097/00005792-197505000-00003. [DOI] [PubMed] [Google Scholar]
  6. Humphrey R. L., Wright J. R., Zachary J. B., Sterioff S., DeFronzo R. A. Renal transplantation in multiple myeloma. A case report. Ann Intern Med. 1975 Nov;83(5):651–653. doi: 10.7326/0003-4819-83-5-651. [DOI] [PubMed] [Google Scholar]
  7. Johnson W. J., Kyle R. A., Dahlberg P. J. Dialysis in the treatment of multiple myeloma. Mayo Clin Proc. 1980 Feb;55(2):65–72. [PubMed] [Google Scholar]
  8. Kyle R. A. Multiple myeloma: review of 869 cases. Mayo Clin Proc. 1975 Jan;50(1):29–40. [PubMed] [Google Scholar]
  9. Misiani R., Remuzzi G., Bertani T., Licini R., Levoni P., Crippa A., Mecca G. Plasmapheresis in the treatment of acute renal failure in multiple myeloma. Am J Med. 1979 Apr;66(4):684–688. doi: 10.1016/0002-9343(79)91185-9. [DOI] [PubMed] [Google Scholar]
  10. PUTNAM F. W. Plasma-cell myeloma and macroglobulinemia. I. Physicochemical, immunochemical and isotopic turnover studies of the abnormal serum and urinary proteins. N Engl J Med. 1959 Oct 29;261:902–908. doi: 10.1056/NEJM195910292611806. [DOI] [PubMed] [Google Scholar]
  11. Preuss H. G., Hammack W. J., Murdaugh H. V. The effect of Bence Jones protein on the in vitro function of rabbit renal cortex. Nephron. 1968;5(3):210–216. doi: 10.1159/000179631. [DOI] [PubMed] [Google Scholar]
  12. Smithline N., Kassirer J. P., Cohen J. J. Light-chain nephropathy. Renal tubular dysfunction associated with light-chain proteinuria. N Engl J Med. 1976 Jan 8;294(2):71–74. doi: 10.1056/NEJM197601082940202. [DOI] [PubMed] [Google Scholar]
  13. Stone M. J., Frendel E. P. The clinical spectrum of light chain myeloma. A study of 35 patients with special reference to the occurrence of amyloidosis. Am J Med. 1975 May;58(5):601–619. doi: 10.1016/0002-9343(75)90496-9. [DOI] [PubMed] [Google Scholar]
  14. Vaziri N. D., Goldman R., Schultze R. G., Lee D. B., Rosen S. M. Maintenance hemodialysis in myeloma kidney disease. West J Med. 1977 Feb;126(2):91–94. [PMC free article] [PubMed] [Google Scholar]
  15. Wochner R. D., Strober W., Waldmann T. A. The role of the kidney in the catabolism of Bence Jones proteins and immunoglobulin fragments. J Exp Med. 1967 Aug 1;126(2):207–221. doi: 10.1084/jem.126.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Yium J., Martinez-Maldonado M., Eknoyan G., Suki W. N. Peritoneal dialysis in the treatment of renal failure in multiple myeloma. South Med J. 1971 Nov;64(11):1403–1405. doi: 10.1097/00007611-197111000-00025. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES