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. 1981 Feb 1;124(3):267-77, 297.

Observations on the relation between alcohol absorption and the rate of gastric emptying.

S Holt
PMCID: PMC1705129  PMID: 7459787

Abstract

Alcohol (ethanol) is absorbed slowly from the stomach and rapidly from the small intestine, and the rate of its absorption depends on the rate of gastric emptying. When gastric emptying is fast, the absorption of alcohol is fast. When gastric emptying is slow the absorption of alcohol is delayed and peak blood alcohol concentrations are reduced. Alterations of the gastric emptying rate, which may have a physiologic, pharmacologic or pathologic cause, markedly influence the rate of alcohol absorption. The gastric emptying rate makes an important contribution to inter- and intraindividual variations in the rate of alcohol absorption and therefore the timing and magnitude of the acute intoxicating effect of an oral dose of alcohol.

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Selected References

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  1. BAYLY R. C., McCALLUM N. E. Some aspects of alcohol in body fluids. II. The change in blood alcohol concentration following alcohol consumption. Med J Aust. 1959 Aug 8;46(2):173–176. [PubMed] [Google Scholar]
  2. BERNARD A., DELATTRE A., LAMELIN P. LE M'ECANISME D'ACTION DE L'ALCOOL SUR LA MUQUEUSE GASTRIQUE: SA PROPRI'ET'E HYGROSCOPIQUE ET D'ESHYDRATANTE. Acta Gastroenterol Belg. 1964 Feb;27:129–147. [PubMed] [Google Scholar]
  3. BERRIDGE F. R., PRIOR K. M. Studies of undernutrition, Wuppertal 1946-9. XXV. Radiological observations on the bones. Spec Rep Ser Med Res Counc (G B) 1951;275:289–295. [PubMed] [Google Scholar]
  4. BOBO C. G., DELGA J., JAULMES C. Métabolisme de l'alcool chez les animaux soumis a l'hibernation artificielle. C R Seances Soc Biol Fil. 1956 Nov 18;150(6):1094–1097. [PubMed] [Google Scholar]
  5. Barboriak J. J., Meade R. C. Effect of alcohol on gastric emptying in man. Am J Clin Nutr. 1970 Sep;23(9):1151–1153. doi: 10.1093/ajcn/23.9.1151. [DOI] [PubMed] [Google Scholar]
  6. Barboriak J. J., Meade R. C. Impairment of gastrointestinal processing of fat and protein by ethanol in rats. J Nutr. 1969 Jul;98(3):373–378. doi: 10.1093/jn/98.3.373. [DOI] [PubMed] [Google Scholar]
  7. Bateman D. N., Kahn C., Mashiter K., Davies D. S. Pharmacokinetic and concentration-effect studies with intravenous metoclopramide. Br J Clin Pharmacol. 1978 Nov;6(5):401–407. doi: 10.1111/j.1365-2125.1978.tb04604.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Burn-Murdoch R. A., Fisher M. A., Hunt J. N. The slowing of gastric emptying by proteins in test meals. J Physiol. 1978 Jan;274:477–485. doi: 10.1113/jphysiol.1978.sp012161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Campbell I. W., Heading R. C., Tothill P., Buist T. A., Ewing D. J., Clarke B. F. Gastric emptying in diabetic autonomic neuropathy. Gut. 1977 Jun;18(6):462–467. doi: 10.1136/gut.18.6.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Colmer M. R., Owen G. M., Shields R. Pattern of gastric emptying after vagotomy and pyloroplasty. Br Med J. 1973 May 26;2(5864):448–450. doi: 10.1136/bmj.2.5864.448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cooke A. R., Birchall A. Absorption of ethanol from the stomach. Gastroenterology. 1969 Sep;57(3):269–272. [PubMed] [Google Scholar]
  12. Cooke A. R., Clark E. D. Effect of first part of duodenum on gastric emptying in dogs: response to acid, fat, glucose, and neural blockade. Gastroenterology. 1976 Apr;70(4):550–555. [PubMed] [Google Scholar]
  13. Cooke A. R. Control of gastric emptying and motility. Gastroenterology. 1975 Apr;68(4 Pt 1):804–816. [PubMed] [Google Scholar]
  14. Cooke A. R. Duodenal acidification: Role of first part of duodenum in gastric emptying and secretion in dogs. Gastroenterology. 1974 Jul;67(1):85–92. [PubMed] [Google Scholar]
  15. Cooke A. R. Ethanol and gastric function. Gastroenterology. 1972 Mar;62(3):501–502. [PubMed] [Google Scholar]
  16. Cooke A. R., Moulang J. Control of gastric emptying by amino acids. Gastroenterology. 1972 Apr;62(4):528–532. [PubMed] [Google Scholar]
  17. Cooke A. R. The stimultaneous emptying and absorption of ethanol from the human stomach. Am J Dig Dis. 1970 May;15(5):449–454. doi: 10.1007/BF02283874. [DOI] [PubMed] [Google Scholar]
  18. Cooperman A. M., Cook S. A. Gastric emptying--physiology and measurements. Surg Clin North Am. 1976 Dec;56(6):1277–1287. doi: 10.1016/s0039-6109(16)41083-2. [DOI] [PubMed] [Google Scholar]
  19. Cotton P. B., Walker G. Ethanol absorption after gastric operations, and in the coeliac syndrome. Postgrad Med J. 1973 Jan;49(567):27–28. doi: 10.1136/pgmj.49.567.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Davenport H. W. Ethanol damage to canine oxyntic glandular mucosa. Proc Soc Exp Biol Med. 1967 Dec;126(3):657–662. doi: 10.3181/00379727-126-32532. [DOI] [PubMed] [Google Scholar]
  21. ELMSLIE R. G., DAVIS R. A., WHITE T. T. ABSORPTION OF ALCOHOL AFTER GASTRECTOMY. Surg Gynecol Obstet. 1964 Dec;119:1256–1258. [PubMed] [Google Scholar]
  22. Faxén A., Kewenter J. The effect of parietal cell vagotomy and selective vagotomy with pyloroplasty on gastric emptying of a liquid meal. A prospective randomized study. Scand J Gastroenterol. 1978;13(5):545–550. doi: 10.3109/00365527809181762. [DOI] [PubMed] [Google Scholar]
  23. Fleming J. A., Haynes S., LQuesne L. P. The effect of vagotomy and a drainage procedure on alcohol tolerance. Br J Surg. 1971 Feb;58(2):92–96. doi: 10.1002/bjs.1800580203. [DOI] [PubMed] [Google Scholar]
  24. Fox J. E., Bourdages R., Beck I. T. Effect of ethanol on glucose and water absorption in hamster jejunum in vivo. Methodological problems: anesthesia, nonabsorbable markers, and osmotic effect. Am J Dig Dis. 1978 Mar;23(3):193–200. doi: 10.1007/BF01072317. [DOI] [PubMed] [Google Scholar]
  25. GILLESPIE R. J., LUCAS C. C. Effect of single intoxicating doses of ethanol on the gastric and intestinal mucosa of rats. Can J Biochem Physiol. 1961 Feb;39:237–241. doi: 10.1139/o61-021. [DOI] [PubMed] [Google Scholar]
  26. GRUNER O. Untersuchungen über die Beeinflussbarkeit der Alkoholresorption durch psychische Faktoren. Dtsch Z Gesamte Gerichtl Med. 1956;45(5):401–413. [PubMed] [Google Scholar]
  27. Gibbons D. O., Lant A. F. Effects of intravenous and oral propantheline and metoclopramide on ethanol absorption. Clin Pharmacol Ther. 1975 May;17(5):578–584. doi: 10.1002/cpt1975175578. [DOI] [PubMed] [Google Scholar]
  28. Grimes D. S., Goddard J. Effect of cigarette smoking on gastric emptying. Br Med J. 1978 Aug 12;2(6135):460–461. doi: 10.1136/bmj.2.6135.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. HARGER R. N., FORNEY R. B., BARNES H. B. Estimation of the level of blood alcohol from analysis of breath. J Lab Clin Med. 1950 Aug;36(2):306–318. [PubMed] [Google Scholar]
  30. HOGBEN C. A., SCHANKER L. S., TOCCO D. J., BRODIE B. B. Absorption of drugs from the stomach. II. The human. J Pharmacol Exp Ther. 1957 Aug;120(4):540–545. [PubMed] [Google Scholar]
  31. HUNT J. N. GASTRIC EMPTYING IN RELATION TO DRUG ABSORPTION. Am J Dig Dis. 1963 Nov;8:885–894. doi: 10.1007/BF02232082. [DOI] [PubMed] [Google Scholar]
  32. HUNT J. N., SPURRELL W. R. The pattern of emptying of the human stomach. J Physiol. 1951 Apr;113(2-3):157–168. doi: 10.1113/jphysiol.1951.sp004562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Hall R. C., Brown D., Carter R., Kendall M. J. The effect of desmethylimipramine on the absorption of alcohol and paracetamol. Postgrad Med J. 1976 Mar;52(605):139–142. doi: 10.1136/pgmj.52.605.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Hawkins R. D., Kalant H. The metabolism of ethanol and its metabolic effects. Pharmacol Rev. 1972 Mar;24(1):67–157. [PubMed] [Google Scholar]
  35. Heading R. C., Nimmo J., Prescott L. F., Tothill P. The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol. 1973 Feb;47(2):415–421. doi: 10.1111/j.1476-5381.1973.tb08339.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Heading R. C., Tothill P., Laidlaw A. J., Shearman D. J. An evaluation of indium DTPA chelate in the measurement of gastric emptying by scintiscanning. Gut. 1971 Aug;12(8):611–615. doi: 10.1136/gut.12.8.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Hillbom M. E. Thyroid state and voluntary alcohol consumption of albino rats. Acta Pharmacol Toxicol (Copenh) 1971;29(1):95–105. doi: 10.1111/j.1600-0773.1971.tb00587.x. [DOI] [PubMed] [Google Scholar]
  38. Hillbom M. E., Wallgren H. Role of gastric emptying on ethanol poisoning in rats. Med Biol. 1978 Feb;56(1):37–41. [PubMed] [Google Scholar]
  39. Holt S., Heading R. C., Carter D. C., Prescott L. F., Tothill P. Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet. 1979 Mar 24;1(8117):636–639. doi: 10.1016/s0140-6736(79)91079-1. [DOI] [PubMed] [Google Scholar]
  40. Holt S., Stewart M. J., Adam R. D., Heading R. C. Alcohol absorption, gastric emptying and a breathalyser. Br J Clin Pharmacol. 1980 Feb;9(2):205–208. doi: 10.1111/j.1365-2125.1980.tb05834.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Hunt J. N., Cash R., Newland P. Energy density of food, gastric emptying, and obesity. Lancet. 1975 Nov 8;2(7941):905–906. doi: 10.1016/s0140-6736(75)92133-9. [DOI] [PubMed] [Google Scholar]
  42. Hunt J. N., Pathak J. D. The osmotic effects of some simple molecules and ions on gastric emptying. J Physiol. 1960 Dec;154(2):254–269. doi: 10.1113/jphysiol.1960.sp006577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Hurwitz A. Antacid therapy and drug kinetics. Clin Pharmacokinet. 1977 Jul-Aug;2(4):269–280. doi: 10.2165/00003088-197702040-00003. [DOI] [PubMed] [Google Scholar]
  44. JACOBSEN E. The metabolism of ethyl alcohol. Pharmacol Rev. 1952 Jun;4(2):107–135. [PubMed] [Google Scholar]
  45. JOKIPII S. G. Experimental studies on blood alcohol in healthy subjects and in some diseases. Ann Med Exp Biol Fenn. 1951;29(2):1–99. [PubMed] [Google Scholar]
  46. Janus E. D., Sharman J. R. Milk and blood alcohol. N Z Med J. 1972 Jun;75(481):339–342. [PubMed] [Google Scholar]
  47. Jones A. W. Variability of the blood:breath alcohol ratio in vivo. J Stud Alcohol. 1978 Nov;39(11):1931–1939. doi: 10.15288/jsa.1978.39.1931. [DOI] [PubMed] [Google Scholar]
  48. Jones B. M., Vega A. Cognitive performance measured on the ascending and descending limb of the blood alcohol curve. Psychopharmacologia. 1972;23(2):99–114. doi: 10.1007/BF00401185. [DOI] [PubMed] [Google Scholar]
  49. Kaufman S. E., Kaye M. D. Effect of ethanol upon gastric emptying. Gut. 1979 Aug;20(8):688–692. doi: 10.1136/gut.20.8.688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Kelly K. A., Code C. F. Effect of transthoracic vagotomy on canine gastric electrical activity. Gastroenterology. 1969 Jul;57(1):51–58. [PubMed] [Google Scholar]
  51. LEIKOLA A. Influence of stress on alcohol intoxication in rats. Q J Stud Alcohol. 1962 Sep;23:369–375. [PubMed] [Google Scholar]
  52. LISH P. M. Some pharmacologic effects of dioctyl sodium sulfosuccinate on the gastrointestinal tract of the rat. Gastroenterology. 1961 Dec;41:580–584. [PubMed] [Google Scholar]
  53. Lang A. R., Goeckner D. J., Adesso V. J., Marlatt G. A. Effects of alcohol on aggression in male social drinkers. J Abnorm Psychol. 1975 Oct;84(5):508–518. doi: 10.1037/h0077055. [DOI] [PubMed] [Google Scholar]
  54. Levine R. R. Factors affecting gastrointestinal absorption of drugs. Am J Dig Dis. 1970 Feb;15(2):171–188. doi: 10.1007/BF02235648. [DOI] [PubMed] [Google Scholar]
  55. Lin Y., Weidler D. J., Garg D. C., Wagner J. G. Effects of solid food on blood levels of alcohol in man. Res Commun Chem Pathol Pharmacol. 1976 Apr;13(4):713–722. [PubMed] [Google Scholar]
  56. Mattila M. J., Linnoila M., Seppälä T., Koskinen R. Effect of aluminium hydroxide and glycopyrrhonium on the absorption of ethambutol and alcohol in man. Br J Clin Pharmacol. 1978 Feb;5(2):161–166. doi: 10.1111/j.1365-2125.1978.tb01618.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Mendelson J. H., Mello N. K. Medical progress. Biologic concomitants of alcoholism. N Engl J Med. 1979 Oct 25;301(17):912–921. doi: 10.1056/NEJM197910253011704. [DOI] [PubMed] [Google Scholar]
  58. Moodie A. F., Royston C. M., Spencer J. Alcohol tolerance after proximal gastric vagotomy. Gut. 1975 Dec;16(12):966–967. doi: 10.1136/gut.16.12.966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Nimmo W. S. Drugs, diseases and altered gastric emptying. Clin Pharmacokinet. 1976;1(3):189–203. doi: 10.2165/00003088-197601030-00002. [DOI] [PubMed] [Google Scholar]
  60. Prescott L. F. Gastrointestinal absorption of drugs. Med Clin North Am. 1974 Sep;58(5):907–916. doi: 10.1016/s0025-7125(16)32088-0. [DOI] [PubMed] [Google Scholar]
  61. Pryor W. J. Social drinking and blood alcohol levels. N Z Med J. 1966 Oct;65(410):689–690. [PubMed] [Google Scholar]
  62. Puurunen J., Karppanen H. Effects of ethanol on gastric acid secretion and gastric mucosal cyclic AMP in the rat. Life Sci. 1975 May 15;16(10):1513–1520. doi: 10.1016/0024-3205(75)90068-5. [DOI] [PubMed] [Google Scholar]
  63. Rimer D. G. Gastric retention without mechanical obstruction. A review. Arch Intern Med. 1966 Feb;117(2):287–299. [PubMed] [Google Scholar]
  64. Ryback R. S. The continuum and specificity of the effects of alcohol on memory. A review. Q J Stud Alcohol. 1971 Dec;32(4):995–1016. [PubMed] [Google Scholar]
  65. SUTHERLAND V. C., BURBRIDGE T. N., ADAMS J. E., SIMON A. Cerebral metabolism in problem drinkers under the influence of alcohol and chlorpromazine hydrochloride. J Appl Physiol. 1960 Mar;15:189–196. doi: 10.1152/jappl.1960.15.2.189. [DOI] [PubMed] [Google Scholar]
  66. Sedman A. J., Wilkinson P. K., Sakmar E., Weidler D. J., Wagner J. G. Food effects on absorption and metabolism of alcohol. J Stud Alcohol. 1976 Sep;37(9):1197–1214. doi: 10.15288/jsa.1976.37.1197. [DOI] [PubMed] [Google Scholar]
  67. Sheiner H. J. Gastric emptying tests in man. Gut. 1975 Mar;16(3):235–247. doi: 10.1136/gut.16.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Siegers C. P., Strubelt O., Back G. Inhibition by caffeine of ethanol absorption in rats. Eur J Pharmacol. 1972 Nov;20(2):181–187. doi: 10.1016/0014-2999(72)90147-1. [DOI] [PubMed] [Google Scholar]
  69. Victor Y. H. Effect of body position on gastric emptying in the neonate. Arch Dis Child. 1975 Jul;50(7):500–504. doi: 10.1136/adc.50.7.500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Wagner J. G., Patel J. A. Variations in absorption and elimination rates of ethyl alcohol in a single subject. Res Commun Chem Pathol Pharmacol. 1972 Jul;4(1):61–76. [PubMed] [Google Scholar]
  71. Wilkinson P. K., Sedman A. J., Sakmar E., Lin Y. J., Wagner J. G. Fasting and nonfasting blood ethanol concentrations following repeated oral administration of ethanol to one adult male subject. J Pharmacokinet Biopharm. 1977 Feb;5(1):41–52. doi: 10.1007/BF01064808. [DOI] [PubMed] [Google Scholar]
  72. Wilson G. T., Lawson D. M. Expectancies, alcohol, and sexual arousal in male social drinkers. J Abnorm Psychol. 1976 Dec;85(6):587–594. doi: 10.1037//0021-843x.85.6.587. [DOI] [PubMed] [Google Scholar]
  73. Winne D., Remischovsky J. Der Einfluss der Durchblutung auf die Resorption von Harnstoff, Methanol und Athanol aus dem Jejunum der Ratte. Naunyn Schmiedebergs Arch Pharmakol. 1971;268(4):392–416. [PubMed] [Google Scholar]
  74. Wright B. M., Jones T. P., Jones A. W. Breath alcohol analysis and the blood: breath ratio. Med Sci Law. 1975 Jul;15(3):205–210. doi: 10.1177/002580247501500309. [DOI] [PubMed] [Google Scholar]
  75. Young J. R. Blood alcohol concentration and reaction time. Q J Stud Alcohol. 1970 Dec;31(4):823–831. [PubMed] [Google Scholar]

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