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. 1970 Mar;6(3):407–411.

Studies of the third component of complement in synovial fluid from arthritic patients. I. Immunochemical quantitation and relation to total complement

B Lundh, H Hedberg, Anna-Brita Laurell
PMCID: PMC1712699  PMID: 5442523

Abstract

In a study of forty-one patients, most of whom had longstanding rheumatoid arthritis, a comparison was made in serum and synovial fluid between total complement activity (CH50) and C3, measured immunochemically. Nineteen out of twenty-seven patients with rheumatoid arthritis and four out of four cases of systemic lupus erythematosus (SLE) or SLE-like syndromes had a depressed CH50 value in the synovial fluid, while ten cases with a non-rheumatoid form of arthritis all had normal activity.

The total C activity in serum was normal or increased in most cases. While no correlation was found between CH50 and C3 in serum, there was a statistically highly significant correlation in synovial fluid, indicating that C3 determinations can be used to reveal alterations in C activity of synovial fluid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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