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. 1970 Jan;6(1):75–86.

Studies on eosinophil leucocyte migration. I. Eosinophil and neutrophil accumulation following antigen–antibody reactions in guinea-pig skin

A B Kay
PMCID: PMC1712766  PMID: 5416353

Abstract

Eosinophil leucocytes migrated into the site of PCA reactions mediated by those fractions of 7S guinea-pig IgG containing IgG1; neutrophils were associated with IgG1 and IgG2. Maximal eosinophil infiltration is seen at 12 hr and was associated with degranulation.

Intradermal histamine was not eosinophilotactic in guinea-pigs.

Preformed antigen–antibody complexes of IgG1 and IgG2 both promoted eosinophil and neutrophil migration in guinea-pig skin but slightly more eosinophils were seen following injections of complexes containing IgG1. Local eosinophilia and PCA activity were mediated by a relatively heat-stable element since these effects were demonstrable even after prolonged heating of fractions containing IgG1. Eosinophils were seen following injections of Compound 48/80 and this was accompanied by low mast cell counts; however, there was also some associated tissue destruction.

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Selected References

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