Abstract
The effect of rinderpest virus on the immune response of rabbits to subsequently administered chicken erythrocytes has been investigated as a means of assessing the effects of this virus on general immunological responsiveness.
A significant depression of the primary response was consistently found in those rabbits which became febrile following viral inoculation. In some cases this inhibitory effect extended to the secondary immune response to the same antigen given approximately 3 weeks after the virus.
The degree of immune depression did not appear to be related to the concentration of virus administered.
These observations are discussed in relation to the pathogenesis of Rinderpest and other myxovirus infections.
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Selected References
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