Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1970 Dec;7(6):833–838.

Selective IgA deficiency and autoimmunity

A J Ammann, R Hong
PMCID: PMC1712864  PMID: 4099671

Abstract

Laboratory and clinical data are presented in fifteen patients under the age of sixteen years with selective IgA deficiency, all of whom had normal serum IgG, IgM, IgD and IgE. Results indicate a high incidence of autoimmune disease, autoimmune phenomenon or unusual antibody formation. Three patients had thyroiditis, one cerebral vasculitis, one pulmonary haemosiderosis, one cystic fibrosis and nine had recurrent upper respiratory tract infections. Ten out of fifteen were positive for one or more `autoantibodies.' Selective IgA deficiency cannot always be considered a benign entity and individuals with this defect warrant complete investigation.

Full text

PDF
834

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Cain W. A., Ishizaka K., Hong R., Good R. A. Immunoglobulin E deficiency in ataxia-telangiectasia. N Engl J Med. 1969 Aug 28;281(9):469–472. doi: 10.1056/NEJM196908282810904. [DOI] [PubMed] [Google Scholar]
  2. Buckley R. H., Dees S. C. Correlation of milk precipitins with IgA deficiency. N Engl J Med. 1969 Aug 28;281(9):465–469. doi: 10.1056/NEJM196908282810903. [DOI] [PubMed] [Google Scholar]
  3. CROWLE A. J. A simplified micro double-diffusion agar precipitin technique. J Lab Clin Med. 1958 Nov;52(5):784–787. [PubMed] [Google Scholar]
  4. Cassidy J. T., Burt A., Petty R., Sullivan D. Selective IgA deficiency in connective tissue diseases. N Engl J Med. 1969 Jan 30;280(5):275–275. doi: 10.1056/nejm196901302800520. [DOI] [PubMed] [Google Scholar]
  5. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  6. FRIOU G. Fluorescent spot test for anti-nuclear antibodies. Arthritis Rheum. 1962 Aug;5:407–410. doi: 10.1002/art.1780050409. [DOI] [PubMed] [Google Scholar]
  7. Fraser K. J. IgA immunoglobulins and autoimmunity. Lancet. 1969 Oct 11;2(7624):804–805. doi: 10.1016/s0140-6736(69)90523-6. [DOI] [PubMed] [Google Scholar]
  8. Goldberg L. S., Barnett E. V., Fudenberg H. H. Selective absence of IgA: a family study. J Lab Clin Med. 1968 Aug;72(2):204–212. [PubMed] [Google Scholar]
  9. Hobbs J. R. Immune imbalance in dysgammaglobulinaemia type IV. Lancet. 1968 Jan 20;1(7534):110–114. doi: 10.1016/s0140-6736(68)92721-9. [DOI] [PubMed] [Google Scholar]
  10. Hong R., Good R. A. Limited heterogeneity of gamma globulin in hypogammaglobulinemia. Science. 1967 May 26;156(3778):1102–1103. doi: 10.1126/science.156.3778.1102. [DOI] [PubMed] [Google Scholar]
  11. Ishizaka K., Ishizaka T. Induction of erythema-wheal reactions by soluble antigen-gammaE antibody complexes in humans. J Immunol. 1968 Jul;101(1):68–78. [PubMed] [Google Scholar]
  12. Johansson S. G., Högman C. F., Killander J. Quantitative immunoglobulin determination. Comparison of two methods. Estimation of normal levels and levels in persons lacking IgA and IgD. Acta Pathol Microbiol Scand. 1968;74(4):519–530. [PubMed] [Google Scholar]
  13. Lerner R. A., Dixon F. J. The induction of acute glomerulonephritis in rabbits with soluble antigens isolated from normal homologous and autologous urine. J Immunol. 1968 Jun;100(6):1277–1287. [PubMed] [Google Scholar]
  14. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  15. Peterson R. D., Cooper M. D., Good R. A. Lymphoid tissue abnormalities associated with ataxia-telangiectasia. Am J Med. 1966 Sep;41(3):342–359. doi: 10.1016/0002-9343(66)90080-5. [DOI] [PubMed] [Google Scholar]
  16. ROCKEY J. H., HANSON L. A., HEREMANS J. F., KUNKEL H. G. BETA-2A AGLOBULINEMIA IN TWO HEALTHY MEN. J Lab Clin Med. 1964 Feb;63:205–212. [PubMed] [Google Scholar]
  17. Rothberg R. M. Immunoglobulin and specific antibody synthesis during the first weeks of life of premature infants. J Pediatr. 1969 Sep;75(3):391–399. doi: 10.1016/s0022-3476(69)80264-7. [DOI] [PubMed] [Google Scholar]
  18. Vyas G. N., Holmdahl L., Perkins H. A., Fudenberg H. H. Serologic specificity of hun anti-IgA and its significance in transfusion. Blood. 1969 Nov;34(5):573–581. [PubMed] [Google Scholar]
  19. WEST C. D., HONG R., HOLLAND N. H. Immunoglobulin levels from the newborn period to adulthood and in immunoglobulin deficiency states. J Clin Invest. 1962 Nov;41:2054–2064. doi: 10.1172/JCI104663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. van Munster P. J., Stoelinga G. B. Over de isolering en de bepaling van immuunglobuline-A (IgA) Maandschr Kindergeneeskd. 1965 Nov;33(11):428–443. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES