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. 1970 Dec;7(6):897–902.

`False positive' precipitation reactions to extracts of organic dusts due to a techoic acid from S. aureus

Jennifer A Faux, Valerie Holford-Strevens, I D Wells, J Pepys
PMCID: PMC1712877  PMID: 4099672

Abstract

Precipitation reactions regarded as `false positive' have been obtained to extracts of a variety of organic dusts. The antigen responsible for these reactions is an electrophoretically fast moving and negatively charged substance, previously observed in extracts of mouldy hay and other vegetable and organic dusts, and referred to as a `D line' antigen. This antigen has now been shown to have antigenic determinants in common with a β-teichoic acid prepared from Staphylococcus aureus. Absorption of the sera with N-acetyl-D-glucosamine had an inhibitory effect on `D line' and teichoic acid precipitin reactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BADDILEY J., BUCHANAN J. G., MARTIN R. O., RAJBHANDARY U. L. Teichoic acid from the walls of Staphylococcus aureus H. 2. Location of phosphate and alanine residues. Biochem J. 1962 Oct;85:49–56. doi: 10.1042/bj0850049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HAUKENES G. Immunochemical studies on polysaccharide A of Staphylococcus aureus. 5. Identification of amino sugars and amino acids. Acta Pathol Microbiol Scand. 1962;55:308–318. doi: 10.1111/j.1699-0463.1962.tb04130.x. [DOI] [PubMed] [Google Scholar]
  3. HAUKENES G. Immunochemical studies on polysaccharide A of Staphylococcus aureus. 7. On the chemical basis of the serological reactivity and the nature of the extraction process. Acta Pathol Microbiol Scand. 1962;55:463–474. [PubMed] [Google Scholar]
  4. Hargreave F. E., Pepys J., Longbottom J. L., Wraith D. G. Bird breeder's (fancier's) lung. Lancet. 1966 Feb 26;1(7435):445–449. doi: 10.1016/s0140-6736(66)91454-1. [DOI] [PubMed] [Google Scholar]
  5. Hearn C. E., Holford-Strevens V. Immunological aspects of bagassosis. Br J Ind Med. 1968 Oct;25(4):283–292. doi: 10.1136/oem.25.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holford-Strevens V., Wide L., Milne J. F., Pepys J. Allergens and antigens of Dermatophagoides farinae. Clin Exp Immunol. 1970 Jan;6(1):49–59. [PMC free article] [PubMed] [Google Scholar]
  7. LEVY H. B., SOBER H. A. A simple chromatographic method for preparation of gamma globulin. Proc Soc Exp Biol Med. 1960 Jan;103:250–252. doi: 10.3181/00379727-103-25476. [DOI] [PubMed] [Google Scholar]
  8. Martin R. R., Daugharty H., White A. Staphylococcal antibodies and hypersensitivity to teichoic acids in man. Antimicrob Agents Chemother (Bethesda) 1965;5:91–96. [PubMed] [Google Scholar]
  9. PEPYS J., JENKINS P. A., FESTENSTEIN G. N., GREGORY P. H., LACEY M. E., SKINNER F. A. FARMER'S LUNG. THERMOPHILIC ACTINOMYCETES AS A SOURCE OF "FARMER'S LUNG HAY" ANTIGEN. Lancet. 1963 Sep 21;2(7308):607–611. doi: 10.1016/s0140-6736(63)90398-2. [DOI] [PubMed] [Google Scholar]
  10. PEPYS J., LONGBOTTOM J. L., JENKINS P. A. VEGETABLE DUST PNEUMOCONIOSES. IMMUNOLOGIC RESPONSES TO VEGETABLE DUSTS AND THEIR FLORA. Am Rev Respir Dis. 1964 Jun;89:842–858. doi: 10.1164/arrd.1964.89.6.842. [DOI] [PubMed] [Google Scholar]
  11. REED C. E., BARBEE R. A. PIGEON-BREEDERS' LUNG: A NEWLY OBSERVED INTERSTITIAL PULMONARY DISEASE. JAMA. 1965 Jul 26;193:261–265. doi: 10.1001/jama.1965.03090040005001. [DOI] [PubMed] [Google Scholar]
  12. SANDERSON A. R., STROMINGER J. L., NATHENSON S. G. Chemical structure of teichoic acid from Staphylococcus aureus, strain Copenhagen. J Biol Chem. 1962 Dec;237:3603–3613. [PubMed] [Google Scholar]
  13. SINGLETON L., ROSS G. W., KOHN J. STAPHYLOCOCCAL TEICHOIC ACID ANTIBODY IN THE SERA OF PATIENTS WITH BURNS. Nature. 1964 Sep 12;203:1173–1174. doi: 10.1038/2031173a0. [DOI] [PubMed] [Google Scholar]
  14. Salvaggio J., Arquembourg P., Seabury J., Buechner H. Bagassosis. IV. Precipitins against extracts of thermophilic actinomycetes in patients with bagassosis. Am J Med. 1969 Apr;46(4):538–544. doi: 10.1016/0002-9343(69)90073-4. [DOI] [PubMed] [Google Scholar]
  15. TORII M., KABAT E. A., BEZER A. E. SEPARATION OF TEICHOIC ACID OF STAPHYLOCOCCUS AUREUS INTO TWO IMMUNOLOGICALLY DISTINCT SPECIFIC POLYSACCHARIDES WITH ALPHA- AND BETA-N-ACETYLGLUCOSAMINYL LINKAGES RESPECTIVELY. ANTIGENICITY OF THEICHOIC ACIDS IN MAN. J Exp Med. 1964 Jul 1;120:13–29. doi: 10.1084/jem.120.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]

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