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. 1971 Jan;8(1):131–139.

Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene

J R Frey, A L De Weck, H Geleick
PMCID: PMC1712905  PMID: 5540549

Abstract

When guinea-pigs showing a high degree of contact sensitivity to dinitrochlorobenzene (DNCB) were injected intravenously with a related hapten, dinitrobenzene sulphonic acid sodium salt (DNBSO3), the animals became totally unresponsive for 1 to 4 days and remained thereafter in a state of diminished sensitivity, lasting for 8 weeks. No lasting total unresponsiveness was achieved by an additional intradermal injection of DNCB (or various variations thereof) performed 6 hr after the intravenous injection (`double shot' procedure), in contrast to what had been observed in the Neoarsphenamine and potassium dichromate system. The effect of the intravenous injection of DNBSO3 is attributed to a temporary disappearance of the sensitized lymphoid cells from the circulation, whereas the induction of a permanent unresponsiveness certainly requires some additional mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FREY J. R., DE WECK A. L., GELEICK H. IMMUNOLOGICAL UNRESPONSIVENESS IN ALLERGIC CONTACT DEMATITIS TO DINITROCHLOROBENZENE IN GUINEA PIGS. J Invest Dermatol. 1964 Jan;42:41–47. doi: 10.1038/jid.1964.11. [DOI] [PubMed] [Google Scholar]
  2. FREY J. R., DEWECK A. L., GELEICK H. INHIBITION OF THE CONTACT REACTION TO DINITROCHLOROBENZENE BY INTRAVENOUS INJECTION OF DINITROBENZENE SULFONATE IN GUINEA PIGS SENSITIZED TO DINITROCHLOROBENZENE. J Invest Dermatol. 1964 Feb;42:189–196. doi: 10.1038/jid.1964.41. [DOI] [PubMed] [Google Scholar]
  3. FREY J. R., GELEICK H., DEWECK A. IMMUNOLOGICAL TOLERANCE INDUCED IN ANIMALS PREVIOUSLY SENSITIZED TO SIMPLE CHEMICAL COMPOUNDS. Science. 1964 May 15;144(3620):853–854. doi: 10.1126/science.144.3620.853. [DOI] [PubMed] [Google Scholar]
  4. FREY J. R., GELEICK H. [Desensitization by intravenous injection of dinitrochlorbenzene in contact eczema in guinea pigs]. Dermatologica. 1962;125:132–139. [PubMed] [Google Scholar]
  5. Frey J. R., de Weck A. L., Geleick H. Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. IV. Desensitization to NEO. Int Arch Allergy Appl Immunol. 1966;30(6):521–537. doi: 10.1159/000229839. [DOI] [PubMed] [Google Scholar]
  6. Polák L., Turk J. L. Studies on the effect of systemic administration of sensitizers in guinea-pigs with contact sensitivity to inorganic metal compounds. 3. The effect of immunosuppressive agents on enhancing the unresponsiveness of already sensitized animals and an investigation of the action of the epicutaneous test within twenty-four hours. Clin Exp Immunol. 1969 Apr;4(4):423–434. [PMC free article] [PubMed] [Google Scholar]
  7. Waldorf D. S., Haynes H. A., Van Scott E. J. Cutaneous hypersensitivity and desensitization to mechlorethamine in patients with mycosis fungoides lymphoma. Ann Intern Med. 1967 Aug;67(2):282–290. doi: 10.7326/0003-4819-67-2-282. [DOI] [PubMed] [Google Scholar]

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