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. 1971 Mar;8(3):427–434.

In vitro response of foetal lymphocytes to PHA, and a factor plasma which suppresses the PHA response of adult lymphocytes

J Ayoub, S Kasakura
PMCID: PMC1712926  PMID: 5576662

Abstract

The in vitro response of cord blood lymphocytes from full-term newborn infants and premature infants to phytohaemagglutinin (PHA) stimulation was investigated. The effect of foetal plasma on adult cellular reactivity also was studied. It was shown that foetal lymphocytes suspended in either foetal or adult plasma reacted significantly less than adult cells in adult plasma. Adult cells suspended in foetal plasma showed a significant suppression of reactivity as compared with adult cells in adult plasma. It seems that foetal plasma contains a factor which suppresses the response of adult lymphocytes to PHA stimulation. At the present, the nature of this inhibitory factor is unknown. However, our demonstration of the relationship between the level of α1-fetoglycoprotein (fetuin) and inhibitory activity in premature plasma would suggest that fetuin in foetal plasma might be responsible for its inhibitory activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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