Abstract
Antinuclear antibodies were looked for in the leucocytes from synovial effusions of subjects with inflammatory arthritis. Antinuclear antibodies were found concentrated in the lysates of synovial fluid leucocytes from five of seven effusions of adults with rheumatoid arthritis, and in low titres from a patient with Reiter's syndrome. In three subjects the antinuclear antibody was detected in cell lysates when it was not demonstrable in the corresponding synovial fluid. These findings are interpreted as evidence that antinuclear antibodies play a role in articular inflammation.
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Selected References
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