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. 1971 Jun;8(6):901–909.

A study of cell mediated immunity in leprosy: changing trends in the immunological spectrum of the disease

Kunal Saha, M M Mittal
PMCID: PMC1713046  PMID: 5091616

Abstract

Skin tests of delayed hypersensitivity were performed on thirty-eight patients of leprosy with a bacterial antigen (tuberculin), a hapten (dinitrochlorobenzene) and allogenic lymphocytic transplantation. The results have indicated that leprosy is associated with a generalized depression of delayed allergic response. The depression is of greater severity in patients with lepromatous leprosy and less among tuberculoid patients. The depression of cell mediated immunity in these cases is not absolute but is relative and depends upon the dose and potency of an antigen and the severity of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRENT L., MEDAWAR P. B. Tissue transplantation: a new approach to the "typing" problem. Br Med J. 1963 Aug 3;2(5352):269–272. doi: 10.1136/bmj.2.5352.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BUCK A. A., HASENCLEVER H. F. The influence of leprosy on delayed-type skin reactions and serum agglutination titers to Candida albicans. A comparative study of patients with lepromatous and tuberculoid leprosy and controls in Ethiopia. Am J Hyg. 1963 May;77:305–316. doi: 10.1093/oxfordjournals.aje.a120321. [DOI] [PubMed] [Google Scholar]
  3. Dierks R. E., Shepard C. C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc Soc Exp Biol Med. 1968 Feb;127(2):391–395. doi: 10.3181/00379727-127-32698. [DOI] [PubMed] [Google Scholar]
  4. GOLDSMITH K. L. DONOR SELECTION AND COMPATIBILITY TYPING. Br Med Bull. 1965 May;21:162–PASSIM. doi: 10.1093/oxfordjournals.bmb.a070386. [DOI] [PubMed] [Google Scholar]
  5. GUINTO R. S., MABALAY M. C. A note on the tuberculin reaction in leprosy. Int J Lepr. 1962 Jul-Sep;30:278–283. [PubMed] [Google Scholar]
  6. KARUSH F., EISEN H. N. A theory of delayed hypersensitivity. Science. 1962 Jun 22;136(3521):1032–1039. doi: 10.1126/science.136.3521.1032. [DOI] [PubMed] [Google Scholar]
  7. Leiker D. L. Intradermal tests with mycobacterial substances and normal tissue suspensions. Int J Lepr Other Mycobact Dis. 1968 Jan-Mar;36(1):52–59. [PubMed] [Google Scholar]
  8. Lischner H. W., Dacou C., DiGeorge A. M. Normal lymphocyte transfer (NLT) test: negative response in a patient with congenital absence of the thymus. Transplantation. 1967 May;5(3):555–557. [PubMed] [Google Scholar]
  9. RIDLEY D. S., JOPLING W. H. A classification of leprosy for research purposes. Lepr Rev. 1962 Apr;33:119–128. doi: 10.5935/0305-7518.19620014. [DOI] [PubMed] [Google Scholar]
  10. Rodriguez Paradisi E., de Bonaparte Y. P., Morgenfeld M. C. Blasts in lepromatous leprosy. Lancet. 1968 Feb 10;1(7537):308–309. doi: 10.1016/s0140-6736(68)90173-6. [DOI] [PubMed] [Google Scholar]
  11. Sheagren J. N., Block J. B., Trautman J. R., Wolff S. M. Immunologic reactivity in patients with leprosy. Ann Intern Med. 1969 Feb;70(2):295–302. doi: 10.7326/0003-4819-70-2-295. [DOI] [PubMed] [Google Scholar]
  12. Turk J. L., Waters M. F. Cell-mediated immunity in patients with leprosy. Lancet. 1969 Aug 2;2(7614):243–246. doi: 10.1016/s0140-6736(69)90009-9. [DOI] [PubMed] [Google Scholar]
  13. Waldorf D. S., Sheagren J. N., Trautman J. R., Block J. B. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966 Oct 8;2(7467):773–776. doi: 10.1016/s0140-6736(66)90366-7. [DOI] [PubMed] [Google Scholar]

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