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. 1972 Apr;10(4):635–647.

Individual antigenic specificity and cross-reactions among amyloid preparations from different individuals

G Husby, J B Natvig
PMCID: PMC1713113  PMID: 4624554

Abstract

Amyloid fibrils were isolated from eleven amyloid-laden organs of six patients. By alkaline degradation, soluble units were obtained which gave antibody formation in rabbits. Gel precipitation and haemagglutination inhibition were used to characterize antigens of the amyloid. Evidence was obtained that amyloids from different organs of the same individual were identical in the antigenicity. In contrast, amyloids from different individuals each showed unique individual specificity. Besides this, antigenic cross-reactions were noted between the amyloid preparations. Finally, evidence for antigenic cross-reactivity between certain amyloid preparations and immunoglobulin light chains was obtained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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