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. 1981 Sep;39(3):808–815. doi: 10.1128/jvi.39.3.808-815.1981

Lack of AKR ecotropic provirus amplification in AKR leukemic thymuses.

F K Yoshimura, M Breda
PMCID: PMC171313  PMID: 6270352

Abstract

A DNA fragment from the 3' region of a molecularly cloned AKR ecotropic provirus was identified to be specific for the AKR ecotropic murine leukemia virus (MuLV). This selected DNA fragment was used to analyze the integrated MuLV proviruses in normal and leukemic tissue DNAs of AKR mice. In comparison with a DNA fragment from the 5' region of the cloned AKR genome or one representing the entire genome, this selected probe hybridized to only a few MuLV proviruses. By comparing transformed and nontransformed tissue DNAs, it appeared that no amplification of proviral sequences related to the AKR ecotropic MuLV had occurred in thymomas of AKR mice during the development of leukemia in these animals. Analysis of the AKR ecotropic MuLV proviruses revealed a significant degree of polymorphism for these sequences among individuals in the AKR/J strain of mouse.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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