Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1971 Dec;9(6):753–760.

Human antibodies to vascular endothelium

K J Lindqvist, C K Osterland
PMCID: PMC1713138  PMID: 4945736

Abstract

Certain human sera were found to produce specific staining of vascular endothelium by the immunofluorescent technique. The antibody nature of this reaction was confirmed by using fluorescein-conjugated antisera specific for human immunoglobulins and the component of complement, and by physicochemical characterization of isolated immunoglobulins giving this reaction. This activity was present in sera from patients with a wide variety of diseases (17·8%). The highest incidence was found in chronic pulmonary tuberculosis (26·6%). An incidence of 14% was found in presumably normal blood donors. The stimulus for the production of these antibodies is unknown. The antigen is fairly widely distributed among different species, since tissues from a variety of animals could be used as substrate in the reaction. Experiments have shown that neither the classic Forssman antigen nor ABO blood groups are involved. The possible role of these antibodies in human disease remains to be elucidated. The finding of anti-endothelial activity in two recipients of renal transplants may be significant.

Full text

PDF
756

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COONS A. H., KAPLAN M. H. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. J Exp Med. 1950 Jan 1;91(1):1–13. doi: 10.1084/jem.91.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HOROWITZ R. E., BURROWS L., PARONETTO F., DREILLING D., KARK A. E. IMMUNOLOGIC OBSERVATIONS ON HOMOGRAFTS. II. THE CANINE KIDNEY. Transplantation. 1965 May;3:318–325. doi: 10.1097/00007890-196505000-00002. [DOI] [PubMed] [Google Scholar]
  3. Henle G., Henle W., Diehl V. Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis. Proc Natl Acad Sci U S A. 1968 Jan;59(1):94–101. doi: 10.1073/pnas.59.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Klassen J., Milgrom F. Autoimmune concomitants of renal allografts. Transplant Proc. 1969 Mar;1(1):605–608. [PubMed] [Google Scholar]
  5. Lindqvist K. J., Coleman R. E., Osterland C. K. Autoantibodies in chronic pulmonary tuberculosis. J Chronic Dis. 1970 Apr;22(11):717–725. doi: 10.1016/0021-9681(70)90047-0. [DOI] [PubMed] [Google Scholar]
  6. Niederman J. C., McCollum R. W., Henle G., Henle W. Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies. JAMA. 1968 Jan 15;203(3):205–209. doi: 10.1001/jama.203.3.205. [DOI] [PubMed] [Google Scholar]
  7. PORTER K. A., PEART W. S., KENYON J. R., JOSEPH N. H., HOEHN R. J., CALNE R. Y. REJECTION OF KIDNEY HOMOTRANSPLANTS. Ann N Y Acad Sci. 1964 Nov 30;120:472–495. doi: 10.1111/j.1749-6632.1964.tb34746.x. [DOI] [PubMed] [Google Scholar]
  8. Rapaport F. T., Kano K., Milgrom F. Heterophile antibodies in human transplantation. J Clin Invest. 1968 Mar;47(3):633–642. doi: 10.1172/JCI105759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SZULMAN A. E. The histological distribution of blood group substances A and B in man. J Exp Med. 1960 Jun 1;111:785–800. doi: 10.1084/jem.111.6.785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Whittingham S., Mackay I. R., Irwin J. Autoimmune hepatitis. Immunofluorescence reactions with cytoplasm of smooth muscle and renal glomerular cells. Lancet. 1966 Jun 18;1(7451):1333–1335. doi: 10.1016/s0140-6736(66)92131-3. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES