Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1972 Mar;10(3):427–434.

Immunoglobulin levels and antibody to candida albicans in human cervicovaginal secretions

R H Waldman, J M Cruz, D S Rowe
PMCID: PMC1713147  PMID: 4556009

Abstract

Human cervicovaginal secretions were examined for immunoglobulin content and for antibody to Candida albicans. The predominant immunoglobulin class of the secretions was IgA, accounting for approximately 65% of the total immunoglobulin. Most of the IgA was eluted from Sephadex G-200 in the excluded peak and was associated with secretory component; it therefore had the characteristics of `secretory IgA'. With increasing age, the IgA content fell and the IgG content rose in cervicovaginal secretions. No IgE could be detected in the secretions. Antibody to C. albicans was found to be predominantly of the IgA class.

Full text

PDF
427

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alford R. H. Effects of chronic bronchopulmonary disease and aging on human nasal secretion IgA concentrations. J Immunol. 1968 Nov;101(5):984–988. [PubMed] [Google Scholar]
  2. CHODIRKER W. B., TOMASI T. B., Jr GAMMA-GLOBULINS: QUANTITATIVE RELATIONSHIPS IN HUMAN SERUM AND NONVASCULAR FLUIDS. Science. 1963 Nov 22;142(3595):1080–1081. doi: 10.1126/science.142.3595.1080. [DOI] [PubMed] [Google Scholar]
  3. Hulka J. F., Omran K. F. The uterine cervix as a potential local antibody secretor. Am J Obstet Gynecol. 1969 Jun 1;104(3):440–442. doi: 10.1016/s0002-9378(16)34202-8. [DOI] [PubMed] [Google Scholar]
  4. Johnson H. M., Brenner K., Hall H. E. The use of a wate-soluble carbodiimide as a coupling reagent in the passive hemagglutination test. J Immunol. 1966 Dec;97(6):791–796. [PubMed] [Google Scholar]
  5. Masson P. L., Heremans J. F., Férin J. Clinical importance of the biochemical changes in the female genital tract. I. Studies on the proteins of cervical mucus. Int J Fertil. 1969 Jan-Mar;14(1):1–7. [PubMed] [Google Scholar]
  6. McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
  7. Mestecky J., Kraus F. W., Voight S. A. Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant. Immunology. 1970 Feb;18(2):237–243. [PMC free article] [PubMed] [Google Scholar]
  8. Parish W. E., Carron-Brown J. A., Richards C. B. The detection of antibodies to spermatozoa and to blood group antigens in cervical mucus. J Reprod Fertil. 1967 Jun;13(3):469–483. doi: 10.1530/jrf.0.0130469. [DOI] [PubMed] [Google Scholar]
  9. Rossen R. D., Butler W. T., Cate T. R., Szwed C. F., Couch R. B. Protein composition of nasal secretion during respiratory virus infection. Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1169–1176. doi: 10.3181/00379727-119-30406. [DOI] [PubMed] [Google Scholar]
  10. Rowe D. S., Anderson S. G., Grab B. A research standard for human serum immunoglobulins IgG, IgA and IgM. Bull World Health Organ. 1970;42(4):535–552. [PMC free article] [PubMed] [Google Scholar]
  11. Rowe D. S. Radioactive single radial diffusion: a method for increasing the sensitivity of immunochemical quantification of proteins in agar gel. Bull World Health Organ. 1969 Apr;40(4):613–616. [PMC free article] [PubMed] [Google Scholar]
  12. STRAUS E. K. SPERM IMMOBILIZATION IN THE HUMAN VAGINA BY INDUCED MUCOANTIBODY. Fertil Steril. 1965 May-Jun;16:346–355. doi: 10.1016/s0015-0282(16)35588-1. [DOI] [PubMed] [Google Scholar]
  13. Tomasi T. B., Jr, Bienenstock J. Secretory immunoglobulins. Adv Immunol. 1968;9:1–96. doi: 10.1016/s0065-2776(08)60441-1. [DOI] [PubMed] [Google Scholar]
  14. Tourville D. R., Ogra S. S., Lippes J., Tomasi T. B., Jr The human female reproductive tract: immunohistological localization of gamma A, gamma G, gamma M, secretory "piece," and lactoferrin. Am J Obstet Gynecol. 1970 Dec 1;108(7):1102–1108. doi: 10.1016/0002-9378(70)90460-6. [DOI] [PubMed] [Google Scholar]
  15. Waldman R. H., Mach J. P., Stella M. M., Rowe D. S. Secretory IgA in human serum. J Immunol. 1970 Jul;105(1):43–47. [PubMed] [Google Scholar]
  16. YAGI Y., MAIER P., PRESSMAN D., ARBESMAN C. E., REISMAN R. E. THE PRESENCE OF THE RAGWEED-BINDING ANTIBODIES IN THE BETA-2A, BETA-2M, AND GAMMA GLOBULINS OF THE SENSITIVE INDIVIDUALS. J Immunol. 1963 Jul;91:83–89. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES