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. 1989 May;44(5):679–685.

An intronic region within the human factor VIII gene is duplicated within Xq28 and is homologous to the polymorphic locus DXS115 (767)

M Patterson, J Gitschier, J Bloomfield, M Bell, H Dorkins, U Froster-Iskenius, S Sommer, J Sobell, D Schaid, S Thibodeau, K E Davies
PMCID: PMC1715651  PMID: 2565080

Abstract

The genomic sequences recognized by the anonymous probe 767 (DXS115) are localized to two sites within Xq28. One site lies within intron 22 of the factor VIII gene (FBC). Physical mapping suggests that the second site lies within 1.2 megabases of the F8C gene. The RFLPs detected by 767 are located within the second site. Genetic data suggest that F8C and DXS115 are tightly linked (θmax = .04; Zmax = 8.30). Recombination events in meioses informative for DXS52 (Stl4), DXS115, and F8C suggest that DXS115 and F8C lie distal to DXS52.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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