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. 1997 Nov;61(5):995–999. doi: 10.1086/301617

Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination.

J A Tischfield 1
PMCID: PMC1716040  PMID: 9345110

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bezzubova O., Silbergleit A., Yamaguchi-Iwai Y., Takeda S., Buerstedde J. M. Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line. Cell. 1997 Apr 18;89(2):185–193. doi: 10.1016/s0092-8674(00)80198-1. [DOI] [PubMed] [Google Scholar]
  2. Cappione A. J., French B. L., Skuse G. R. A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. Am J Hum Genet. 1997 Feb;60(2):305–312. [PMC free article] [PubMed] [Google Scholar]
  3. Ceci J. D. Encyclopedia of the mouse genome V. Mouse chromosome 8. Mamm Genome. 1996;6(Spec No):S151–S169. [PubMed] [Google Scholar]
  4. De Sepulveda P., Guenet J. L., Panthier J. J. Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice. Mol Cell Biol. 1995 Nov;15(11):5898–5905. doi: 10.1128/mcb.15.11.5898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Engle S. J., Stockelman M. G., Chen J., Boivin G., Yum M. N., Davies P. M., Ying M. Y., Sahota A., Simmonds H. A., Stambrook P. J. Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5307–5312. doi: 10.1073/pnas.93.11.5307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Essers J., Hendriks R. W., Swagemakers S. M., Troelstra C., de Wit J., Bootsma D., Hoeijmakers J. H., Kanaar R. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell. 1997 Apr 18;89(2):195–204. doi: 10.1016/s0092-8674(00)80199-3. [DOI] [PubMed] [Google Scholar]
  7. Fujimori A., Tachibana A., Tatsumi K. Allelic losses in mutations at the aprt locus of human lymphoblastoid cells. Mutat Res. 1992 Sep;269(1):55–62. doi: 10.1016/0027-5107(92)90160-4. [DOI] [PubMed] [Google Scholar]
  8. Gupta P. K., Sahota A., Boyadjiev S. A., Bye S., Shao C., O'Neill J. P., Hunter T. C., Albertini R. J., Stambrook P. J., Tischfield J. A. High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. Cancer Res. 1997 Mar 15;57(6):1188–1193. [PubMed] [Google Scholar]
  9. Gupta P. K., Shao C., Zhu Y., Sahota A., Tischfield J. A. Loss of heterozygosity analysis in a human fibrosarcoma cell line. Cytogenet Cell Genet. 1997;76(3-4):214–218. doi: 10.1159/000134552. [DOI] [PubMed] [Google Scholar]
  10. Jackson S. P., Jeggo P. A. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem Sci. 1995 Oct;20(10):412–415. doi: 10.1016/s0968-0004(00)89090-8. [DOI] [PubMed] [Google Scholar]
  11. Jonkman M. F., Scheffer H., Stulp R., Pas H. H., Nijenhuis M., Heeres K., Owaribe K., Pulkkinen L., Uitto J. Revertant mosaicism in epidermolysis bullosa caused by mitotic gene conversion. Cell. 1997 Feb 21;88(4):543–551. doi: 10.1016/s0092-8674(00)81894-2. [DOI] [PubMed] [Google Scholar]
  12. Kinzler K. W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996 Oct 18;87(2):159–170. doi: 10.1016/s0092-8674(00)81333-1. [DOI] [PubMed] [Google Scholar]
  13. Knudson A. G. Antioncogenes and human cancer. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10914–10921. doi: 10.1073/pnas.90.23.10914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kushiro J., Hirai Y., Kusunoki Y., Kyoizumi S., Kodama Y., Wakisaka A., Jeffreys A., Cologne J. B., Dohi K., Nakamura N. Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphocytes. Mutat Res. 1992 Aug;272(1):17–29. doi: 10.1016/0165-1161(92)90005-7. [DOI] [PubMed] [Google Scholar]
  15. Levine A. J. p53, the cellular gatekeeper for growth and division. Cell. 1997 Feb 7;88(3):323–331. doi: 10.1016/s0092-8674(00)81871-1. [DOI] [PubMed] [Google Scholar]
  16. Loeb L. A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 1991 Jun 15;51(12):3075–3079. [PubMed] [Google Scholar]
  17. Morley A. A. Mitotic recombination in mammalian cells in vivo. Mutat Res. 1991 Sep-Oct;250(1-2):345–349. doi: 10.1016/0027-5107(91)90191-p. [DOI] [PubMed] [Google Scholar]
  18. Moynahan M. E., Jasin M. Loss of heterozygosity induced by a chromosomal double-strand break. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):8988–8993. doi: 10.1073/pnas.94.17.8988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Phear G., Bhattacharyya N. P., Meuth M. Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. Mol Cell Biol. 1996 Nov;16(11):6516–6523. doi: 10.1128/mcb.16.11.6516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Qian F., Germino G. G. "Mistakes happen": somatic mutation and disease. Am J Hum Genet. 1997 Nov;61(5):1000–1005. doi: 10.1086/301618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sengstag C. The molecular mechanism of aflatoxin B1-induced liver cancer: is mitotic recombination involved? Mol Carcinog. 1997 Jul;19(3):147–152. [PubMed] [Google Scholar]
  22. Shao C., Gupta P. K., Sun Y., Sahota A., Tischfield J. A. Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells. Cytogenet Cell Genet. 1996;75(4):216–221. doi: 10.1159/000134486. [DOI] [PubMed] [Google Scholar]
  23. Shinohara A., Ogawa T. Homologous recombination and the roles of double-strand breaks. Trends Biochem Sci. 1995 Oct;20(10):387–391. doi: 10.1016/s0968-0004(00)89085-4. [DOI] [PubMed] [Google Scholar]
  24. Smith L. E., Grosovsky A. J. Genetic instability on chromosome 16 in a human B lymphoblastoid cell line. Somat Cell Mol Genet. 1993 Nov;19(6):515–527. doi: 10.1007/BF01233379. [DOI] [PubMed] [Google Scholar]
  25. Stambrook P. J., Shao C., Stockelman M., Boivin G., Engle S. J., Tischfield J. A. APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity. Environ Mol Mutagen. 1996;28(4):471–482. doi: 10.1002/(SICI)1098-2280(1996)28:4<471::AID-EM25>3.0.CO;2-B. [DOI] [PubMed] [Google Scholar]
  26. Tischfield J. A., Ruddle F. H. Assignment of the gene for adenine phosphoribosyltransferase to human chromosome 16 by mouse-human somatic cell hybridization. Proc Natl Acad Sci U S A. 1974 Jan;71(1):45–49. doi: 10.1073/pnas.71.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. de Nooij-van Dalen A. G., van Buuren-van Seggelen V. H., Mulder A., Gelsthorpe K., Cole J., Lohman P. H., Giphart-Gassler M. Isolation and molecular characterization of spontaneous mutants of lymphoblastoid cells with extended loss of heterozygosity. Mutat Res. 1997 Mar 4;374(1):51–62. doi: 10.1016/s0027-5107(96)00218-7. [DOI] [PubMed] [Google Scholar]

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