Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1990 Mar;34(3):470–472. doi: 10.1128/aac.34.3.470

Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine.

D Antoniskis 1, R A Larsen 1
PMCID: PMC171617  PMID: 2334159

Abstract

We report four cases of acute reversible renal failure in patients with acquired immune deficiency syndrome who received both amphotericin B (for systemic mycoses) and pentamidine isethionate (for Pneumocystis carinii pneumonia). The concurrent use of amphotericin B with either inhaled pentamidine or trimethoprim-sulfamethoxazole did not cause significant renal impairment.

Full text

PDF
470

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUTLER W. T., BENNETT J. E., ALLING D. W., WERTLAKE P. T., UTZ J. P., HILL G. J., 2nd NEPHROTOXICITY OF AMPHOTERICIN B; EARLY AND LATE EFFECTS IN 81 PATIENTS. Ann Intern Med. 1964 Aug;61:175–187. doi: 10.7326/0003-4819-61-2-175. [DOI] [PubMed] [Google Scholar]
  2. Conte J. E., Jr, Upton R. A., Lin E. T. Pentamidine pharmacokinetics in patients with AIDS with impaired renal function. J Infect Dis. 1987 Dec;156(6):885–890. doi: 10.1093/infdis/156.6.885. [DOI] [PubMed] [Google Scholar]
  3. Porter G. A., Bennett W. M. Nephrotoxic acute renal failure due to common drugs. Am J Physiol. 1981 Jul;241(1):F1–F8. doi: 10.1152/ajprenal.1981.241.1.F1. [DOI] [PubMed] [Google Scholar]
  4. Sacks P., Fellner S. K. Recurrent reversible acute renal failure from amphotericin. Arch Intern Med. 1987 Mar;147(3):593–595. [PubMed] [Google Scholar]
  5. Sands M., Kron M. A., Brown R. B. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625–634. doi: 10.1093/clinids/7.5.625. [DOI] [PubMed] [Google Scholar]
  6. Sattler F. R., Cowan R., Nielsen D. M., Ruskin J. Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. Ann Intern Med. 1988 Aug 15;109(4):280–287. doi: 10.7326/0003-4819-109-4-280. [DOI] [PubMed] [Google Scholar]
  7. Western K. A., Perera D. R., Schultz M. G. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. Ann Intern Med. 1970 Nov;73(5):695–702. doi: 10.7326/0003-4819-73-5-695. [DOI] [PubMed] [Google Scholar]
  8. Wharton J. M., Coleman D. L., Wofsy C. B., Luce J. M., Blumenfeld W., Hadley W. K., Ingram-Drake L., Volberding P. A., Hopewell P. C. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective randomized trial. Ann Intern Med. 1986 Jul;105(1):37–44. doi: 10.7326/0003-4819-105-1-37. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES