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. 1990 May;34(5):931–933. doi: 10.1128/aac.34.5.931

Sucralfate significantly reduces ciprofloxacin concentrations in serum.

J C Garrelts 1, P J Godley 1, J D Peterie 1, E H Gerlach 1, C C Yakshe 1
PMCID: PMC171725  PMID: 2360833

Abstract

The effect of sucralfate on the bioavailability of ciprofloxacin was evaluated in eight healthy subjects utilizing a randomized, crossover design. The area under the concentration-time curve from 0 to 12 h was reduced from 8.8 to 1.1 micrograms.h/ml by sucralfate (P less than 0.005). Similarly, the maximum concentration of ciprofloxacin in serum was reduced from 2.0 to 0.2 micrograms/ml (P less than 0.005). We conclude that concurrent ingestion of sucralfate significantly reduces the concentrations in serum produced by a 500-mg dose of ciprofloxacin. On the basis of these findings, ciprofloxacin and sucralfate should not be administered concurrently.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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