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. 1990 Jun;34(6):1290–1293. doi: 10.1128/aac.34.6.1290

Failure of ceftazidime-amikacin therapy for bacteremia and meningitis due to Klebsiella pneumoniae producing an extended-spectrum beta-lactamase.

C E Smith 1, B S Tillman 1, A W Howell 1, R N Longfield 1, J H Jorgensen 1
PMCID: PMC171806  PMID: 2203306

Abstract

A multiple trauma patient failed treatment with ceftazidime and amikacin for bacteremia and meningitis due to a Klebsiella pneumoniae strain that produced a novel, plasmid-mediated beta-lactamase. Both pre- and posttreatment isolates were resistant to ceftazidime (MIC, greater than or equal to 64 micrograms/ml) and various penicillins but not to other expanded-spectrum cephalosporins. The beta-lactamase had a pI of 5.25 and was encoded on a conjugal plasmid of approximately 150 kilobases. DNA hybridization studies indicated that the enzyme was a TEM derivative.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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