Abstract
Pentamidine isethionate was bacteriostatic against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus sanguis, Micrococcus sp., and Candida albicans. S. aureus was inhibited by concentrations of 16 to 64 micrograms/ml and killed by 64 to greater than or equal to 128 micrograms/ml. Staphylococcal killing was consistently greater in the presence of cations and was unaffected by methicillin resistance.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bernard E. M., Donnelly H. J., Maher M. P., Armstrong D. Use of a new bioassay to study pentamidine pharmacokinetics. J Infect Dis. 1985 Oct;152(4):750–754. doi: 10.1093/infdis/152.4.750. [DOI] [PubMed] [Google Scholar]
- Bichowsky-Slomnitzki L. The Effect of Aromatic Diamidines on Bacterial Growth: I. The Mechanism of Action. J Bacteriol. 1948 Jan;55(1):27–31. [PMC free article] [PubMed] [Google Scholar]
- Bichowsky-Slomnitzki L. The Effect of Aromatic Diamidines on Bacterial Growth: II. The Antagonism of Nucleic Acids and Polyamines. J Bacteriol. 1948 Jan;55(1):33–41. [PMC free article] [PubMed] [Google Scholar]
- Conte J. E., Jr, Upton R. A., Phelps R. T., Wofsy C. B., Zurlinden E., Lin E. T. Use of a specific and sensitive assay to determine pentamidine pharmacokinetics in patients with AIDS. J Infect Dis. 1986 Dec;154(6):923–929. doi: 10.1093/infdis/154.6.923. [DOI] [PubMed] [Google Scholar]
- De N. C., Alam A. S., Kapoor J. N. Stability of pentamidine isethionate in 5% dextrose and 0.9% sodium chloride injections. Am J Hosp Pharm. 1986 Jun;43(6):1486–1488. [PubMed] [Google Scholar]
- Gale E. F., Folkes J. P. Actions of pentamidine on the metabolism of Staphylococcus aureus. Biochim Biophys Acta. 1967 Oct 2;144(2):467–470. doi: 10.1016/0005-2760(67)90178-6. [DOI] [PubMed] [Google Scholar]
- HICKS R. M. The effect of isoniazid, carbutamide, propamidine and pentamidine on the transminases and growth of Escherichia coli, strain 15, mutant M2. Biochim Biophys Acta. 1961 Jan 1;46:143–151. doi: 10.1016/0006-3002(61)90657-6. [DOI] [PubMed] [Google Scholar]
- Kim S. H., Hong S. S., Alfieri A. A., Kim J. H. Interaction of hyperthermia and pentamidine in HeLa S-3 cells. Radiat Res. 1988 Nov;116(2):320–326. [PubMed] [Google Scholar]
- Kohn H. I. THE EFFECT OF PROPAMIDINE ON BACTERIAL GROWTH. Science. 1943 Sep 3;98(2540):224–224. doi: 10.1126/science.98.2540.224. [DOI] [PubMed] [Google Scholar]
- Sands M., Kron M. A., Brown R. B. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625–634. doi: 10.1093/clinids/7.5.625. [DOI] [PubMed] [Google Scholar]