Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1990 Sep;34(9):1821–1823. doi: 10.1128/aac.34.9.1821

Ampicillin-resistant enterococcal species in an acute-care hospital.

S E Oster 1, V A Chirurgi 1, A A Goldberg 1, S Aiken 1, R E McCabe 1
PMCID: PMC171938  PMID: 2285299

Abstract

A prospective review of all enterococcal isolates for 13 months showed that 9.0% were resistant to ampicillin (MIC, greater than or equal to 16 micrograms/ml; zone diameter, less than 15 mm), as determined by the Vitek system, disk diffusion, microdilution MIC testing, and macrodilution MIC testing. All were beta-lactamase negative. A total of 19 and 3 resistant isolates were from urine and intravascular sites, respectively. Ampicillin-resistant enterococci appear to be a growing clinical problem.

Full text

PDF
1822

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bush L. M., Calmon J., Cherney C. L., Wendeler M., Pitsakis P., Poupard J., Levison M. E., Johnson C. C. High-level penicillin resistance among isolates of enterococci. Implications for treatment of enterococcal infections. Ann Intern Med. 1989 Apr 1;110(7):515–520. doi: 10.7326/0003-4819-110-7-515. [DOI] [PubMed] [Google Scholar]
  2. Fabbri A., Manno G., Tacchella A., Belli M. L., Palmero C. Susceptibility of enterococci. I. Inhibitory and bactericidal activity of several chemoantibiotics against Streptococcus faecalis and Streptococcus faecium. Chemioterapia. 1986 Oct;5(5):302–308. [PubMed] [Google Scholar]
  3. Facklam R. R., Collins M. D. Identification of Enterococcus species isolated from human infections by a conventional test scheme. J Clin Microbiol. 1989 Apr;27(4):731–734. doi: 10.1128/jcm.27.4.731-734.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fontana R., Grossato A., Rossi L., Cheng Y. R., Satta G. Transition from resistance to hypersusceptibility to beta-lactam antibiotics associated with loss of a low-affinity penicillin-binding protein in a Streptococcus faecium mutant highly resistant to penicillin. Antimicrob Agents Chemother. 1985 Nov;28(5):678–683. doi: 10.1128/aac.28.5.678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kaye D. Enterococci. Biologic and epidemiologic characteristics and in vitro susceptibility. Arch Intern Med. 1982 Oct 25;142(11):2006–2009. doi: 10.1001/archinte.142.11.2006. [DOI] [PubMed] [Google Scholar]
  6. Moellering R. C., Jr Enterococcal infections in patients treated with moxalactam. Rev Infect Dis. 1982 Nov-Dec;4 (Suppl):S708–S711. doi: 10.1093/clinids/4.supplement_3.s708. [DOI] [PubMed] [Google Scholar]
  7. Murray B. E., Church D. A., Wanger A., Zscheck K., Levison M. E., Ingerman M. J., Abrutyn E., Mederski-Samoraj B. Comparison of two beta-lactamase-producing strains of Streptococcus faecalis. Antimicrob Agents Chemother. 1986 Dec;30(6):861–864. doi: 10.1128/aac.30.6.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Murray B. E., Mederski-Samoraj B., Foster S. K., Brunton J. L., Harford P. In vitro studies of plasmid-mediated penicillinase from Streptococcus faecalis suggest a staphylococcal origin. J Clin Invest. 1986 Jan;77(1):289–293. doi: 10.1172/JCI112289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Patterson J. E., Masecar B. L., Zervos M. J. Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis. Antimicrob Agents Chemother. 1988 Jan;32(1):122–124. doi: 10.1128/aac.32.1.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ruoff K. L., de la Maza L., Murtagh M. J., Spargo J. D., Ferraro M. J. Species identities of enterococci isolated from clinical specimens. J Clin Microbiol. 1990 Mar;28(3):435–437. doi: 10.1128/jcm.28.3.435-437.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sapico F. L., Canawati H. N., Ginunas V. J., Gilmore D. S., Montgomerie J. Z., Tuddenham W. J., Facklam R. R. Enterococci highly resistant to penicillin and ampicillin: an emerging clinical problem? J Clin Microbiol. 1989 Sep;27(9):2091–2095. doi: 10.1128/jcm.27.9.2091-2095.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tofte R. W., Solliday J. A., Crossley K. B. Susceptibilities of enterococci to twelve antibiotics. Antimicrob Agents Chemother. 1984 Apr;25(4):532–533. doi: 10.1128/aac.25.4.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Williamson R., le Bouguénec C., Gutmann L., Horaud T. One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin. J Gen Microbiol. 1985 Aug;131(8):1933–1940. doi: 10.1099/00221287-131-8-1933. [DOI] [PubMed] [Google Scholar]
  14. Zervos M. J., Patterson J. E., Edberg S., Pierson C., Kauffman C. A., Mikesell T. S., Schaberg D. R. Single-concentration broth microdilution test for detection of high-level aminoglycoside resistance in enterococci. J Clin Microbiol. 1987 Dec;25(12):2443–2444. doi: 10.1128/jcm.25.12.2443-2444.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES