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. 1988 May;32(5):758–760. doi: 10.1128/aac.32.5.758

Animal model for evaluating the convulsive liability of beta-lactam antibiotics.

P D Williams 1, D B Bennett 1, C R Comereski 1
PMCID: PMC172267  PMID: 3395104

Abstract

The beta-lactam antibiotics imipenem-cilastatin, BMY-26225, and cefazolin significantly lowered the convulsive threshold of pentylenetetrazole in mice. In addition, imipenem-cilastatin and cefazolin were found to inhibit 3H-labeled gamma-aminobutyric acid binding to synaptic membranes from rat brains. Our results suggest that the pentylenetetrazole convulsive model may be useful in evaluating the proconvulsive liabilities of new carbapenems and other beta-lactam antibiotics and that the mechanism of imipenem-cilastatin and cefazolin toxicity may involve interaction with gamma-aminobutyric acid receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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