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. 1988 Jul;32(7):1100–1102. doi: 10.1128/aac.32.7.1100

Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.

A Karlsson 1, J Harmenberg 1
PMCID: PMC172354  PMID: 2847642

Abstract

The pyrimidine metabolism of fibroblasts infected with herpes simplex virus type 1 was studied. Herpes simplex virus type 1 infection increased the dTTP pool and thymidylate synthetase activity but reduced thymidine excretion. Addition of acyclovir to infected cells increased thymidine excretion, the dTTP pool, and thymidylate synthetase activity. Addition of a virus-specific ribonucleotide reductase inhibitor (A723U) decreased all three. The synergy between the two compounds is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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