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. 1997 Oct;10(4):720–741. doi: 10.1128/cmr.10.4.720

Helicobacter pylori.

B E Dunn 1, H Cohen 1, M J Blaser 1
PMCID: PMC172942  PMID: 9336670

Abstract

Helicobacter pylori is a gram-negative bacterium which causes chronic gastritis and plays important roles in peptic ulcer disease, gastric carcinoma, and gastric lymphoma. H. pylori has been found in the stomachs of humans in all parts of the world. In developing countries, 70 to 90% of the population carries H. pylori. In developed countries, the prevalence of infection is lower. There appears to be no substantial reservoir of H. pylori aside from the human stomach. Transmission can occur by iatrogenic, fecal-oral, and oral-oral routes. H. pylori is able to colonize and persist in a unique biological niche within the gastric lumen. All fresh isolates of H. pylori express significant urease activity, which appears essential to the survival and pathogenesis of the bacterium. A variety of tests to diagnose H. pylori infection are now available. Histological examination of gastric tissue, culture, rapid urease testing, DNA probes, and PCR analysis, when used to test gastric tissue, all require endoscopy. In contrast, breath tests, serology, gastric juice PCR, and urinary excretion of [15N]ammonia are noninvasive tests that do not require endoscopy. In this review, we highlight advances in the detection of the presence of the organism and methods of differentiating among types of H. pylori, and we provide a background for appropriate chemotherapy of the infection.

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Selected References

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  1. Akamatsu T., Tabata K., Hironga M., Kawakami H., Uyeda M. Transmission of Helicobacter pylori infection via flexible fiberoptic endoscopy. Am J Infect Control. 1996 Oct;24(5):396–401. doi: 10.1016/s0196-6553(96)90028-0. [DOI] [PubMed] [Google Scholar]
  2. Alemohammad M. M., Foley T. J., Cohen H. Detection of immunoglobulin G antibodies to Helicobacter pylori in urine by an enzyme immunoassay method. J Clin Microbiol. 1993 Aug;31(8):2174–2177. doi: 10.1128/jcm.31.8.2174-2177.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Andersen L. P., Espersen F. Immunoglobulin G antibodies to Helicobacter pylori in patients with dyspeptic symptoms investigated by the western immunoblot technique. J Clin Microbiol. 1992 Jul;30(7):1743–1751. doi: 10.1128/jcm.30.7.1743-1751.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Andersen L. P., Nørgaard A., Holck S., Blom J., Elsborg L. Isolation of a "Helicobacter heilmanii"-like organism from the human stomach. Eur J Clin Microbiol Infect Dis. 1996 Jan;15(1):95–96. doi: 10.1007/BF01586196. [DOI] [PubMed] [Google Scholar]
  5. Andrew A., Wyatt J. I., Dixon M. F. Observer variation in the assessment of chronic gastritis according to the Sydney system. Histopathology. 1994 Oct;25(4):317–322. doi: 10.1111/j.1365-2559.1994.tb01349.x. [DOI] [PubMed] [Google Scholar]
  6. Andrutis K. A., Fox J. G., Schauer D. B., Marini R. P., Murphy J. C., Yan L., Solnick J. V. Inability of an isogenic urease-negative mutant stain of Helicobacter mustelae to colonize the ferret stomach. Infect Immun. 1995 Sep;63(9):3722–3725. doi: 10.1128/iai.63.9.3722-3725.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ansorg R., von Recklinghausen G., Heintschel von Heinegg E. Susceptibility of Helicobacter pylori to simethicone and other non-antibiotic drugs. J Antimicrob Chemother. 1996 Jan;37(1):45–52. doi: 10.1093/jac/37.1.45. [DOI] [PubMed] [Google Scholar]
  8. Appelmelk B. J., Simoons-Smit I., Negrini R., Moran A. P., Aspinall G. O., Forte J. G., De Vries T., Quan H., Verboom T., Maaskant J. J. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect Immun. 1996 Jun;64(6):2031–2040. doi: 10.1128/iai.64.6.2031-2040.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ascencio F., Fransson L. A., Wadström T. Affinity of the gastric pathogen Helicobacter pylori for the N-sulphated glycosaminoglycan heparan sulphate. J Med Microbiol. 1993 Apr;38(4):240–244. doi: 10.1099/00222615-38-4-240. [DOI] [PubMed] [Google Scholar]
  10. Ashton-Key M., Diss T. C., Isaacson P. G. Detection of Helicobacter pylori in gastric biopsy and resection specimens. J Clin Pathol. 1996 Feb;49(2):107–111. doi: 10.1136/jcp.49.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Aspinall G. O., Monteiro M. A. Lipopolysaccharides of Helicobacter pylori strains P466 and MO19: structures of the O antigen and core oligosaccharide regions. Biochemistry. 1996 Feb 20;35(7):2498–2504. doi: 10.1021/bi951853k. [DOI] [PubMed] [Google Scholar]
  12. Aspinall G. O., Monteiro M. A., Pang H., Walsh E. J., Moran A. P. Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): structure of the O antigen chain and core oligosaccharide regions. Biochemistry. 1996 Feb 20;35(7):2489–2497. doi: 10.1021/bi951852s. [DOI] [PubMed] [Google Scholar]
  13. Atherton J. C., Cao P., Peek R. M., Jr, Tummuru M. K., Blaser M. J., Cover T. L. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995 Jul 28;270(30):17771–17777. doi: 10.1074/jbc.270.30.17771. [DOI] [PubMed] [Google Scholar]
  14. Atherton J. C., Peek R. M., Jr, Tham K. T., Cover T. L., Blaser M. J. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology. 1997 Jan;112(1):92–99. doi: 10.1016/s0016-5085(97)70223-3. [DOI] [PubMed] [Google Scholar]
  15. Atherton J. C., Washington N., Blackshaw P. E., Greaves J. L., Perkins A. C., Hawkey C. J., Spiller R. C. Effect of a test meal on the intragastric distribution of urea in the 13C-urea breath test for Helicobacter pylori. Gut. 1995 Mar;36(3):337–340. doi: 10.1136/gut.36.3.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Austin J. W., Doig P., Stewart M., Trust T. J. Structural comparison of urease and a GroEL analog from Helicobacter pylori. J Bacteriol. 1992 Nov;174(22):7470–7473. doi: 10.1128/jb.174.22.7470-7473.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Bagchi D., Bhattacharya G., Stohs S. J. Production of reactive oxygen species by gastric cells in association with Helicobacter pylori. Free Radic Res. 1996 Jun;24(6):439–450. doi: 10.3109/10715769609088043. [DOI] [PubMed] [Google Scholar]
  18. Baik S. C., Youn H. S., Chung M. H., Lee W. K., Cho M. J., Ko G. H., Park C. K., Kasai H., Rhee K. H. Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa. Cancer Res. 1996 Mar 15;56(6):1279–1282. [PubMed] [Google Scholar]
  19. Banatvala N., Mayo K., Megraud F., Jennings R., Deeks J. J., Feldman R. A. The cohort effect and Helicobacter pylori. J Infect Dis. 1993 Jul;168(1):219–221. doi: 10.1093/infdis/168.1.219. [DOI] [PubMed] [Google Scholar]
  20. Bauerfeind P., Garner R. M., Mobley L. T. Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity. Infect Immun. 1996 Jul;64(7):2877–2880. doi: 10.1128/iai.64.7.2877-2880.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Bayerdörffer E., Neubauer A., Rudolph B., Thiede C., Lehn N., Eidt S., Stolte M. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group. Lancet. 1995 Jun 24;345(8965):1591–1594. doi: 10.1016/s0140-6736(95)90113-2. [DOI] [PubMed] [Google Scholar]
  22. Bayerdörffer E., Ritter M. M., Hatz R., Brooks W., Ruckdeschel G., Stolte M. Healing of protein losing hypertrophic gastropathy by eradication of Helicobacter pylori--is Helicobacter pylori a pathogenic factor in Ménétrier's disease? Gut. 1994 May;35(5):701–704. doi: 10.1136/gut.35.5.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Benaissa M., Babin P., Quellard N., Pezennec L., Cenatiempo Y., Fauchère J. L. Changes in Helicobacter pylori ultrastructure and antigens during conversion from the bacillary to the coccoid form. Infect Immun. 1996 Jun;64(6):2331–2335. doi: 10.1128/iai.64.6.2331-2335.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Blaser M. J. Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology. 1987 Aug;93(2):371–383. doi: 10.1016/0016-5085(87)91028-6. [DOI] [PubMed] [Google Scholar]
  25. Blaser M. J. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. J Infect Dis. 1990 Apr;161(4):626–633. doi: 10.1093/infdis/161.4.626. [DOI] [PubMed] [Google Scholar]
  26. Blaser M. J. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992 Feb;102(2):720–727. doi: 10.1016/0016-5085(92)90126-j. [DOI] [PubMed] [Google Scholar]
  27. Blaser M. J. Not all Helicobacter pylori strains are created equal: should all be eliminated? Lancet. 1997 Apr 5;349(9057):1020–1022. doi: 10.1016/S0140-6736(96)09133-7. [DOI] [PubMed] [Google Scholar]
  28. Blaser M. J., Parsonnet J. Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest. 1994 Jul;94(1):4–8. doi: 10.1172/JCI117336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Blaser M. J., Perez-Perez G. I., Kleanthous H., Cover T. L., Peek R. M., Chyou P. H., Stemmermann G. N., Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995 May 15;55(10):2111–2115. [PubMed] [Google Scholar]
  30. Blaser M. J. Role of vacA and the cagA locus of Helicobacter pylori in human disease. Aliment Pharmacol Ther. 1996 Apr;10 (Suppl 1):73–77. doi: 10.1046/j.1365-2036.1996.22164008.x. [DOI] [PubMed] [Google Scholar]
  31. Bode G., Malfertheiner P., Lehnhardt G., Nilius M., Ditschuneit H. Ultrastructural localization of urease of Helicobacter pylori. Med Microbiol Immunol. 1993 Nov;182(5):233–242. doi: 10.1007/BF00579622. [DOI] [PubMed] [Google Scholar]
  32. Bode G., Mauch F., Ditschuneit H., Malfertheiner P. Identification of structures containing polyphosphate in Helicobacter pylori. J Gen Microbiol. 1993 Dec;139(12):3029–3033. doi: 10.1099/00221287-139-12-3029. [DOI] [PubMed] [Google Scholar]
  33. Bode G., Mauch F., Malfertheiner P. The coccoid forms of Helicobacter pylori. Criteria for their viability. Epidemiol Infect. 1993 Dec;111(3):483–490. doi: 10.1017/s0950268800057216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Borody T. J., Andrews P., Fracchia G., Brandl S., Shortis N. P., Bae H. Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori. Gut. 1995 Oct;37(4):477–481. doi: 10.1136/gut.37.4.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Borén T., Falk P., Roth K. A., Larson G., Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science. 1993 Dec 17;262(5141):1892–1895. doi: 10.1126/science.8018146. [DOI] [PubMed] [Google Scholar]
  36. Bottomley J. R., Clayton C. L., Chalk P. A., Kleanthous C. Cloning, sequencing, expression, purification and preliminary characterization of a type II dehydroquinase from Helicobacter pylori. Biochem J. 1996 Oct 15;319(Pt 2):559–565. doi: 10.1042/bj3190559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Bukanov N. O., Berg D. E. Ordered cosmid library and high-resolution physical-genetic map of Helicobacter pylori strain NCTC11638. Mol Microbiol. 1994 Feb;11(3):509–523. doi: 10.1111/j.1365-2958.1994.tb00332.x. [DOI] [PubMed] [Google Scholar]
  38. Burns B. P., Hazell S. L., Mendz G. L. Acetyl-CoA carboxylase activity in Helicobacter pylori and the requirement of increased CO2 for growth. Microbiology. 1995 Dec;141(Pt 12):3113–3118. doi: 10.1099/13500872-141-12-3113. [DOI] [PubMed] [Google Scholar]
  39. Béji A., Mégraud F., Vincent P., Gavini F., Izard D., Leclerc H. GC content of DNA of Campylobacter pylori and other species belonging or related to the genus Campylobacter. Ann Inst Pasteur Microbiol. 1988 Sep-Oct;139(5):527–534. doi: 10.1016/0769-2609(88)90152-4. [DOI] [PubMed] [Google Scholar]
  40. Calam J. Helicobacter pylori, acid and gastrin. Eur J Gastroenterol Hepatol. 1995 Apr;7(4):310–317. [PubMed] [Google Scholar]
  41. Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet. 1984 Jun 16;1(8390):1348–1349. [PubMed] [Google Scholar]
  42. Caselli M., Aleotti A., Boldrini P., Ruina M., Alvisi V. Ultrastructural patterns of Helicobacter pylori. Gut. 1993 Nov;34(11):1507–1509. doi: 10.1136/gut.34.11.1507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Cellini L. Coccoid forms of Helicobacter pylori. J Infect Dis. 1996 May;173(5):1288–1289. doi: 10.1093/infdis/173.5.1288. [DOI] [PubMed] [Google Scholar]
  44. Censini S., Lange C., Xiang Z., Crabtree J. E., Ghiara P., Borodovsky M., Rappuoli R., Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14648–14653. doi: 10.1073/pnas.93.25.14648. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Chan W. Y., Hui P. K., Leung K. M., Chow J., Kwok F., Ng C. S. Coccoid forms of Helicobacter pylori in the human stomach. Am J Clin Pathol. 1994 Oct;102(4):503–507. doi: 10.1093/ajcp/102.4.503. [DOI] [PubMed] [Google Scholar]
  46. Chen M., Lee A., Hazell S. Immunisation against gastric helicobacter infection in a mouse/Helicobacter felis model. Lancet. 1992 May 2;339(8801):1120–1121. doi: 10.1016/0140-6736(92)90720-n. [DOI] [PubMed] [Google Scholar]
  47. Chen T. S., Tsay S. H., Chang F. Y., Lee S. D. Effect of eradication of Helicobacter pylori on serum pepsinogen I, gastrin, and insulin in duodenal ulcer patients: a 12-month follow-up study. Am J Gastroenterol. 1994 Sep;89(9):1511–1514. [PubMed] [Google Scholar]
  48. Chong S. K., Lou Q., Fitzgerald J. F., Lee C. H. Evaluation of 16S rRNA gene PCR with primers Hp1 and Hp2 for detection of Helicobacter pylori. J Clin Microbiol. 1996 Nov;34(11):2728–2730. doi: 10.1128/jcm.34.11.2728-2730.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Christensen A. H., Gjørup T., Hilden J., Fenger C., Henriksen B., Vyberg M., Ostergaard K., Hansen B. F. Observer homogeneity in the histologic diagnosis of Helicobacter pylori. Latent class analysis, kappa coefficient, and repeat frequency. Scand J Gastroenterol. 1992 Nov;27(11):933–939. doi: 10.3109/00365529209000166. [DOI] [PubMed] [Google Scholar]
  50. Clyne M., Drumm B. Adherence of Helicobacter pylori to primary human gastrointestinal cells. Infect Immun. 1993 Oct;61(10):4051–4057. doi: 10.1128/iai.61.10.4051-4057.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Collins J. S., Hamilton P. W., Watt P. C., Sloan J. M., Love A. H. Superficial gastritis and Campylobacter pylori in dyspeptic patients--a quantitative study using computer-linked image analysis. J Pathol. 1989 Aug;158(4):303–310. doi: 10.1002/path.1711580407. [DOI] [PubMed] [Google Scholar]
  52. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992 Dec 15;52(24):6735–6740. [PubMed] [Google Scholar]
  53. Corthésy-Theulaz I., Porta N., Glauser M., Saraga E., Vaney A. C., Haas R., Kraehenbuhl J. P., Blum A. L., Michetti P. Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice. Gastroenterology. 1995 Jul;109(1):115–121. doi: 10.1016/0016-5085(95)90275-9. [DOI] [PubMed] [Google Scholar]
  54. Coudron P. E., Stratton C. W. Factors affecting growth and susceptibility testing of Helicobacter pylori in liquid media. J Clin Microbiol. 1995 Apr;33(4):1028–1030. doi: 10.1128/jcm.33.4.1028-1030.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Coudron P. E., Stratton C. W. Use of time-kill methodology to assess antimicrobial combinations against metronidazole-susceptible and metronidazole-resistant strains of Helicobacter pylori. Antimicrob Agents Chemother. 1995 Dec;39(12):2641–2644. doi: 10.1128/aac.39.12.2641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Covacci A., Censini S., Bugnoli M., Petracca R., Burroni D., Macchia G., Massone A., Papini E., Xiang Z., Figura N. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791–5795. doi: 10.1073/pnas.90.12.5791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Cover T. L., Blaser M. J. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem. 1992 May 25;267(15):10570–10575. [PubMed] [Google Scholar]
  58. Cover T. L., Cao P., Murthy U. K., Sipple M. S., Blaser M. J. Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori. J Clin Invest. 1992 Sep;90(3):913–918. doi: 10.1172/JCI115967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Cover T. L., Glupczynski Y., Lage A. P., Burette A., Tummuru M. K., Perez-Perez G. I., Blaser M. J. Serologic detection of infection with cagA+ Helicobacter pylori strains. J Clin Microbiol. 1995 Jun;33(6):1496–1500. doi: 10.1128/jcm.33.6.1496-1500.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Cover T. L., Halter S. A., Blaser M. J. Characterization of HeLa cell vacuoles induced by Helicobacter pylori broth culture supernatant. Hum Pathol. 1992 Sep;23(9):1004–1010. doi: 10.1016/0046-8177(92)90261-z. [DOI] [PubMed] [Google Scholar]
  61. Cover T. L., Puryear W., Perez-Perez G. I., Blaser M. J. Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin. Infect Immun. 1991 Apr;59(4):1264–1270. doi: 10.1128/iai.59.4.1264-1270.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Cover T. L., Reddy L. Y., Blaser M. J. Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin. Infect Immun. 1993 Apr;61(4):1427–1431. doi: 10.1128/iai.61.4.1427-1431.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Cover T. L., Tummuru M. K., Cao P., Thompson S. A., Blaser M. J. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem. 1994 Apr 8;269(14):10566–10573. [PubMed] [Google Scholar]
  64. Crabtree J. E., Covacci A., Farmery S. M., Xiang Z., Tompkins D. S., Perry S., Lindley I. J., Rappuoli R. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol. 1995 Jan;48(1):41–45. doi: 10.1136/jcp.48.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Cutler A. F., Havstad S., Ma C. K., Blaser M. J., Perez-Perez G. I., Schubert T. T. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology. 1995 Jul;109(1):136–141. doi: 10.1016/0016-5085(95)90278-3. [DOI] [PubMed] [Google Scholar]
  66. Cutler A., Schubert A., Schubert T. Role of Helicobacter pylori serology in evaluating treatment success. Dig Dis Sci. 1993 Dec;38(12):2262–2266. doi: 10.1007/BF01299906. [DOI] [PubMed] [Google Scholar]
  67. Czinn S. J., Cai A., Nedrud J. G. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine. 1993;11(6):637–642. doi: 10.1016/0264-410x(93)90309-l. [DOI] [PubMed] [Google Scholar]
  68. Davies G. R., Banatvala N., Collins C. E., Sheaff M. T., Abdi Y., Clements L., Rampton D. S. Relationship between infective load of Helicobacter pylori and reactive oxygen metabolite production in antral mucosa. Scand J Gastroenterol. 1994 May;29(5):419–424. doi: 10.3109/00365529409096832. [DOI] [PubMed] [Google Scholar]
  69. Davies G. R., Simmonds N. J., Stevens T. R., Sheaff M. T., Banatvala N., Laurenson I. F., Blake D. R., Rampton D. S. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut. 1994 Feb;35(2):179–185. doi: 10.1136/gut.35.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. De Boer W. A., Driessen W. M., Tytgat G. N. Only four days of quadruple therapy can effectively cure Helicobacter pylori infection. Aliment Pharmacol Ther. 1995 Dec;9(6):633–638. doi: 10.1111/j.1365-2036.1995.tb00432.x. [DOI] [PubMed] [Google Scholar]
  71. Debets-Ossenkopp Y. J., Sparrius M., Kusters J. G., Kolkman J. J., Vandenbroucke-Grauls C. M. Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori. FEMS Microbiol Lett. 1996 Aug 15;142(1):37–42. doi: 10.1111/j.1574-6968.1996.tb08404.x. [DOI] [PubMed] [Google Scholar]
  72. Debongnie J. C., Donnay M., Mairesse J. Gastrospirillum hominis ("Helicobacter heilmanii"): a cause of gastritis, sometimes transient, better diagnosed by touch cytology? Am J Gastroenterol. 1995 Mar;90(3):411–416. [PubMed] [Google Scholar]
  73. Desai M., Linton D., Owen R. J., Stanley J. Molecular typing of Helicobacter pylori isolates from asymptomatic, ulcer and gastritis patients by urease gene polymorphism. Epidemiol Infect. 1994 Feb;112(1):151–160. doi: 10.1017/s0950268800057514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Dickey W., Kenny B. D., McConnell J. B. Effect of proton pump inhibitors on the detection of Helicobacter pylori in gastric biopsies. Aliment Pharmacol Ther. 1996 Jun;10(3):289–293. doi: 10.1111/j.0953-0673.1996.00289.x. [DOI] [PubMed] [Google Scholar]
  75. Dixon M. F., Genta R. M., Yardley J. H., Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996 Oct;20(10):1161–1181. doi: 10.1097/00000478-199610000-00001. [DOI] [PubMed] [Google Scholar]
  76. Dixon M. F. Histological responses to Helicobacter pylori infection: gastritis, atrophy and preneoplasia. Baillieres Clin Gastroenterol. 1995 Sep;9(3):467–486. doi: 10.1016/0950-3528(95)90043-8. [DOI] [PubMed] [Google Scholar]
  77. Doidge C., Crust I., Lee A., Buck F., Hazell S., Manne U. Therapeutic immunisation against Helicobacter infection. Lancet. 1994 Apr 9;343(8902):914–915. doi: 10.1016/s0140-6736(94)90032-9. [DOI] [PubMed] [Google Scholar]
  78. Doig P., Exner M. M., Hancock R. E., Trust T. J. Isolation and characterization of a conserved porin protein from Helicobacter pylori. J Bacteriol. 1995 Oct;177(19):5447–5452. doi: 10.1128/jb.177.19.5447-5452.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Doig P., Trust T. J. Identification of surface-exposed outer membrane antigens of Helicobacter pylori. Infect Immun. 1994 Oct;62(10):4526–4533. doi: 10.1128/iai.62.10.4526-4533.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Drake I. M., Davies M. J., Mapstone N. P., Dixon M. F., Schorah C. J., White K. L., Chalmers D. M., Axon A. T. Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals. Carcinogenesis. 1996 Mar;17(3):559–562. doi: 10.1093/carcin/17.3.559. [DOI] [PubMed] [Google Scholar]
  81. Drouet E. B., De Montclos H. P., Andujar M., Boude M., Grimaud J. A., Denoyel G. A. Partial characterization of an external polysaccharide of Helicobacter pylori by using an immunoglobulin M monoclonal antibody. Infect Immun. 1993 Jun;61(6):2732–2736. doi: 10.1128/iai.61.6.2732-2736.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Dubois A., Fiala N., Heman-Ackah L. M., Drazek E. S., Tarnawski A., Fishbein W. N., Perez-Perez G. I., Blaser M. J. Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology. 1994 Jun;106(6):1405–1417. doi: 10.1016/0016-5085(94)90392-1. [DOI] [PubMed] [Google Scholar]
  83. Dunn B. E., Campbell G. P., Perez-Perez G. I., Blaser M. J. Purification and characterization of urease from Helicobacter pylori. J Biol Chem. 1990 Jun 5;265(16):9464–9469. [PubMed] [Google Scholar]
  84. Dunn B. E., Perez-Perez G. I., Blaser M. J. Two-dimensional gel electrophoresis and immunoblotting of Campylobacter pylori proteins. Infect Immun. 1989 Jun;57(6):1825–1833. doi: 10.1128/iai.57.6.1825-1833.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Dunn B. E., Roop R. M., 2nd, Sung C. C., Sharma S. A., Perez-Perez G. I., Blaser M. J. Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori. Infect Immun. 1992 May;60(5):1946–1951. doi: 10.1128/iai.60.5.1946-1951.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  86. Dunn B. E., Sung C. C., Taylor N. S., Fox J. G. Purification and characterization of Helicobacter mustelae urease. Infect Immun. 1991 Sep;59(9):3343–3345. doi: 10.1128/iai.59.9.3343-3345.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Dunn B. E., Vakil N. B., Schneider B. G., Miller M. M., Zitzer J. B., Peutz T., Phadnis S. H. Localization of Helicobacter pylori urease and heat shock protein in human gastric biopsies. Infect Immun. 1997 Apr;65(4):1181–1188. doi: 10.1128/iai.65.4.1181-1188.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Eaton K. A., Brooks C. L., Morgan D. R., Krakowka S. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun. 1991 Jul;59(7):2470–2475. doi: 10.1128/iai.59.7.2470-2475.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Eaton K. A., Catrenich C. E., Makin K. M., Krakowka S. Virulence of coccoid and bacillary forms of Helicobacter pylori in gnotobiotic piglets. J Infect Dis. 1995 Feb;171(2):459–462. doi: 10.1093/infdis/171.2.459. [DOI] [PubMed] [Google Scholar]
  90. Eaton K. A., Krakowka S. Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori. Infect Immun. 1994 Sep;62(9):3604–3607. doi: 10.1128/iai.62.9.3604-3607.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Eaton K. A., Morgan D. R., Krakowka S. Campylobacter pylori virulence factors in gnotobiotic piglets. Infect Immun. 1989 Apr;57(4):1119–1125. doi: 10.1128/iai.57.4.1119-1125.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Eaton K. A., Morgan D. R., Krakowka S. Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori. J Med Microbiol. 1992 Aug;37(2):123–127. doi: 10.1099/00222615-37-2-123. [DOI] [PubMed] [Google Scholar]
  93. Eaton K. A., Suerbaum S., Josenhans C., Krakowka S. Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes. Infect Immun. 1996 Jul;64(7):2445–2448. doi: 10.1128/iai.64.7.2445-2448.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Eidt S., Stolte M., Fischer R. Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas. J Clin Pathol. 1994 May;47(5):436–439. doi: 10.1136/jcp.47.5.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Eschweiler B., Bohrmann B., Gerstenecker B., Schiltz E., Kist M. In situ localization of the 60 k protein of Helicobacter pylori, which belongs to the family of heat shock proteins, by immuno-electron microscopy. Zentralbl Bakteriol. 1993 Sep;280(1-2):73–85. doi: 10.1016/s0934-8840(11)80942-4. [DOI] [PubMed] [Google Scholar]
  96. Evans D. G., Karjalainen T. K., Evans D. J., Jr, Graham D. Y., Lee C. H. Cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of Helicobacter pylori. J Bacteriol. 1993 Feb;175(3):674–683. doi: 10.1128/jb.175.3.674-683.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Evans D. J., Jr, Evans D. G., Engstrand L., Graham D. Y. Urease-associated heat shock protein of Helicobacter pylori. Infect Immun. 1992 May;60(5):2125–2127. doi: 10.1128/iai.60.5.2125-2127.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Evans D. J., Jr, Evans D. G., Graham D. Y., Klein P. D. A sensitive and specific serologic test for detection of Campylobacter pylori infection. Gastroenterology. 1989 Apr;96(4):1004–1008. doi: 10.1016/0016-5085(89)91616-8. [DOI] [PubMed] [Google Scholar]
  99. Evans D. J., Jr, Evans D. G., Takemura T., Nakano H., Lampert H. C., Graham D. Y., Granger D. N., Kvietys P. R. Characterization of a Helicobacter pylori neutrophil-activating protein. Infect Immun. 1995 Jun;63(6):2213–2220. doi: 10.1128/iai.63.6.2213-2220.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Exner M. M., Doig P., Trust T. J., Hancock R. E. Isolation and characterization of a family of porin proteins from Helicobacter pylori. Infect Immun. 1995 Apr;63(4):1567–1572. doi: 10.1128/iai.63.4.1567-1572.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Fabry W., Okemo P., Ansorg R. Activity of east African medicinal plants against Helicobacter pylori. Chemotherapy. 1996 Sep-Oct;42(5):315–317. doi: 10.1159/000239460. [DOI] [PubMed] [Google Scholar]
  102. Falk P., Roth K. A., Borén T., Westblom T. U., Gordon J. I., Normark S. An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2035–2039. doi: 10.1073/pnas.90.5.2035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Fallone C. A., Elizov M., Cleland P., Thompson J. A., Wild G. E., Lough J., Faria J., Barkun A. N. Detection of Helicobacter pylori infection by saliva IgG testing. Am J Gastroenterol. 1996 Jun;91(6):1145–1149. [PubMed] [Google Scholar]
  104. Fan X. G., Chua A., Fan X. J., Keeling P. W. Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection. J Clin Pathol. 1995 Feb;48(2):133–136. doi: 10.1136/jcp.48.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Ferrero R. L., Thiberge J. M., Huerre M., Labigne A. Recombinant antigens prepared from the urease subunits of Helicobacter spp.: evidence of protection in a mouse model of gastric infection. Infect Immun. 1994 Nov;62(11):4981–4989. doi: 10.1128/iai.62.11.4981-4989.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Ferrero R. L., Thiberge J. M., Kansau I., Wuscher N., Huerre M., Labigne A. The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6499–6503. doi: 10.1073/pnas.92.14.6499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  107. Fiedorek S. C., Malaty H. M., Evans D. L., Pumphrey C. L., Casteel H. B., Evans D. J., Jr, Graham D. Y. Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics. 1991 Sep;88(3):578–582. [PubMed] [Google Scholar]
  108. Forbes K. J., Fang Z., Pennington T. H. Allelic variation in the Helicobacter pylori flagellin genes flaA and flaB: its consequences for strain typing schemes and population structure. Epidemiol Infect. 1995 Apr;114(2):257–266. doi: 10.1017/s0950268800057927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Forman D., Newell D. G., Fullerton F., Yarnell J. W., Stacey A. R., Wald N., Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991 Jun 1;302(6788):1302–1305. doi: 10.1136/bmj.302.6788.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Fox J. G., Batchelder M., Marini R., Yan L., Handt L., Li X., Shames B., Hayward A., Campbell J., Murphy J. C. Helicobacter pylori-induced gastritis in the domestic cat. Infect Immun. 1995 Jul;63(7):2674–2681. doi: 10.1128/iai.63.7.2674-2681.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Foxall P. A., Hu L. T., Mobley H. L. Use of polymerase chain reaction-amplified Helicobacter pylori urease structural genes for differentiation of isolates. J Clin Microbiol. 1992 Mar;30(3):739–741. doi: 10.1128/jcm.30.3.739-741.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Garner J. A., Cover T. L. Analysis of genetic diversity in cytotoxin-producing and non-cytotoxin-producing Helicobacter pylori strains. J Infect Dis. 1995 Jul;172(1):290–293. doi: 10.1093/infdis/172.1.290. [DOI] [PubMed] [Google Scholar]
  113. Ge Z., Hiratsuka K., Taylor D. E. Nucleotide sequence and mutational analysis indicate that two Helicobacter pylori genes encode a P-type ATPase and a cation-binding protein associated with copper transport. Mol Microbiol. 1995 Jan;15(1):97–106. doi: 10.1111/j.1365-2958.1995.tb02224.x. [DOI] [PubMed] [Google Scholar]
  114. Geis G., Suerbaum S., Forsthoff B., Leying H., Opferkuch W. Ultrastructure and biochemical studies of the flagellar sheath of Helicobacter pylori. J Med Microbiol. 1993 May;38(5):371–377. doi: 10.1099/00222615-38-5-371. [DOI] [PubMed] [Google Scholar]
  115. Geller S. A. Small organism, many challenges. Hum Pathol. 1996 Jan;27(1):1–4. doi: 10.1016/s0046-8177(96)90129-x. [DOI] [PubMed] [Google Scholar]
  116. Genta R. M., Graham D. Y. Comparison of biopsy sites for the histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distribution. Gastrointest Endosc. 1994 May-Jun;40(3):342–345. doi: 10.1016/s0016-5107(94)70067-2. [DOI] [PubMed] [Google Scholar]
  117. Genta R. M., Graham D. Y. Helicobacter pylori: the new bug on the (paraffin) block. Virchows Arch. 1994;425(4):339–347. doi: 10.1007/BF00189571. [DOI] [PubMed] [Google Scholar]
  118. Genta R. M., Gürer I. E., Graham D. Y., Krishnan B., Segura A. M., Gutierrez O., Kim J. G., Burchette J. L., Jr Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa. Gastroenterology. 1996 Nov;111(5):1206–1211. doi: 10.1053/gast.1996.v111.pm8898634. [DOI] [PubMed] [Google Scholar]
  119. Genta R. M., Hamner H. W., Graham D. Y. Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum Pathol. 1993 Jun;24(6):577–583. doi: 10.1016/0046-8177(93)90235-9. [DOI] [PubMed] [Google Scholar]
  120. Genta R. M., Robason G. O., Graham D. Y. Simultaneous visualization of Helicobacter pylori and gastric morphology: a new stain. Hum Pathol. 1994 Mar;25(3):221–226. doi: 10.1016/0046-8177(94)90191-0. [DOI] [PubMed] [Google Scholar]
  121. Glupczynski Y., Burette A., De Koster E., Nyst J. F., Deltenre M., Cadranel S., Bourdeaux L., De Vos D. Metronidazole resistance in Helicobacter pylori. Lancet. 1990 Apr 21;335(8695):976–977. doi: 10.1016/0140-6736(90)91043-a. [DOI] [PubMed] [Google Scholar]
  122. Go M. F., Kapur V., Graham D. Y., Musser J. M. Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure. J Bacteriol. 1996 Jul;178(13):3934–3938. doi: 10.1128/jb.178.13.3934-3938.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Gold B. D., Huesca M., Sherman P. M., Lingwood C. A. Helicobacter mustelae and Helicobacter pylori bind to common lipid receptors in vitro. Infect Immun. 1993 Jun;61(6):2632–2638. doi: 10.1128/iai.61.6.2632-2638.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. Goodwin C. S., Armstrong J. A. Microbiological aspects of Helicobacter pylori (Campylobacter pylori). Eur J Clin Microbiol Infect Dis. 1990 Jan;9(1):1–13. doi: 10.1007/BF01969526. [DOI] [PubMed] [Google Scholar]
  125. Goodwin C. S., McCulloch R. K., Armstrong J. A., Wee S. H. Unusual cellular fatty acids and distinctive ultrastructure in a new spiral bacterium (Campylobacter pyloridis) from the human gastric mucosa. J Med Microbiol. 1985 Apr;19(2):257–267. doi: 10.1099/00222615-19-2-257. [DOI] [PubMed] [Google Scholar]
  126. Graham D. Y., Malaty H. M., Evans D. G., Evans D. J., Jr, Klein P. D., Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991 Jun;100(6):1495–1501. doi: 10.1016/0016-5085(91)90644-z. [DOI] [PubMed] [Google Scholar]
  127. Graham D. Y., de Boer W. A., Tytgat G. N. Choosing the best anti-Helicobacter pylori therapy: effect of antimicrobial resistance. Am J Gastroenterol. 1996 Jun;91(6):1072–1076. [PubMed] [Google Scholar]
  128. Graham K. S., Malaty H., el-Zimaity H. M., Genta R. M., Cole R. A., al-Assi M. T., Yousfi M. M., Neil G. A., Graham D. Y. Variability with omeprazole-amoxicillin combinations for treatment of Helicobacter pylori infection. Am J Gastroenterol. 1995 Sep;90(9):1415–1418. [PubMed] [Google Scholar]
  129. Hachem C. Y., Clarridge J. E., Evans D. G., Graham D. Y. Comparison of agar based media for primary isolation of Helicobacter pylori. J Clin Pathol. 1995 Aug;48(8):714–716. doi: 10.1136/jcp.48.8.714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Han S. W., Flamm R., Hachem C. Y., Kim H. Y., Clarridge J. E., Evans D. G., Beyer J., Drnec J., Graham D. Y. Transport and storage of Helicobacter pylori from gastric mucosal biopsies and clinical isolates. Eur J Clin Microbiol Infect Dis. 1995 Apr;14(4):349–352. doi: 10.1007/BF02116531. [DOI] [PubMed] [Google Scholar]
  131. Harris P. R., Mobley H. L., Perez-Perez G. I., Blaser M. J., Smith P. D. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology. 1996 Aug;111(2):419–425. doi: 10.1053/gast.1996.v111.pm8690207. [DOI] [PubMed] [Google Scholar]
  132. Hawtin P. R., Stacey A. R., Newell D. G. Investigation of the structure and localization of the urease of Helicobacter pylori using monoclonal antibodies. J Gen Microbiol. 1990 Oct;136(10):1995–2000. doi: 10.1099/00221287-136-10-1995. [DOI] [PubMed] [Google Scholar]
  133. Hazell S. L., Graham D. Y. Unsaturated fatty acids and viability of Helicobacter (Campylobacter) pylori. J Clin Microbiol. 1990 May;28(5):1060–1061. doi: 10.1128/jcm.28.5.1060-1061.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Henriksen T. H., Brorson O., Schöyen R., Thoresen T., Setegn D., Madebo T. Rapid growth of Helicobacter pylori. Eur J Clin Microbiol Infect Dis. 1995 Nov;14(11):1008–1011. doi: 10.1007/BF01691385. [DOI] [PubMed] [Google Scholar]
  135. Hirai M., Azuma T., Ito S., Kato T., Kohli Y., Fujiki N. High prevalence of neutralizing activity to Helicobacter pylori cytotoxin in serum of gastric-carcinoma patients. Int J Cancer. 1994 Jan 2;56(1):56–60. doi: 10.1002/ijc.2910560111. [DOI] [PubMed] [Google Scholar]
  136. Hirmo S., Kelm S., Schauer R., Nilsson B., Wadström T. Adhesion of Helicobacter pylori strains to alpha-2,3-linked sialic acids. Glycoconj J. 1996 Dec;13(6):1005–1011. doi: 10.1007/BF01053196. [DOI] [PubMed] [Google Scholar]
  137. Hirschl A. M., Rotter M. L. Serological tests for monitoring Helicobacter pylori eradication treatment. J Gastroenterol. 1996 Nov;31 (Suppl 9):33–36. [PubMed] [Google Scholar]
  138. Hu L. T., Mobley H. L. Expression of catalytically active recombinant Helicobacter pylori urease at wild-type levels in Escherichia coli. Infect Immun. 1993 Jun;61(6):2563–2569. doi: 10.1128/iai.61.6.2563-2569.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Hu L. T., Mobley H. L. Purification and N-terminal analysis of urease from Helicobacter pylori. Infect Immun. 1990 Apr;58(4):992–998. doi: 10.1128/iai.58.4.992-998.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Huang J., O'Toole P. W., Doig P., Trust T. J. Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori. Infect Immun. 1995 May;63(5):1732–1738. doi: 10.1128/iai.63.5.1732-1738.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  141. Hunter F. M., Correa P., Fontham E., Ruiz B., Sobhan M., Samloff I. M. Serum pepsinogens as markers of response to therapy for Helicobacter pylori gastritis. Dig Dis Sci. 1993 Nov;38(11):2081–2086. doi: 10.1007/BF01297088. [DOI] [PubMed] [Google Scholar]
  142. Husson M. O., Legrand D., Spik G., Leclerc H. Iron acquisition by Helicobacter pylori: importance of human lactoferrin. Infect Immun. 1993 Jun;61(6):2694–2697. doi: 10.1128/iai.61.6.2694-2697.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  143. Illingworth D. S., Walter K. S., Griffiths P. L., Barclay R. Siderophore production and iron-regulated envelope proteins of Helicobacter pylori. Zentralbl Bakteriol. 1993 Sep;280(1-2):113–119. [PubMed] [Google Scholar]
  144. Inouye H., Yamamoto I., Tanida N., Mikami J., Tamura K., Ohno T., Kano M., Shimoyama T. Campylobacter pylori in Japan: bacteriological feature and prevalence in healthy subjects and patients with gastroduodenal disorders. Gastroenterol Jpn. 1989 Oct;24(5):494–504. doi: 10.1007/BF02773875. [DOI] [PubMed] [Google Scholar]
  145. Janas B., Czkwianianc E., Bak-Romaniszyn L., Bartel H., Tosik D., Płaneta-Małecka I. Electron microscopic study of association between coccoid forms of Helicobacter pylori and gastric epithelial cells. Am J Gastroenterol. 1995 Oct;90(10):1829–1833. [PubMed] [Google Scholar]
  146. Jiang Q., Hiratsuka K., Taylor D. E. Variability of gene order in different Helicobacter pylori strains contributes to genome diversity. Mol Microbiol. 1996 May;20(4):833–842. doi: 10.1111/j.1365-2958.1996.tb02521.x. [DOI] [PubMed] [Google Scholar]
  147. Jones D. M., Lessells A. M., Eldridge J. Campylobacter like organisms on the gastric mucosa: culture, histological, and serological studies. J Clin Pathol. 1984 Sep;37(9):1002–1006. doi: 10.1136/jcp.37.9.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  148. Jonkers D., Stobberingh E., Stockbrügger R. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145–150. doi: 10.1093/jac/37.1.145. [DOI] [PubMed] [Google Scholar]
  149. Josenhans C., Labigne A., Suerbaum S. Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species. J Bacteriol. 1995 Jun;177(11):3010–3020. doi: 10.1128/jb.177.11.3010-3020.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  150. Karnes W. E., Jr, Samloff I. M., Siurala M., Kekki M., Sipponen P., Kim S. W., Walsh J. H. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991 Jul;101(1):167–174. doi: 10.1016/0016-5085(91)90474-y. [DOI] [PubMed] [Google Scholar]
  151. Kato S., Onda M., Matsukura N., Tokunaga A., Matsuda N., Yamashita K., Shields P. G. Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study. Cancer. 1996 Apr 15;77(8 Suppl):1654–1661. doi: 10.1002/(SICI)1097-0142(19960415)77:8<1654::AID-CNCR35>3.0.CO;2-X. [DOI] [PubMed] [Google Scholar]
  152. Katoh M., Saito D., Noda T., Yoshida S., Oguro Y., Yazaki Y., Sugimura T., Terada M. Helicobacter pylori may be transmitted through gastrofiberscope even after manual Hyamine washing. Jpn J Cancer Res. 1993 Feb;84(2):117–119. doi: 10.1111/j.1349-7006.1993.tb02843.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Kelly S. M., Pitcher M. C., Farmery S. M., Gibson G. R. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology. 1994 Dec;107(6):1671–1674. doi: 10.1016/0016-5085(94)90806-0. [DOI] [PubMed] [Google Scholar]
  154. Kirkland T., Viriyakosol S., Perez-Perez G. I., Blaser M. J. Helicobacter pylori lipopolysaccharide can activate 70Z/3 cells via CD14. Infect Immun. 1997 Feb;65(2):604–608. doi: 10.1128/iai.65.2.604-608.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Kist M., Spiegelhalder C., Moriki T., Schaefer H. E. Interaction of Helicobacter pylori (strain 151) and Campylobacter coli with human peripheral polymorphonuclear granulocytes. Zentralbl Bakteriol. 1993 Sep;280(1-2):58–72. doi: 10.1016/s0934-8840(11)80941-2. [DOI] [PubMed] [Google Scholar]
  156. Kleanthous H., Clayton C. L., Tabaqchali S. Characterization of a plasmid from Helicobacter pylori encoding a replication protein common to plasmids in gram-positive bacteria. Mol Microbiol. 1991 Oct;5(10):2377–2389. doi: 10.1111/j.1365-2958.1991.tb02084.x. [DOI] [PubMed] [Google Scholar]
  157. Klein P. D., Graham D. Y., Gaillour A., Opekun A. R., Smith E. O. Water source as risk factor for Helicobacter pylori infection in Peruvian children. Gastrointestinal Physiology Working Group. Lancet. 1991 Jun 22;337(8756):1503–1506. doi: 10.1016/0140-6736(91)93196-g. [DOI] [PubMed] [Google Scholar]
  158. Klein P. D., Malaty H. M., Martin R. F., Graham K. S., Genta R. M., Graham D. Y. Noninvasive detection of Helicobacter pylori infection in clinical practice: the 13C urea breath test. Am J Gastroenterol. 1996 Apr;91(4):690–694. [PubMed] [Google Scholar]
  159. Knipp U., Birkholz S., Kaup W., Opferkuch W. Immune suppressive effects of Helicobacter pylori on human peripheral blood mononuclear cells. Med Microbiol Immunol. 1993 May;182(2):63–76. doi: 10.1007/BF00189374. [DOI] [PubMed] [Google Scholar]
  160. Kobayashi Y., Okazaki K., Murakami K. Adhesion of Helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals. Infect Immun. 1993 Oct;61(10):4058–4063. doi: 10.1128/iai.61.10.4058-4063.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  161. Koletzko S., Haisch M., Seeboth I., Braden B., Hengels K., Koletzko B., Hering P. Isotope-selective non-dispersive infrared spectrometry for detection of Helicobacter pylori infection with 13C-urea breath test. Lancet. 1995 Apr 15;345(8955):961–962. doi: 10.1016/s0140-6736(95)90704-1. [DOI] [PubMed] [Google Scholar]
  162. Kolts B. E., Joseph B., Achem S. R., Bianchi T., Monteiro C. Helicobacter pylori detection: a quality and cost analysis. Am J Gastroenterol. 1993 May;88(5):650–655. [PubMed] [Google Scholar]
  163. Kosunen T. U., Seppälä K., Sarna S., Sipponen P. Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori. Lancet. 1992 Apr 11;339(8798):893–895. doi: 10.1016/0140-6736(92)90929-w. [DOI] [PubMed] [Google Scholar]
  164. Kuipers E. J., Pals G., Peña A. S., van Uffelen C. W., Kok A., Westerveld B. D., Meuwissen S. G. Helicobacter pylori, pepsinogens and gastrin: relationship with age and development of atrophic gastritis. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):153–156. doi: 10.1097/00042737-199602000-00012. [DOI] [PubMed] [Google Scholar]
  165. Lage A. P., Godfroid E., Fauconnier A., Burette A., Butzler J. P., Bollen A., Glupczynski Y. Diagnosis of Helicobacter pylori infection by PCR: comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens. J Clin Microbiol. 1995 Oct;33(10):2752–2756. doi: 10.1128/jcm.33.10.2752-2756.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  166. Laine L., Chun D., Stein C., El-Beblawi I., Sharma V., Chandrasoma P. The influence of size or number of biopsies on rapid urease test results: a prospective evaluation. Gastrointest Endosc. 1996 Jan;43(1):49–53. doi: 10.1016/s0016-5107(96)70260-2. [DOI] [PubMed] [Google Scholar]
  167. Laine L., Cohen H., Sloane R., Marin-Sorensen M., Weinstein W. M. Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointest Endosc. 1995 Nov;42(5):420–423. doi: 10.1016/s0016-5107(95)70043-9. [DOI] [PubMed] [Google Scholar]
  168. Laine L., Estrada R., Lewin D. N., Cohen H. The influence of warming on rapid urease test results: a prospective evaluation. Gastrointest Endosc. 1996 Oct;44(4):429–432. doi: 10.1016/s0016-5107(96)70094-9. [DOI] [PubMed] [Google Scholar]
  169. Laine L., Lewin D. N., Naritoku W., Cohen H. Prospective comparison of H&E, Giemsa, and Genta stains for the diagnosis of Helicobacter pylori. Gastrointest Endosc. 1997 Jun;45(6):463–467. doi: 10.1016/s0016-5107(97)70174-3. [DOI] [PubMed] [Google Scholar]
  170. Laine L., Lewin D., Naritoku W., Estrada R., Cohen H. Prospective comparison of commercially available rapid urease tests for the diagnosis of Helicobacter pylori. Gastrointest Endosc. 1996 Nov;44(5):523–526. doi: 10.1016/s0016-5107(96)70002-0. [DOI] [PubMed] [Google Scholar]
  171. Laine L., Stein C., Neil G. Limited efficacy of omeprazole-based dual and triple therapy for Helicobacter pylori: a randomized trial employing "optimal" dosing. Am J Gastroenterol. 1995 Sep;90(9):1407–1410. [PubMed] [Google Scholar]
  172. Lee C. K., Weltzin R., Thomas W. D., Jr, Kleanthous H., Ermak T. H., Soman G., Hill J. E., Ackerman S. K., Monath T. P. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J Infect Dis. 1995 Jul;172(1):161–172. doi: 10.1093/infdis/172.1.161. [DOI] [PubMed] [Google Scholar]
  173. Lelwala-Guruge J., Ascencio F., Kreger A. S., Ljungh A., Wadström T. Isolation of a sialic acid-specific surface haemagglutinin of Helicobacter pylori strain NCTC 11637. Zentralbl Bakteriol. 1993 Sep;280(1-2):93–106. doi: 10.1016/s0934-8840(11)80944-8. [DOI] [PubMed] [Google Scholar]
  174. Lelwala-Guruge J., Ascencio F., Ljungh A., Wadström T. Rapid detection and characterization of sialic acid-specific lectins of Helicobacter pylori. APMIS. 1993 Sep;101(9):695–702. doi: 10.1111/j.1699-0463.1993.tb00167.x. [DOI] [PubMed] [Google Scholar]
  175. Leunk R. D., Johnson P. T., David B. C., Kraft W. G., Morgan D. R. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol. 1988 Jun;26(2):93–99. doi: 10.1099/00222615-26-2-93. [DOI] [PubMed] [Google Scholar]
  176. Li C., Ha T., Ferguson D. A., Jr, Chi D. S., Zhao R., Patel N. R., Krishnaswamy G., Thomas E. A newly developed PCR assay of H. pylori in gastric biopsy, saliva, and feces. Evidence of high prevalence of H. pylori in saliva supports oral transmission. Dig Dis Sci. 1996 Nov;41(11):2142–2149. doi: 10.1007/BF02071393. [DOI] [PubMed] [Google Scholar]
  177. Lind T., Veldhuyzen van Zanten S., Unge P., Spiller R., Bayerdörffer E., O'Morain C., Bardhan K. D., Bradette M., Chiba N., Wrangstadh M. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study. Helicobacter. 1996 Sep;1(3):138–144. doi: 10.1111/j.1523-5378.1996.tb00027.x. [DOI] [PubMed] [Google Scholar]
  178. Lingwood C. A., Wasfy G., Han H., Huesca M. Receptor affinity purification of a lipid-binding adhesin from Helicobacter pylori. Infect Immun. 1993 Jun;61(6):2474–2478. doi: 10.1128/iai.61.6.2474-2478.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  179. Lip G. H., Wise R., Beevers G. Association of Helicobacter pylori infection with coronary heart disease. Study shows association between H pylori infection and hypertension. BMJ. 1996 Jan 27;312(7025):250–251. doi: 10.1136/bmj.312.7025.250b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  180. Logan R. P., Berg D. E. Genetic diversity of Helicobacter pylori. Lancet. 1996 Nov 30;348(9040):1462–1463. doi: 10.1016/s0140-6736(05)65885-0. [DOI] [PubMed] [Google Scholar]
  181. Logan R. P., Walker M. M., Misiewicz J. J., Gummett P. A., Karim Q. N., Baron J. H. Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut. 1995 Jan;36(1):12–16. doi: 10.1136/gut.36.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  182. Loy C. T., Irwig L. M., Katelaris P. H., Talley N. J. Do commercial serological kits for Helicobacter pylori infection differ in accuracy? A meta-analysis. Am J Gastroenterol. 1996 Jun;91(6):1138–1144. [PubMed] [Google Scholar]
  183. Luke C. J., Penn C. W. Identification of a 29 kDa flagellar sheath protein in Helicobacter pylori using a murine monoclonal antibody. Microbiology. 1995 Mar;141(Pt 3):597–604. doi: 10.1099/13500872-141-3-597. [DOI] [PubMed] [Google Scholar]
  184. Macchia G., Massone A., Burroni D., Covacci A., Censini S., Rappuoli R. The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases. Mol Microbiol. 1993 Aug;9(3):645–652. doi: 10.1111/j.1365-2958.1993.tb01724.x. [DOI] [PubMed] [Google Scholar]
  185. Mannick E. E., Bravo L. E., Zarama G., Realpe J. L., Zhang X. J., Ruiz B., Fontham E. T., Mera R., Miller M. J., Correa P. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res. 1996 Jul 15;56(14):3238–3243. [PubMed] [Google Scholar]
  186. Marcelli S. W., Chang H. T., Chapman T., Chalk P. A., Miles R. J., Poole R. K. The respiratory chain of Helicobacter pylori: identification of cytochromes and the effects of oxygen on cytochrome and menaquinone levels. FEMS Microbiol Lett. 1996 Apr 15;138(1):59–64. doi: 10.1111/j.1574-6968.1996.tb08135.x. [DOI] [PubMed] [Google Scholar]
  187. Marchetti M., Aricò B., Burroni D., Figura N., Rappuoli R., Ghiara P. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science. 1995 Mar 17;267(5204):1655–1658. doi: 10.1126/science.7886456. [DOI] [PubMed] [Google Scholar]
  188. Marchini A., d'Apolito M., Massari P., Atzeni M., Copass M., Olivieri R. Cyclodextrins for growth of Helicobacter pylori and production of vacuolating cytotoxin. Arch Microbiol. 1995 Oct;164(4):290–293. doi: 10.1007/BF02529963. [DOI] [PubMed] [Google Scholar]
  189. Marshall B. J., Armstrong J. A., McGechie D. B., Glancy R. J. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 1985 Apr 15;142(8):436–439. doi: 10.5694/j.1326-5377.1985.tb113443.x. [DOI] [PubMed] [Google Scholar]
  190. Marshall B. J., Warren J. R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984 Jun 16;1(8390):1311–1315. doi: 10.1016/s0140-6736(84)91816-6. [DOI] [PubMed] [Google Scholar]
  191. Mauch F., Bode G., Ditschuneit H., Malfertheiner P. Demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by Helicobacter pylori. Gastroenterology. 1993 Dec;105(6):1698–1704. doi: 10.1016/0016-5085(93)91065-p. [DOI] [PubMed] [Google Scholar]
  192. McNulty C. A., Watson D. M. Spiral bacteria of the gastric antrum. Lancet. 1984 May 12;1(8385):1068–1069. doi: 10.1016/s0140-6736(84)91469-7. [DOI] [PubMed] [Google Scholar]
  193. Melchers K., Weitzenegger T., Buhmann A., Steinhilber W., Sachs G., Schäfer K. P. Cloning and membrane topology of a P type ATPase from Helicobacter pylori. J Biol Chem. 1996 Jan 5;271(1):446–457. doi: 10.1074/jbc.271.1.446. [DOI] [PubMed] [Google Scholar]
  194. Mendall M. A., Goggin P. M., Molineaux N., Levy J., Toosy T., Strachan D., Camm A. J., Northfield T. C. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J. 1994 May;71(5):437–439. doi: 10.1136/hrt.71.5.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  195. Mendall M. A., Goggin P. M., Molineaux N., Levy J., Toosy T., Strachan D., Northfield T. C. Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet. 1992 Apr 11;339(8798):896–897. doi: 10.1016/0140-6736(92)90931-r. [DOI] [PubMed] [Google Scholar]
  196. Mendz G. L., Burns B. P., Hazell S. L. Characterisation of glucose transport in Helicobacter pylori. Biochim Biophys Acta. 1995 Jun 9;1244(2-3):269–276. doi: 10.1016/0304-4165(95)00018-7. [DOI] [PubMed] [Google Scholar]
  197. Mendz G. L., Hazell S. L. Aminoacid utilization by Helicobacter pylori. Int J Biochem Cell Biol. 1995 Oct;27(10):1085–1093. doi: 10.1016/1357-2725(95)00069-2. [DOI] [PubMed] [Google Scholar]
  198. Mendz G. L., Hazell S. L., Burns B. P. The Entner-Doudoroff pathway in Helicobacter pylori. Arch Biochem Biophys. 1994 Aug 1;312(2):349–356. doi: 10.1006/abbi.1994.1319. [DOI] [PubMed] [Google Scholar]
  199. Mendz G. L., Hazell S. L., Srinivasan S. Fumarate reductase: a target for therapeutic intervention against Helicobacter pylori. Arch Biochem Biophys. 1995 Aug 1;321(1):153–159. doi: 10.1006/abbi.1995.1380. [DOI] [PubMed] [Google Scholar]
  200. Mendz G. L., Hazell S. L. The urea cycle of Helicobacter pylori. Microbiology. 1996 Oct;142(Pt 10):2959–2967. doi: 10.1099/13500872-142-10-2959. [DOI] [PubMed] [Google Scholar]
  201. Micots I., Augeron C., Laboisse C. L., Muzeau F., Mégraud F. Mucin exocytosis: a major target for Helicobacter pylori. J Clin Pathol. 1993 Mar;46(3):241–245. doi: 10.1136/jcp.46.3.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  202. Miehlke S., Kibler K., Kim J. G., Figura N., Small S. M., Graham D. Y., Go M. F. Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States. Am J Gastroenterol. 1996 Jul;91(7):1322–1325. [PubMed] [Google Scholar]
  203. Minnis J. A., Taylor T. E., Knesek J. E., Peterson W. L., McIntire S. A. Characterization of a 3.5-kbp plasmid from Helicobacter pylori. Plasmid. 1995 Jul;34(1):22–36. doi: 10.1006/plas.1995.1030. [DOI] [PubMed] [Google Scholar]
  204. Mitchell H. M., Lee A., Carrick J. Increased incidence of Campylobacter pylori infection in gastroenterologists: further evidence to support person-to-person transmission of C. pylori. Scand J Gastroenterol. 1989 May;24(4):396–400. doi: 10.3109/00365528909093065. [DOI] [PubMed] [Google Scholar]
  205. Mobley H. L., Garner R. M., Bauerfeind P. Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions. Mol Microbiol. 1995 Apr;16(1):97–109. doi: 10.1111/j.1365-2958.1995.tb02395.x. [DOI] [PubMed] [Google Scholar]
  206. Mobley H. L., Island M. D., Hausinger R. P. Molecular biology of microbial ureases. Microbiol Rev. 1995 Sep;59(3):451–480. doi: 10.1128/mr.59.3.451-480.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  207. Molyneux A. J., Harris M. D. Helicobacter pylori in gastric biopsies--should you trust the pathology report? J R Coll Physicians Lond. 1993 Apr;27(2):119–120. [PMC free article] [PubMed] [Google Scholar]
  208. Moran A. P. The role of lipopolysaccharide in Helicobacter pylori pathogenesis. Aliment Pharmacol Ther. 1996 Apr;10 (Suppl 1):39–50. doi: 10.1046/j.1365-2036.1996.22164004.x. [DOI] [PubMed] [Google Scholar]
  209. Morris A., Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol. 1987 Mar;82(3):192–199. [PubMed] [Google Scholar]
  210. Morris A., Nicholson G., Zwi J., Vanderwee M. Campylobacter pylori infection in Meckel's diverticula containing gastric mucosa. Gut. 1989 Sep;30(9):1233–1235. doi: 10.1136/gut.30.9.1233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  211. Moss S. F., Calam J., Agarwal B., Wang S., Holt P. R. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut. 1996 Apr;38(4):498–501. doi: 10.1136/gut.38.4.498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  212. Moulton-Barrett R., Triadafilopoulos G., Michener R., Gologorsky D. Serum 13C-bicarbonate in the assessment of gastric Helicobacter pylori urease activity. Am J Gastroenterol. 1993 Mar;88(3):369–374. [PubMed] [Google Scholar]
  213. Muotiala A., Helander I. M., Pyhälä L., Kosunen T. U., Moran A. P. Low biological activity of Helicobacter pylori lipopolysaccharide. Infect Immun. 1992 Apr;60(4):1714–1716. doi: 10.1128/iai.60.4.1714-1716.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  214. Mégraud F. Transmission of Helicobacter pylori: faecal-oral versus oral-oral route. Aliment Pharmacol Ther. 1995;9 (Suppl 2):85–91. [PubMed] [Google Scholar]
  215. Nagata K., Satoh H., Iwahi T., Shimoyama T., Tamura T. Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H. pylori cells. Antimicrob Agents Chemother. 1993 Apr;37(4):769–774. doi: 10.1128/aac.37.4.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  216. Nagata K., Tsukita S., Tamura T., Sone N. A cb-type cytochrome-c oxidase terminates the respiratory chain in Helicobacter pylori. Microbiology. 1996 Jul;142(Pt 7):1757–1763. doi: 10.1099/13500872-142-7-1757. [DOI] [PubMed] [Google Scholar]
  217. Nakao M., Tada M., Tsuchimori K., Uekata M. Antibacterial properties of lansoprazole alone and in combination with antimicrobial agents against Helicobacter pylori. Eur J Clin Microbiol Infect Dis. 1995 May;14(5):391–399. doi: 10.1007/BF02114894. [DOI] [PubMed] [Google Scholar]
  218. Neugut A. I., Hayek M., Howe G. Epidemiology of gastric cancer. Semin Oncol. 1996 Jun;23(3):281–291. [PubMed] [Google Scholar]
  219. Nightingale S. L. From the Food and Drug Administration. JAMA. 1996 Dec 4;276(21):1710–1710. [PubMed] [Google Scholar]
  220. Nilius M., Ströhle A., Bode G., Malfertheiner P. Coccoid like forms (CLF) of Helicobacter pylori. Enzyme activity and antigenicity. Zentralbl Bakteriol. 1993 Sep;280(1-2):259–272. doi: 10.1016/s0934-8840(11)80964-3. [DOI] [PubMed] [Google Scholar]
  221. Nomura A., Stemmermann G. N., Chyou P. H., Kato I., Perez-Perez G. I., Blaser M. J. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991 Oct 17;325(16):1132–1136. doi: 10.1056/NEJM199110173251604. [DOI] [PubMed] [Google Scholar]
  222. O'Toole P. W., Kostrzynska M., Trust T. J. Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production. Mol Microbiol. 1994 Nov;14(4):691–703. doi: 10.1111/j.1365-2958.1994.tb01307.x. [DOI] [PubMed] [Google Scholar]
  223. Odenbreit S., Wieland B., Haas R. Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain. J Bacteriol. 1996 Dec;178(23):6960–6967. doi: 10.1128/jb.178.23.6960-6967.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  224. Oderda G., Vaira D., Holton J., Ainley C., Altare F., Ansaldi N. Amoxycillin plus tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels. Lancet. 1989 Apr 1;1(8640):690–692. doi: 10.1016/s0140-6736(89)92206-x. [DOI] [PubMed] [Google Scholar]
  225. Oliva M. M., Lazenby A. J., Perman J. A. Gastritis associated with Gastrospirillum hominis in children. Comparison with Helicobacter pylori and review of the literature. Mod Pathol. 1993 Sep;6(5):513–515. [PubMed] [Google Scholar]
  226. Ottlecz A., Romero J. J., Hazell S. L., Graham D. Y., Lichtenberger L. M. Phospholipase activity of Helicobacter pylori and its inhibition by bismuth salts. Biochemical and biophysical studies. Dig Dis Sci. 1993 Nov;38(11):2071–2080. doi: 10.1007/BF01297087. [DOI] [PubMed] [Google Scholar]
  228. Papini E., de Bernard M., Milia E., Bugnoli M., Zerial M., Rappuoli R., Montecucco C. Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9720–9724. doi: 10.1073/pnas.91.21.9720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  229. Parsonnet J., Blaser M. J., Perez-Perez G. I., Hargrett-Bean N., Tauxe R. V. Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology. 1992 Jan;102(1):41–46. doi: 10.1016/0016-5085(92)91782-y. [DOI] [PubMed] [Google Scholar]
  230. Parsonnet J., Friedman G. D., Vandersteen D. P., Chang Y., Vogelman J. H., Orentreich N., Sibley R. K. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991 Oct 17;325(16):1127–1131. doi: 10.1056/NEJM199110173251603. [DOI] [PubMed] [Google Scholar]
  231. Parsonnet J., Hansen S., Rodriguez L., Gelb A. B., Warnke R. A., Jellum E., Orentreich N., Vogelman J. H., Friedman G. D. Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 1994 May 5;330(18):1267–1271. doi: 10.1056/NEJM199405053301803. [DOI] [PubMed] [Google Scholar]
  232. Parsonnet J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther. 1995;9 (Suppl 2):45–51. [PubMed] [Google Scholar]
  233. Patchett S., Beattie S., Leen E., Keane C., O'Morain C. Helicobacter pylori and duodenal ulcer recurrence. Am J Gastroenterol. 1992 Jan;87(1):24–27. [PubMed] [Google Scholar]
  234. Patel P., Mendall M. A., Carrington D., Strachan D. P., Leatham E., Molineaux N., Levy J., Blakeston C., Seymour C. A., Camm A. J. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ. 1995 Sep 16;311(7007):711–714. doi: 10.1136/bmj.311.7007.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  235. Patel P., Mendall M. A., Khulusi S., Molineaux N., Levy J., Maxwell J. D., Northfield T. C. Salivary antibodies to Helicobacter pylori: screening dyspeptic patients before endoscopy. Lancet. 1994 Aug 20;344(8921):511–512. doi: 10.1016/s0140-6736(94)91899-6. [DOI] [PubMed] [Google Scholar]
  236. Patel P., Mendall M. A., Khulusi S., Northfield T. C., Strachan D. P. Helicobacter pylori infection in childhood: risk factors and effect on growth. BMJ. 1994 Oct 29;309(6962):1119–1123. doi: 10.1136/bmj.309.6962.1119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  237. Pathak C. M., Bhasin D. K., Panigrahi D., Goel R. C. Evaluation of 14C-urinary excretion and its comparison with 14CO2 in breath after 14C-urea administration in Helicobacter pylori infection. Am J Gastroenterol. 1994 May;89(5):734–738. [PubMed] [Google Scholar]
  238. Peek R. M., Jr, Miller G. G., Tham K. T., Pérez-Pérez G. I., Cover T. L., Atherton J. C., Dunn G. D., Blaser M. J. Detection of Helicobacter pylori gene expression in human gastric mucosa. J Clin Microbiol. 1995 Jan;33(1):28–32. doi: 10.1128/jcm.33.1.28-32.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  239. Penston J. G. Review article: Helicobacter pylori eradication--understandable caution but no excuse for inertia. Aliment Pharmacol Ther. 1994 Aug;8(4):369–389. doi: 10.1111/j.1365-2036.1994.tb00304.x. [DOI] [PubMed] [Google Scholar]
  240. Perez-Perez G. I., Dworkin B. M., Chodos J. E., Blaser M. J. Campylobacter pylori antibodies in humans. Ann Intern Med. 1988 Jul 1;109(1):11–17. doi: 10.7326/0003-4819-109-1-11. [DOI] [PubMed] [Google Scholar]
  241. Perez-Perez G. I., Witkin S. S., Decker M. D., Blaser M. J. Seroprevalence of helicobacter pylori infection in couples. J Clin Microbiol. 1991 Mar;29(3):642–644. doi: 10.1128/jcm.29.3.642-644.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  242. Peterson W. L., Graham D. Y., Marshall B., Blaser M. J., Genta R. M., Klein P. D., Stratton C. W., Drnec J., Prokocimer P., Siepman N. Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. Am J Gastroenterol. 1993 Nov;88(11):1860–1864. [PubMed] [Google Scholar]
  243. Peterson W. L. Helicobacter pylori and peptic ulcer disease. N Engl J Med. 1991 Apr 11;324(15):1043–1048. doi: 10.1056/NEJM199104113241507. [DOI] [PubMed] [Google Scholar]
  244. Peura D. A., Pambianco D. J., Dye K. R., Lind C., Frierson H. F., Hoffman S. R., Combs M. J., Guilfoyle E., Marshall B. J. Microdose 14C-urea breath test offers diagnosis of Helicobacter pylori in 10 minutes. Am J Gastroenterol. 1996 Feb;91(2):233–238. [PubMed] [Google Scholar]
  245. Phadnis S. H., Ilver D., Janzon L., Normark S., Westblom T. U. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun. 1994 May;62(5):1557–1565. doi: 10.1128/iai.62.5.1557-1565.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  246. Phadnis S. H., Parlow M. H., Levy M., Ilver D., Caulkins C. M., Connors J. B., Dunn B. E. Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis. Infect Immun. 1996 Mar;64(3):905–912. doi: 10.1128/iai.64.3.905-912.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  247. Pilotto A., Franceschi M., Leandro G., DiMario F., Soffiati G., Scagnelli M., Bozzola L., Fabrello R., Valerio G. The clinical usefulness of serum pepsinogens, specific IgG anti-HP antibodies and gastrin for monitoring Helicobacter pylori treatment in older people. J Am Geriatr Soc. 1996 Jun;44(6):665–670. doi: 10.1111/j.1532-5415.1996.tb01829.x. [DOI] [PubMed] [Google Scholar]
  248. Piotrowski J., Piotrowski E., Slomiany A., Slomiany B. L. Susceptibility of Helicobacter pylori to antimicrobial agents: effect of ebrotidine and ranitidine. J Physiol Pharmacol. 1995 Dec;46(4):463–469. [PubMed] [Google Scholar]
  249. Piotrowski J., Slomiany A., Slomiany B. L. Inhibition of Helicobacter pylori urease activity by ebrotidine. Biochem Mol Biol Int. 1995 Oct;37(2):247–253. [PubMed] [Google Scholar]
  250. Polish L. B., Douglas J. M., Jr, Davidson A. J., Perez-Perez G. I., Blaser M. J. Characterization of risk factors for Helicobacter pylori infection among men attending a sexually transmitted disease clinic: lack of evidence for sexual transmission. J Clin Microbiol. 1991 Oct;29(10):2139–2143. doi: 10.1128/jcm.29.10.2139-2143.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  251. Pérez-Pérez G. I., Gower C. B., Blaser M. J. Effects of cations on Helicobacter pylori urease activity, release, and stability. Infect Immun. 1994 Jan;62(1):299–302. doi: 10.1128/iai.62.1.299-302.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  252. Queiroz D. M., Mendes E. N., Rocha G. A. Indicator medium for isolation of Campylobacter pylori. J Clin Microbiol. 1987 Dec;25(12):2378–2379. doi: 10.1128/jcm.25.12.2378-2379.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  253. Raju G. S., Smith M. J., Morton D., Bardhan K. D. Mini-dose (1-microCi) 14C-urea breath test for the detection of Helicobacter pylori. Am J Gastroenterol. 1994 Jul;89(7):1027–1031. [PubMed] [Google Scholar]
  254. Replogle M. L., Glaser S. L., Hiatt R. A., Parsonnet J. Biologic sex as a risk factor for Helicobacter pylori infection in healthy young adults. Am J Epidemiol. 1995 Oct 15;142(8):856–863. doi: 10.1093/oxfordjournals.aje.a117725. [DOI] [PubMed] [Google Scholar]
  255. Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori. European Study Group on Antibiotic Susceptibility of Helicobacter pylori. Eur J Clin Microbiol Infect Dis. 1992 Sep;11(9):777–781. [PubMed] [Google Scholar]
  256. Ricci V., Ciacci C., Zarrilli R., Sommi P., Tummuru M. K., Del Vecchio Blanco C., Bruni C. B., Cover T. L., Blaser M. J., Romano M. Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA. Infect Immun. 1996 Jul;64(7):2829–2833. doi: 10.1128/iai.64.7.2829-2833.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  257. Ringnér M., Aleljung P., Wadström T. Adherence of haemagglutinating Helicobacter pylori to five cell lines. Zentralbl Bakteriol. 1993 Sep;280(1-2):107–112. doi: 10.1016/s0934-8840(11)80945-x. [DOI] [PubMed] [Google Scholar]
  258. Salim A. S. The relationship between Helicobacter pylori and oxygen-derived free radicals in the mechanism of duodenal ulceration. Intern Med. 1993 May;32(5):359–364. doi: 10.2169/internalmedicine.32.359. [DOI] [PubMed] [Google Scholar]
  259. Sandifer Q. D., Vuilo S., Crompton G. Association of Helicobacter pylori infection with coronary heart disease. Association may not be causal. BMJ. 1996 Jan 27;312(7025):251–251. doi: 10.1136/bmj.312.7025.251a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  260. Schmitt W., Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol. 1994 Apr;12(2):307–319. doi: 10.1111/j.1365-2958.1994.tb01019.x. [DOI] [PubMed] [Google Scholar]
  261. Sharma S. A., Tummuru M. K., Miller G. G., Blaser M. J. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect Immun. 1995 May;63(5):1681–1687. doi: 10.1128/iai.63.5.1681-1687.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  262. Sherburne R., Taylor D. E. Helicobacter pylori expresses a complex surface carbohydrate, Lewis X. Infect Immun. 1995 Dec;63(12):4564–4568. doi: 10.1128/iai.63.12.4564-4568.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  263. Simoons-Smit I. M., Appelmelk B. J., Verboom T., Negrini R., Penner J. L., Aspinall G. O., Moran A. P., Fei S. F., Shi B. S., Rudnica W. Typing of Helicobacter pylori with monoclonal antibodies against Lewis antigens in lipopolysaccharide. J Clin Microbiol. 1996 Sep;34(9):2196–2200. doi: 10.1128/jcm.34.9.2196-2200.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  264. Simor A. E., Lin E., Saibil F., Cohen L., Louie M., Pearen S., Donhoffer H. A. Evaluation of enzyme immunoassay for detection of salivary antibody to Helicobacter pylori. J Clin Microbiol. 1996 Mar;34(3):550–553. doi: 10.1128/jcm.34.3.550-553.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  265. Smith A. W., Chahal B., French G. L. The human gastric pathogen Helicobacter pylori has a gene encoding an enzyme first classified as a mucinase in Vibrio cholerae. Mol Microbiol. 1994 Jul;13(1):153–160. doi: 10.1111/j.1365-2958.1994.tb00410.x. [DOI] [PubMed] [Google Scholar]
  266. Smoot D. T., Mobley H. L., Chippendale G. R., Lewison J. F., Resau J. H. Helicobacter pylori urease activity is toxic to human gastric epithelial cells. Infect Immun. 1990 Jun;58(6):1992–1994. doi: 10.1128/iai.58.6.1992-1994.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  267. Sobala G. M., Crabtree J. E., Dixon M. F., Schorah C. J., Taylor J. D., Rathbone B. J., Heatley R. V., Axon A. T. Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut. 1991 Nov;32(11):1415–1418. doi: 10.1136/gut.32.11.1415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  268. Sobhani I., Bado A., Cherifi Y., Moizo L., Laigneau J. P., Pospai D., Mignon M., Lewin Helicobacter pylori stimulates gastric acid secretion via platelet activating factor. J Physiol Pharmacol. 1996 Mar;47(1):177–185. [PubMed] [Google Scholar]
  269. Sobhani I., Denizot Y., Vissuzaine C., Vatier J., Benveniste J., Lewin M. J., Mignon M. Significance and regulation of gastric secretion of platelet-activating factor (PAF-acether) in man. Dig Dis Sci. 1992 Oct;37(10):1583–1592. doi: 10.1007/BF01296506. [DOI] [PubMed] [Google Scholar]
  270. Soll A. H. Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology. JAMA. 1996 Feb 28;275(8):622–629. doi: 10.1001/jama.275.8.622. [DOI] [PubMed] [Google Scholar]
  271. Solnick J. V., O'Rourke J., Lee A., Paster B. J., Dewhirst F. E., Tompkins L. S. An uncultured gastric spiral organism is a newly identified Helicobacter in humans. J Infect Dis. 1993 Aug;168(2):379–385. doi: 10.1093/infdis/168.2.379. [DOI] [PubMed] [Google Scholar]
  272. Spiegelhalder C., Gerstenecker B., Kersten A., Schiltz E., Kist M. Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene. Infect Immun. 1993 Dec;61(12):5315–5325. doi: 10.1128/iai.61.12.5315-5325.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  273. Stolte M., Wellens E., Bethke B., Ritter M., Eidt H. Helicobacter heilmannii (formerly Gastrospirillum hominis) gastritis: an infection transmitted by animals? Scand J Gastroenterol. 1994 Dec;29(12):1061–1064. doi: 10.3109/00365529409094888. [DOI] [PubMed] [Google Scholar]
  274. Stubbs J. B., Marshall B. J. Radiation dose estimates for the carbon-14-labeled urea breath test. J Nucl Med. 1993 May;34(5):821–825. [PubMed] [Google Scholar]
  275. Suerbaum S., Josenhans C., Labigne A. Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange. J Bacteriol. 1993 Jun;175(11):3278–3288. doi: 10.1128/jb.175.11.3278-3288.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  276. Suerbaum S., Thiberge J. M., Kansau I., Ferrero R. L., Labigne A. Helicobacter pylori hspA-hspB heat-shock gene cluster: nucleotide sequence, expression, putative function and immunogenicity. Mol Microbiol. 1994 Dec;14(5):959–974. doi: 10.1111/j.1365-2958.1994.tb01331.x. [DOI] [PubMed] [Google Scholar]
  277. Sumii M., Sumii K., Tari A., Kawaguchi H., Yamamoto G., Takehara Y., Fukino Y., Kamiyasu T., Hamada M., Tsuda T. Expression of antral gastrin and somatostatin mRNA in Helicobacter pylori-infected subjects. Am J Gastroenterol. 1994 Sep;89(9):1515–1519. [PubMed] [Google Scholar]
  278. Sung J. J., Chung S. C., Ling T. K., Yung M. Y., Leung V. K., Ng E. K., Li M. K., Cheng A. F., Li A. K. Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. N Engl J Med. 1995 Jan 19;332(3):139–142. doi: 10.1056/NEJM199501193320302. [DOI] [PubMed] [Google Scholar]
  279. Suzuki M., Nakamura M., Mori M., Miura S., Tsuchiya M., Ishii H. Lansoprazole inhibits oxygen-derived free radical production from neutrophils activated by Helicobacter pylori. J Clin Gastroenterol. 1995;20 (Suppl 2):S93–S96. doi: 10.1097/00004836-199506002-00025. [DOI] [PubMed] [Google Scholar]
  280. Tabak M., Armon R., Potasman I., Neeman I. In vitro inhibition of Helicobacter pylori by extracts of thyme. J Appl Bacteriol. 1996 Jun;80(6):667–672. doi: 10.1111/j.1365-2672.1996.tb03272.x. [DOI] [PubMed] [Google Scholar]
  281. Talley N. J., Zinsmeister A. R., Weaver A., DiMagno E. P., Carpenter H. A., Perez-Perez G. I., Blaser M. J. Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst. 1991 Dec 4;83(23):1734–1739. doi: 10.1093/jnci/83.23.1734. [DOI] [PubMed] [Google Scholar]
  282. Taylor D. E., Eaton M., Chang N., Salama S. M. Construction of a Helicobacter pylori genome map and demonstration of diversity at the genome level. J Bacteriol. 1992 Nov;174(21):6800–6806. doi: 10.1128/jb.174.21.6800-6806.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  283. Telford J. L., Ghiara P., Dell'Orco M., Comanducci M., Burroni D., Bugnoli M., Tecce M. F., Censini S., Covacci A., Xiang Z. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med. 1994 May 1;179(5):1653–1658. doi: 10.1084/jem.179.5.1653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  284. Thomas J. E., Gibson G. R., Darboe M. K., Dale A., Weaver L. T. Isolation of Helicobacter pylori from human faeces. Lancet. 1992 Nov 14;340(8829):1194–1195. doi: 10.1016/0140-6736(92)92894-l. [DOI] [PubMed] [Google Scholar]
  285. Tsuda M., Karita M., Morshed M. G., Okita K., Nakazawa T. A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. Infect Immun. 1994 Aug;62(8):3586–3589. doi: 10.1128/iai.62.8.3586-3589.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  286. Tucci A., Corinaldesi R., Stanghellini V., Paparo G. F., Gasperoni S., Biasco G., Varoli O., Ricci-Maccarini M., Barbara L. One-day therapy for treatment of Helicobacter pylori infection. Dig Dis Sci. 1993 Sep;38(9):1670–1673. doi: 10.1007/BF01303176. [DOI] [PubMed] [Google Scholar]
  287. Tummuru M. K., Cover T. L., Blaser M. J. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun. 1993 May;61(5):1799–1809. doi: 10.1128/iai.61.5.1799-1809.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  288. Tummuru M. K., Sharma S. A., Blaser M. J. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol. 1995 Dec;18(5):867–876. doi: 10.1111/j.1365-2958.1995.18050867.x. [DOI] [PubMed] [Google Scholar]
  289. Tytgat G. N. Endoscopic transmission of Helicobacter pylori. Aliment Pharmacol Ther. 1995;9 (Suppl 2):105–110. [PubMed] [Google Scholar]
  290. Unge P. Review of Helicobacter pylori eradication regimens. Scand J Gastroenterol Suppl. 1996;215:74–81. [PubMed] [Google Scholar]
  291. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983 Jun 4;1(8336):1273–1275. [PubMed] [Google Scholar]
  292. Valkonen K. H., Ringner M., Ljungh A., Wadström T. High-affinity binding of laminin by Helicobacter pylori: evidence for a lectin-like interaction. FEMS Immunol Med Microbiol. 1993 Jun;7(1):29–37. doi: 10.1111/j.1574-695X.1993.tb00378.x. [DOI] [PubMed] [Google Scholar]
  293. Valle J., Seppälä K., Sipponen P., Kosunen T. Disappearance of gastritis after eradication of Helicobacter pylori. A morphometric study. Scand J Gastroenterol. 1991 Oct;26(10):1057–1065. doi: 10.3109/00365529109003956. [DOI] [PubMed] [Google Scholar]
  294. Vandenplas Y., Blecker U., Devreker T., Keppens E., Nijs J., Cadranel S., Pipeleers-Marichal M., Goossens A., Lauwers S. Contribution of the 13C-urea breath test to the detection of Helicobacter pylori gastritis in children. Pediatrics. 1992 Oct;90(4):608–611. [PubMed] [Google Scholar]
  295. Vasquez A., Valdez Y., Gilman R. H., McDonald J. J., Westblom T. U., Berg D., Mayta H., Gutierrez V. Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. The Gastrointestinal Physiology Working Group of Universidad Peruana Cayetano Heredia and the Johns Hopkins University. J Clin Microbiol. 1996 May;34(5):1232–1234. doi: 10.1128/jcm.34.5.1232-1234.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  296. Veenendaal R. A., Lichtendahl-Bernards A. T., Peña A. S., Endtz H. P., van Boven C. P., Lamers C. B. Effect of transport medium and transportation time on culture of Helicobacter pylori from gastric biopsy specimens. J Clin Pathol. 1993 Jun;46(6):561–563. doi: 10.1136/jcp.46.6.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  297. Walt R. P. Regression of MALT lymphoma and treatment for Helicobacter pylori. Lancet. 1996 Oct 12;348(9033):1041–1042. doi: 10.1016/s0140-6736(05)64980-x. [DOI] [PubMed] [Google Scholar]
  298. Weel J. F., van der Hulst R. W., Gerrits Y., Tytgat G. N., van der Ende A., Dankert J. Heterogeneity in susceptibility to metronidazole among Helicobacter pylori isolates from patients with gastritis or peptic ulcer disease. J Clin Microbiol. 1996 Sep;34(9):2158–2162. doi: 10.1128/jcm.34.9.2158-2162.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  299. Weitkamp J. H., Pérez-Pérez G. I., Bode G., Malfertheiner P., Blaser M. J. Identification and characterization of Helicobacter pylori phospholipase C activity. Zentralbl Bakteriol. 1993 Sep;280(1-2):11–27. doi: 10.1016/s0934-8840(11)80937-0. [DOI] [PubMed] [Google Scholar]
  300. Wilson K. T., Ramanujam K. S., Mobley H. L., Musselman R. F., James S. P., Meltzer S. J. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology. 1996 Dec;111(6):1524–1533. doi: 10.1016/s0016-5085(96)70014-8. [DOI] [PubMed] [Google Scholar]
  301. Wirth H. P., Yang M., Karita M., Blaser M. J. Expression of the human cell surface glycoconjugates Lewis x and Lewis y by Helicobacter pylori isolates is related to cagA status. Infect Immun. 1996 Nov;64(11):4598–4605. doi: 10.1128/iai.64.11.4598-4605.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  302. Witteman E. M., Hopman W. P., Becx M. C., De Koning R. W., Tytgat G. N., Janssen A. J., Jansen J. B. Short report: smoking habits and the acquisition of metronidazole resistance in patients with Helicobacter pylori-related gastritis. Aliment Pharmacol Ther. 1993 Dec;7(6):683–687. doi: 10.1111/j.1365-2036.1993.tb00151.x. [DOI] [PubMed] [Google Scholar]
  303. Worst D. J., Otto B. R., de Graaff J. Iron-repressible outer membrane proteins of Helicobacter pylori involved in heme uptake. Infect Immun. 1995 Oct;63(10):4161–4165. doi: 10.1128/iai.63.10.4161-4165.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  304. Worst D. J., Sparrius M., Kuipers E. J., Kusters J. G., de Graaff J. Human serum antibody response against iron-repressible outer membrane proteins of Helicobacter pylori. FEMS Microbiol Lett. 1996 Oct 15;144(1):29–32. doi: 10.1111/j.1574-6968.1996.tb08504.x. [DOI] [PubMed] [Google Scholar]
  305. Wotherspoon A. C., Doglioni C., Diss T. C., Pan L., Moschini A., de Boni M., Isaacson P. G. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993 Sep 4;342(8871):575–577. doi: 10.1016/0140-6736(93)91409-f. [DOI] [PubMed] [Google Scholar]
  306. Wotherspoon A. C., Ortiz-Hidalgo C., Falzon M. R., Isaacson P. G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991 Nov 9;338(8776):1175–1176. doi: 10.1016/0140-6736(91)92035-z. [DOI] [PubMed] [Google Scholar]
  307. Wu J. C., Liu G. L., Zhang Z. H., Mou Y. L., Chen Q. A., Wu J. C., Yang S. L. 15NH4+ excretion test: a new method for detection of Helicobacter pylori infection. J Clin Microbiol. 1992 Jan;30(1):181–184. doi: 10.1128/jcm.30.1.181-184.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  308. Xiang Z., Bugnoli M., Ponzetto A., Morgando A., Figura N., Covacci A., Petracca R., Pennatini C., Censini S., Armellini D. Detection in an enzyme immunoassay of an immune response to a recombinant fragment of the 128 kilodalton protein (CagA) of Helicobacter pylori. Eur J Clin Microbiol Infect Dis. 1993 Oct;12(10):739–745. doi: 10.1007/BF02098460. [DOI] [PubMed] [Google Scholar]
  309. Yasunaga Y., Shinomura Y., Kanayama S., Yabu M., Nakanishi T., Miyazaki Y., Murayama Y., Bonilla-Palacios J. J., Matsuzawa Y. Improved fold width and increased acid secretion after eradication of the organism in Helicobacter pylori associated enlarged fold gastritis. Gut. 1994 Nov;35(11):1571–1574. doi: 10.1136/gut.35.11.1571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  310. Yoshida N., Yoshikawa T., Iinuma S., Arai M., Takenaka S., Sakamoto K., Miyajima T., Nakamura Y., Yagi N., Naito Y. Rebamipide protects against activation of neutrophils by Helicobacter pylori. Dig Dis Sci. 1996 Jun;41(6):1139–1144. doi: 10.1007/BF02088229. [DOI] [PubMed] [Google Scholar]
  311. Yousfi M. M., Reddy R., Osato M. S., Graham D. Y. Culture of Helicobacter pylori: effect of preimmersion of biopsy forceps in formalin. Helicobacter. 1996 Mar;1(1):62–64. doi: 10.1111/j.1523-5378.1996.tb00010.x. [DOI] [PubMed] [Google Scholar]
  312. de Boer W. A., van Etten R. J., Schade R. W., Ouwehand M. E., Schneeberger P. M., Tytgat G. N. 4-day lansoprazole quadruple therapy: a highly effective cure for Helicobacter pylori infection. Am J Gastroenterol. 1996 Sep;91(9):1778–1782. [PubMed] [Google Scholar]
  313. de Boer W., Driessen W., Jansz A., Tytgat G. Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection. Lancet. 1995 Apr 1;345(8953):817–820. doi: 10.1016/s0140-6736(95)92962-2. [DOI] [PubMed] [Google Scholar]
  314. de Cothi G. A., Newbold K. M., O'Connor H. J. Campylobacter-like organisms and heterotopic gastric mucosa in Meckel's diverticula. J Clin Pathol. 1989 Feb;42(2):132–134. doi: 10.1136/jcp.42.2.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  315. el-Zaatari F. A., Nguyen A. M., Genta R. M., Klein P. D., Graham D. Y. Determination of Helicobacter pylori status by reverse transcription-polymerase chain reaction. Comparison with urea breath test. Dig Dis Sci. 1995 Jan;40(1):109–113. doi: 10.1007/BF02063952. [DOI] [PubMed] [Google Scholar]
  316. el-Zimaity H. M., Graham D. Y., al-Assi M. T., Malaty H., Karttunen T. J., Graham D. P., Huberman R. M., Genta R. M. Interobserver variation in the histopathological assessment of Helicobacter pylori gastritis. Hum Pathol. 1996 Jan;27(1):35–41. doi: 10.1016/s0046-8177(96)90135-5. [DOI] [PubMed] [Google Scholar]
  317. el-Zimaity H. M., al-Assi M. T., Genta R. M., Graham D. Y. Confirmation of successful therapy of Helicobacter pylori infection: number and site of biopsies or a rapid urease test. Am J Gastroenterol. 1995 Nov;90(11):1962–1964. [PubMed] [Google Scholar]
  318. van Zwet A. A., Thijs J. C., de Graaf B. Explanations for high rates of eradication with triple therapy using metronidazole in patients harboring metronidazole-resistant Helicobacter pylori strains. Antimicrob Agents Chemother. 1995 Jan;39(1):250–252. doi: 10.1128/aac.39.1.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  319. van der Ende A., Rauws E. A., Feller M., Mulder C. J., Tytgat G. N., Dankert J. Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease. Gastroenterology. 1996 Sep;111(3):638–647. doi: 10.1053/gast.1996.v111.pm8780568. [DOI] [PubMed] [Google Scholar]
  320. van der Hulst R. W., Keller J. J., Rauws E. A., Tytgat G. N. Treatment of Helicobacter pylori infection: a review of the world literature. Helicobacter. 1996 Mar;1(1):6–19. doi: 10.1111/j.1523-5378.1996.tb00003.x. [DOI] [PubMed] [Google Scholar]

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