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. 1998 Nov;53(11):984–988. doi: 10.1136/thx.53.11.984

Methodology of bronchial responsiveness

S Chinn 1
PMCID: PMC1745109  PMID: 10193400

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Selected References

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  1. Abramson M. J., Saunders N. A., Hensley M. J. Analysis of bronchial reactivity in epidemiological studies. Thorax. 1990 Dec;45(12):924–929. doi: 10.1136/thx.45.12.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaupré A., Malo J. L. Histamine dose-response curves in asthma: relevance of the distinction between PC20 and reactivity in characterising clinical state. Thorax. 1981 Oct;36(10):731–736. doi: 10.1136/thx.36.10.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Britton J., Mortagy A., Tattersfield A. Histamine challenge testing: comparison of three methods. Thorax. 1986 Feb;41(2):128–132. doi: 10.1136/thx.41.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Burney P. G., Britton J. R., Chinn S., Tattersfield A. E., Papacosta A. O., Kelson M. C., Anderson F., Corfield D. R. Descriptive epidemiology of bronchial reactivity in an adult population: results from a community study. Thorax. 1987 Jan;42(1):38–44. doi: 10.1136/thx.42.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Burrows B., Sears M. R., Flannery E. M., Herbison G. P., Holdaway M. D. Relationships of bronchial responsiveness assessed by methacholine to serum IgE, lung function, symptoms, and diagnoses in 11-year-old New Zealand children. J Allergy Clin Immunol. 1992 Sep;90(3 Pt 1):376–385. doi: 10.1016/s0091-6749(05)80018-1. [DOI] [PubMed] [Google Scholar]
  6. Chinn S., Arossa W. A., Jarvis D. L., Luczynska C. M., Burney P. G. Variation in nebulizer aerosol output and weight output from the Mefar dosimeter: implications for multicentre studies. Eur Respir J. 1997 Feb;10(2):452–456. doi: 10.1183/09031936.97.10020452. [DOI] [PubMed] [Google Scholar]
  7. Chinn S., Britton J. R., Burney P. G., Tattersfield A. E., Papacosta A. O. Estimation and repeatability of the response to inhaled histamine in a community survey. Thorax. 1987 Jan;42(1):45–52. doi: 10.1136/thx.42.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chinn S., Burney P. G., Britton J. R., Tattersfield A. E., Higgins B. G. Comparison of PD20 with two alternative measures of response to histamine challenge in epidemiological studies. Eur Respir J. 1993 May;6(5):670–679. [PubMed] [Google Scholar]
  9. Chinn S., Burney P., Jarvis D., Luczynska C. Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). Eur Respir J. 1997 Nov;10(11):2495–2501. doi: 10.1183/09031936.97.10112495. [DOI] [PubMed] [Google Scholar]
  10. Chinn S., Jarvis D., Luczynska C., Burney P. Individual allergens as risk factors for bronchial responsiveness in young adults. Thorax. 1998 Aug;53(8):662–667. doi: 10.1136/thx.53.8.662. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cockcroft D. W., Berscheid B. A., Murdock K. Y. Measurement of responsiveness to inhaled histamine using FEV1: comparison of PC20 and threshold. Thorax. 1983 Jul;38(7):523–526. doi: 10.1136/thx.38.7.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Cockcroft D. W., Berscheid B. A., Murdock K. Y. Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest. 1983 May;83(5):751–754. doi: 10.1378/chest.83.5.751. [DOI] [PubMed] [Google Scholar]
  13. Cockcroft D. W., Berscheid B. A. Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine. Thorax. 1983 Jan;38(1):55–61. doi: 10.1136/thx.38.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. doi: 10.1111/j.1365-2222.1977.tb01448.x. [DOI] [PubMed] [Google Scholar]
  15. Cook D. G., Strachan D. P. Parental smoking, bronchial reactivity and peak flow variability in children. Thorax. 1998 Apr;53(4):295–301. doi: 10.1136/thx.53.4.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Cook D. J., Sackett D. L., Spitzer W. O. Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis. J Clin Epidemiol. 1995 Jan;48(1):167–171. doi: 10.1016/0895-4356(94)00172-m. [DOI] [PubMed] [Google Scholar]
  17. Dehaut P., Rachiele A., Martin R. R., Malo J. L. Histamine dose-response curves in asthma: reproducibility and sensitivity of different indices to assess response. Thorax. 1983 Jul;38(7):516–522. doi: 10.1136/thx.38.7.516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Dennis J. H., Avery A. J., Walters E. H., Hendrick D. J. Calibration of aerosol output from the Mefar dosimeter: implications for epidemiological studies. Eur Respir J. 1992 Nov;5(10):1279–1282. [PubMed] [Google Scholar]
  19. Dennis J. H., Stenton S. C., Beach J. R., Avery A. J., Walters E. H., Hendrick D. J. Jet and ultrasonic nebuliser output: use of a new method for direct measurement of aerosol output. Thorax. 1990 Oct;45(10):728–732. doi: 10.1136/thx.45.10.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Enarson D. A., Schulzer M., Vedal S., Chan-Yeung M. Summarizing methacholine bronchoprovocation data in epidemiological surveys. Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):387–389. [PubMed] [Google Scholar]
  21. Hamm H., Light R. W. The pleura: the outer space of pulmonary medicine. Eur Respir J. 1997 Jan;10(1):2–3. doi: 10.1183/09031936.97.10010002. [DOI] [PubMed] [Google Scholar]
  22. Juniper E. F., Frith P. A., Dunnett C., Cockcroft D. W., Hargreave F. E. Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax. 1978 Dec;33(6):705–710. doi: 10.1136/thx.33.6.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Malo J. L., Cartier A., Pineau L., Gagnon G., Martin R. R. Slope of the dose-response curve to inhaled histamine and methacholine and PC20 in subjects with symptoms of airway hyperexcitability and in normal subjects. Am Rev Respir Dis. 1985 Sep;132(3):644–647. doi: 10.1164/arrd.1985.132.3.644. [DOI] [PubMed] [Google Scholar]
  24. Neukirch F., Cartier A. Mesure de l'hyperréactivité bronchique en épidémiologie. Rev Mal Respir. 1994;11(2):101–109. [PubMed] [Google Scholar]
  25. O'Connor G., Sparrow D., Taylor D., Segal M., Weiss S. Analysis of dose-response curves to methacholine. An approach suitable for population studies. Am Rev Respir Dis. 1987 Dec;136(6):1412–1417. doi: 10.1164/ajrccm/136.6.1412. [DOI] [PubMed] [Google Scholar]
  26. Orehek J., Gayrard P., Smith A. P., Grimaud C., Charpin J. Airway response to carbachol in normal and asthmatic subjects: distinction between bronchial sensitivity and reactivity. Am Rev Respir Dis. 1977 Jun;115(6):937–943. doi: 10.1164/arrd.1977.115.6.937. [DOI] [PubMed] [Google Scholar]
  27. Peat J. K., Unger W. R., Combe D. Measuring changes in logarithmic data, with special reference to bronchial responsiveness. J Clin Epidemiol. 1994 Oct;47(10):1099–1108. doi: 10.1016/0895-4356(94)90096-5. [DOI] [PubMed] [Google Scholar]
  28. Rijcken B., Schouten J. P., Weiss S. T., Meinesz A. F., de Vries K., van der Lende R. The distribution of bronchial responsiveness to histamine in symptomatic and in asymptomatic subjects. A population-based analysis of various indices of responsiveness. Am Rev Respir Dis. 1989 Sep;140(3):615–623. doi: 10.1164/ajrccm/140.3.615. [DOI] [PubMed] [Google Scholar]
  29. Rubinfeld A. R., Pain M. C. Relationship between bronchial reactivity, airway caliber, and severity of asthma. Am Rev Respir Dis. 1977 Mar;115(3):381–387. doi: 10.1164/arrd.1977.115.3.381. [DOI] [PubMed] [Google Scholar]
  30. Sterk P. J., Bel E. H. Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowing. Eur Respir J. 1989 Mar;2(3):267–274. [PubMed] [Google Scholar]
  31. Sterk P. J., Daniel E. E., Zamel N., Hargreave F. E. Limited bronchoconstriction to methacholine using partial flow-volume curves in nonasthmatic subjects. Am Rev Respir Dis. 1985 Aug;132(2):272–277. doi: 10.1164/arrd.1985.132.2.272. [DOI] [PubMed] [Google Scholar]
  32. Sterk P. J., Fabbri L. M., Quanjer P. H., Cockcroft D. W., O'Byrne P. M., Anderson S. D., Juniper E. F., Malo J. L. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl. 1993 Mar;16:53–83. [PubMed] [Google Scholar]
  33. Sunyer J., Muñoz A. Concentrations of methacholine for bronchial responsiveness according to symptoms, smoking and immunoglobulin E in a population-based study in Spain. Spanish Group of the European Asthma Study. Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1273–1279. doi: 10.1164/ajrccm.153.4.8616553. [DOI] [PubMed] [Google Scholar]
  34. Verlato G., Cerveri I., Villani A., Pasquetto M., Ferrari M., Fanfulla F., Zanolin E., Rijcken B., de Marco R. Evaluation of methacholine dose-response curves by linear and exponential mathematical models: goodness-of-fit and validity of extrapolation. Eur Respir J. 1996 Mar;9(3):506–511. doi: 10.1183/09031936.96.09030506. [DOI] [PubMed] [Google Scholar]
  35. Ward R. J., Reid D. W., Walters E. H. Variation in nebulizer output and weight output from Mefar dosimeter: implications for multicentre studies. Eur Respir J. 1997 Oct;10(10):2436–2437. doi: 10.1183/09031936.97.10102436. [DOI] [PubMed] [Google Scholar]
  36. Woolcock A. J., Salome C. M., Yan K. The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am Rev Respir Dis. 1984 Jul;130(1):71–75. doi: 10.1164/arrd.1984.130.1.71. [DOI] [PubMed] [Google Scholar]
  37. Yan K., Salome C., Woolcock A. J. Rapid method for measurement of bronchial responsiveness. Thorax. 1983 Oct;38(10):760–765. doi: 10.1136/thx.38.10.760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. de Pee S., Timmers M. C., Hermans J., Duiverman E. J., Sterk P. J. Comparison of maximal airway narrowing to methacholine between children and adults. Eur Respir J. 1991 Apr;4(4):421–428. [PubMed] [Google Scholar]

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