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. 2004 Nov;59(11):981–985. doi: 10.1136/thx.2003.018861

Type of wine and risk of lung cancer: a case-control study in Spain

A Ruano-Ravina 1, A Figueiras 1, J Barros-Dios 1
PMCID: PMC1746864  PMID: 15516476

Abstract

Background: Few epidemiological studies have examined the effect of wine on the risk of lung cancer. A study was therefore undertaken to estimate the effect of wine consumption, both overall and by type of wine, on the risk of developing lung cancer.

Methods: A hospital based case-control study was conducted on 319 subjects (132 cases, 187 controls) in 1999–2000. All subjects were interviewed about their lifestyles with particular reference to alcohol consumption and tobacco use. The results were analysed using non-parametric logistic regression. The main outcome measure was the risk of lung cancer associated with consumption of wine and its individual types.

Results: A very slight but significant association was observed between the risk of lung cancer and white wine consumption (odds ratio (OR) 1.20 for each daily glass). Red wine consumption, on the other hand, had an OR of 0.43 (95% CI 0.19 to 0.96), with each daily glass of red wine having an inverse association with the development of lung cancer (OR 0.87 (95% CI 0.77 to 0.99)). There was no apparent association between lung cancer and consumption of beer or spirits.

Conclusions: These results suggest that the consumption of red wine is negatively associated with the development of lung cancer. Further studies are needed to test this finding in cancer induced laboratory animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahrendt S. A., Chow J. T., Yang S. C., Wu L., Zhang M. J., Jen J., Sidransky D. Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer. Cancer Res. 2000 Jun 15;60(12):3155–3159. [PubMed] [Google Scholar]
  2. Ahrens W., Merletti F. A standard tool for the analysis of occupational lung cancer in epidemiologic studies. Int J Occup Environ Health. 1998 Oct-Dec;4(4):236–240. doi: 10.1179/oeh.1998.4.4.236. [DOI] [PubMed] [Google Scholar]
  3. Bandera E. V., Freudenheim J. L., Graham S., Marshall J. R., Haughey B. P., Swanson M., Brasure J., Wilkinson G. Alcohol consumption and lung cancer in white males. Cancer Causes Control. 1992 Jul;3(4):361–369. doi: 10.1007/BF00146890. [DOI] [PubMed] [Google Scholar]
  4. Bandera E. V., Freudenheim J. L., Marshall J. R., Zielezny M., Priore R. L., Brasure J., Baptiste M., Graham S. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States) Cancer Causes Control. 1997 Nov;8(6):828–840. doi: 10.1023/a:1018456127018. [DOI] [PubMed] [Google Scholar]
  5. Bandera E. V., Freudenheim J. L., Vena J. E. Alcohol consumption and lung cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev. 2001 Aug;10(8):813–821. [PubMed] [Google Scholar]
  6. Boffetta P., Ye W., Adami H. O., Mucci L. A., Nyrén O. Risk of cancers of the lung, head and neck in patients hospitalized for alcoholism in Sweden. Br J Cancer. 2001 Sep 1;85(5):678–682. doi: 10.1054/bjoc.2001.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Brenner H., Blettner M. Controlling for continuous confounders in epidemiologic research. Epidemiology. 1997 Jul;8(4):429–434. [PubMed] [Google Scholar]
  8. Brenner H., Blettner M. Controlling for continuous confounders in epidemiologic research. Epidemiology. 1997 Jul;8(4):429–434. [PubMed] [Google Scholar]
  9. Carpenter C. L., Morgenstern H., London S. J. Alcoholic beverage consumption and lung cancer risk among residents of Los Angeles County. J Nutr. 1998 Apr;128(4):694–700. doi: 10.1093/jn/128.4.694. [DOI] [PubMed] [Google Scholar]
  10. De Stefani E., Correa P., Fierro L., Fontham E. T., Chen V., Zavala D. The effect of alcohol on the risk of lung cancer in Uruguay. Cancer Epidemiol Biomarkers Prev. 1993 Jan-Feb;2(1):21–26. [PubMed] [Google Scholar]
  11. Djoussé Luc, Dorgan Joanne F., Zhang Yuqing, Schatzkin Arthur, Hood Maggie, D'Agostino Ralph B., Copenhafer Donna L., Kreger Bernard E., Ellison R. Curtis. Alcohol consumption and risk of lung cancer: the Framingham Study. J Natl Cancer Inst. 2002 Dec 18;94(24):1877–1882. doi: 10.1093/jnci/94.24.1877. [DOI] [PubMed] [Google Scholar]
  12. Figueiras A., Cadarso-Suárez C. Application of nonparametric models for calculating odds ratios and their confidence intervals for continuous exposures. Am J Epidemiol. 2001 Aug 1;154(3):264–275. doi: 10.1093/aje/154.3.264. [DOI] [PubMed] [Google Scholar]
  13. Freudenheim Jo L., Ram Malathi, Nie Jing, Muti Paola, Trevisan Maurizio, Shields Peter G., Bandera Elisa V., Campbell Lucy A., McCann Susan E., Schunemann Holger J. Lung cancer in humans is not associated with lifetime total alcohol consumption or with genetic variation in alcohol dehydrogenase 3 (ADH3). J Nutr. 2003 Nov;133(11):3619–3624. doi: 10.1093/jn/133.11.3619. [DOI] [PubMed] [Google Scholar]
  14. Grønbaek M., Becker U., Johansen D., Tønnesen H., Jensen G., Sørensen T. I. Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract. BMJ. 1998 Sep 26;317(7162):844–847. doi: 10.1136/bmj.317.7162.844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hecht S. S. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst. 1999 Jul 21;91(14):1194–1210. doi: 10.1093/jnci/91.14.1194. [DOI] [PubMed] [Google Scholar]
  16. Jang M., Cai L., Udeani G. O., Slowing K. V., Thomas C. F., Beecher C. W., Fong H. H., Farnsworth N. R., Kinghorn A. D., Mehta R. G. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218–220. doi: 10.1126/science.275.5297.218. [DOI] [PubMed] [Google Scholar]
  17. Knekt P., Järvinen R., Seppänen R., Hellövaara M., Teppo L., Pukkala E., Aromaa A. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol. 1997 Aug 1;146(3):223–230. doi: 10.1093/oxfordjournals.aje.a009257. [DOI] [PubMed] [Google Scholar]
  18. Korte Jeffrey E., Brennan Paul, Henley S. Jane, Boffetta Paolo. Dose-specific meta-analysis and sensitivity analysis of the relation between alcohol consumption and lung cancer risk. Am J Epidemiol. 2002 Mar 15;155(6):496–506. doi: 10.1093/aje/155.6.496. [DOI] [PubMed] [Google Scholar]
  19. Leffondré Karen, Abrahamowicz Michal, Siemiatycki Jack, Rachet Bernard. Modeling smoking history: a comparison of different approaches. Am J Epidemiol. 2002 Nov 1;156(9):813–823. doi: 10.1093/aje/kwf122. [DOI] [PubMed] [Google Scholar]
  20. Mollerup S., Ovrebø S., Haugen A. Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells. Int J Cancer. 2001 Apr 1;92(1):18–25. [PubMed] [Google Scholar]
  21. Männistö Satu, Smith-Warner Stephanie A., Spiegelman Donna, Albanes Demetrius, Anderson Kristin, van den Brandt Piet A., Cerhan James R., Colditz Graham, Feskanich Diane, Freudenheim Jo L. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):40–48. doi: 10.1158/1055-9965.epi-038-3. [DOI] [PubMed] [Google Scholar]
  22. Parkin D. M., Pisani P., Lopez A. D., Masuyer E. At least one in seven cases of cancer is caused by smoking. Global estimates for 1985. Int J Cancer. 1994 Nov 15;59(4):494–504. doi: 10.1002/ijc.2910590411. [DOI] [PubMed] [Google Scholar]
  23. Potter J. D., Sellers T. A., Folsom A. R., McGovern P. G. Alcohol, beer, and lung cancer in postmenopausal women. The Iowa Women's Health Study. Ann Epidemiol. 1992 Sep;2(5):587–595. doi: 10.1016/1047-2797(92)90003-9. [DOI] [PubMed] [Google Scholar]
  24. Prescott E., Grønbaek M., Becker U., Sørensen T. I. Alcohol intake and the risk of lung cancer: influence of type of alcoholic beverage. Am J Epidemiol. 1999 Mar 1;149(5):463–470. doi: 10.1093/oxfordjournals.aje.a009834. [DOI] [PubMed] [Google Scholar]
  25. Rachtan Jadwiga. Alcoholic beverages consumption and lung cancer cell types among women in Poland. Lung Cancer. 2002 Feb;35(2):119–127. doi: 10.1016/s0169-5002(01)00331-2. [DOI] [PubMed] [Google Scholar]
  26. Ruano-Ravina A., Figueiras A., Montes-Martínez A., Barros-Dios J. M. Dose-response relationship between tobacco and lung cancer: new findings. Eur J Cancer Prev. 2003 Aug;12(4):257–263. doi: 10.1097/00008469-200308000-00003. [DOI] [PubMed] [Google Scholar]
  27. Ruano-Ravina Alberto, Figueiras Adolfo, Barreiro-Carracedo María Amparo, Barros-Dios Juan. Occupation and smoking as risk factors for lung cancer: a population-based case-control study. Am J Ind Med. 2003 Feb;43(2):149–155. doi: 10.1002/ajim.10171. [DOI] [PubMed] [Google Scholar]
  28. Ruano-Ravina Alberto, Figueiras Adolfo, Dosil-Diaz Olga, Barreiro-Carracedo Ana, Barros-Dios Juan Miguel. A population-based case-control study on fruit and vegetable intake and lung cancer: a paradox effect? Nutr Cancer. 2002;43(1):47–51. doi: 10.1207/S15327914NC431_5. [DOI] [PubMed] [Google Scholar]
  29. Woodson K., Albanes D., Tangrea J. A., Rautalahti M., Virtamo J., Taylor P. R. Association between alcohol and lung cancer in the alpha-tocopherol, beta-carotene cancer prevention study in Finland. Cancer Causes Control. 1999 Jun;10(3):219–226. doi: 10.1023/a:1008911624785. [DOI] [PubMed] [Google Scholar]
  30. Zang E. A., Wynder E. L. Reevaluation of the confounding effect of cigarette smoking on the relationship between alcohol use and lung cancer risk, with larynx cancer used as a positive control. Prev Med. 2001 Apr;32(4):359–370. doi: 10.1006/pmed.2000.0818. [DOI] [PubMed] [Google Scholar]
  31. Ziegler R. G., Mayne S. T., Swanson C. A. Nutrition and lung cancer. Cancer Causes Control. 1996 Jan;7(1):157–177. doi: 10.1007/BF00115646. [DOI] [PubMed] [Google Scholar]

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