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. 2005 Jan;60(1):45–49. doi: 10.1136/thx.2004.021154

Frequent use of chemical household products is associated with persistent wheezing in pre-school age children

A Sherriff 1, A Farrow 1, J Golding 1, A the 1, J Henderson 1
PMCID: PMC1747149  PMID: 15618582

Abstract

Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of chemical based products in the prenatal period and patterns of wheeze in early childhood.

Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 chemical based domestic products was determined from questionnaires completed by women during pregnancy and a total chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children.

Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of domestic chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (<10th centile) (adjusted OR 2.3 (95% CI 1.2 to 4.4)).

Conclusion: These findings suggest that frequent use of chemical based products in the prenatal period is associated with persistent wheezing in young children. Follow up of this cohort is underway to determine whether TCB is associated with wheezing, asthma, and atopy at later stages in childhood.

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Selected References

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  1. Anderson H. R., Butland B. K., Strachan D. P. Trends in prevalence and severity of childhood asthma. BMJ. 1994 Jun 18;308(6944):1600–1604. doi: 10.1136/bmj.308.6944.1600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arif A. A., Whitehead L. W., Delclos G. L., Tortolero S. R., Lee E. S. Prevalence and risk factors of work related asthma by industry among United States workers: data from the third national health and nutrition examination survey (1988-94). Occup Environ Med. 2002 Aug;59(8):505–511. doi: 10.1136/oem.59.8.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Becher R., Hongslo J. K., Jantunen M. J., Dybing E. Environmental chemicals relevant for respiratory hypersensitivity: the indoor environment. Toxicol Lett. 1996 Aug;86(2-3):155–162. doi: 10.1016/0378-4274(96)03685-5. [DOI] [PubMed] [Google Scholar]
  4. Burr M. L., Butland B. K., King S., Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child. 1989 Oct;64(10):1452–1456. doi: 10.1136/adc.64.10.1452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Delfino Ralph J. Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Environ Health Perspect. 2002 Aug;110 (Suppl 4):573–589. doi: 10.1289/ehp.02110s4573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dezateux C., Stocks J., Dundas I., Fletcher M. E. Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma. Am J Respir Crit Care Med. 1999 Feb;159(2):403–410. doi: 10.1164/ajrccm.159.2.9712029. [DOI] [PubMed] [Google Scholar]
  7. Goldenberg Hannah B., McCool Tera L., Weiser Jeffrey N. Cross-reactivity of human immunoglobulin G2 recognizing phosphorylcholine and evidence for protection against major bacterial pathogens of the human respiratory tract. J Infect Dis. 2004 Aug 31;190(7):1254–1263. doi: 10.1086/424517. [DOI] [PubMed] [Google Scholar]
  8. Golding J., Pembrey M., Jones R., ALSPAC Study Team ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr Perinat Epidemiol. 2001 Jan;15(1):74–87. doi: 10.1046/j.1365-3016.2001.00325.x. [DOI] [PubMed] [Google Scholar]
  9. Karjalainen A., Martikainen R., Karjalainen J., Klaukka T., Kurppa K. Excess incidence of asthma among Finnish cleaners employed in different industries. Eur Respir J. 2002 Jan;19(1):90–95. doi: 10.1183/09031936.02.00201002. [DOI] [PubMed] [Google Scholar]
  10. Kogevinas M., Antó J. M., Sunyer J., Tobias A., Kromhout H., Burney P. Occupational asthma in Europe and other industrialised areas: a population-based study. European Community Respiratory Health Survey Study Group. Lancet. 1999 May 22;353(9166):1750–1754. doi: 10.1016/s0140-6736(98)07397-8. [DOI] [PubMed] [Google Scholar]
  11. Lemus R., Abdelghani A. A., Akers T. G., Horner W. E. Potential health risks from exposure to indoor formaldehyde. Rev Environ Health. 1998 Jan-Jun;13(1-2):91–98. [PubMed] [Google Scholar]
  12. Lewis S., Butland B., Strachan D., Bynner J., Richards D., Butler N., Britton J. Study of the aetiology of wheezing illness at age 16 in two national British birth cohorts. Thorax. 1996 Jul;51(7):670–676. doi: 10.1136/thx.51.7.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Martinez F. D., Wright A. L., Taussig L. M., Holberg C. J., Halonen M., Morgan W. J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995 Jan 19;332(3):133–138. doi: 10.1056/NEJM199501193320301. [DOI] [PubMed] [Google Scholar]
  14. Medina-Ramón M., Zock J. P., Kogevinas M., Sunyer J., Antó J. M. Asthma symptoms in women employed in domestic cleaning: a community based study. Thorax. 2003 Nov;58(11):950–954. doi: 10.1136/thorax.58.11.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Millqvist E., Bengtsson U., Löwhagen O. Provocations with perfume in the eyes induce airway symptoms in patients with sensory hyperreactivity. Allergy. 1999 May;54(5):495–499. doi: 10.1034/j.1398-9995.1999.00031.x. [DOI] [PubMed] [Google Scholar]
  16. Murphy J. F. Asthma: increasing despite advances in therapy. Ir Med J. 1998 May-Jun;91(3):76–76. [PubMed] [Google Scholar]
  17. Nielsen J., Bach E. Work-related eye symptoms and respiratory symptoms in female cleaners. Occup Med (Lond) 1999 Jul;49(5):291–297. doi: 10.1093/occmed/49.5.291. [DOI] [PubMed] [Google Scholar]
  18. Ninan T. K., Russell G. Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ. 1992 Apr 4;304(6831):873–875. doi: 10.1136/bmj.304.6831.873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Norbäck D., Björnsson E., Janson C., Widström J., Boman G. Asthmatic symptoms and volatile organic compounds, formaldehyde, and carbon dioxide in dwellings. Occup Environ Med. 1995 Jun;52(6):388–395. doi: 10.1136/oem.52.6.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Omran M., Russell G. Continuing increase in respiratory symptoms and atopy in Aberdeen schoolchildren. BMJ. 1996 Jan 6;312(7022):34–34. doi: 10.1136/bmj.312.7022.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Peat J. K., van den Berg R. H., Green W. F., Mellis C. M., Leeder S. R., Woolcock A. J. Changing prevalence of asthma in Australian children. BMJ. 1994 Jun 18;308(6944):1591–1596. doi: 10.1136/bmj.308.6944.1591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Ross D. J., Keynes H. L., McDonald J. C. SWORD '97: surveillance of work-related and occupational respiratory disease in the UK. Occup Med (Lond) 1998 Nov;48(8):481–485. doi: 10.1093/occmed/48.8.481. [DOI] [PubMed] [Google Scholar]
  23. Sherriff A., Peters T. J., Henderson J., Strachan D., ALSPAC Study Team. Avon Longitudinal Study of Parents and Children Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol. 2001 Dec;30(6):1473–1484. doi: 10.1093/ije/30.6.1473. [DOI] [PubMed] [Google Scholar]
  24. Sly R. M. Changing prevalence of allergic rhinitis and asthma. Ann Allergy Asthma Immunol. 1999 Mar;82(3):233–252. doi: 10.1016/S1081-1206(10)62603-8. [DOI] [PubMed] [Google Scholar]
  25. Smedje G., Norbäck D., Edling C. Asthma among secondary schoolchildren in relation to the school environment. Clin Exp Allergy. 1997 Nov;27(11):1270–1278. [PubMed] [Google Scholar]
  26. Smedje G., Norbäck D. Incidence of asthma diagnosis and self-reported allergy in relation to the school environment--a four-year follow-up study in schoolchildren. Int J Tuberc Lung Dis. 2001 Nov;5(11):1059–1066. [PubMed] [Google Scholar]
  27. Stick S. M., Burton P. R., Gurrin L., Sly P. D., LeSouëf P. N. Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants. Lancet. 1996 Oct 19;348(9034):1060–1064. doi: 10.1016/s0140-6736(96)04446-7. [DOI] [PubMed] [Google Scholar]
  28. Venn A. J., Cooper M., Antoniak M., Laughlin C., Britton J., Lewis S. A. Effects of volatile organic compounds, damp, and other environmental exposures in the home on wheezing illness in children. Thorax. 2003 Nov;58(11):955–960. doi: 10.1136/thorax.58.11.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Zock J. P., Kogevinas M., Sunyer J., Almar E., Muniozguren N., Payo F., Sánchez J. L., Antó J. M., Spanish working group of the European Community Respiratory Health Survey Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners. Scand J Work Environ Health. 2001 Feb;27(1):76–81. doi: 10.5271/sjweh.590. [DOI] [PubMed] [Google Scholar]
  30. Zock J. P., Kogevinas M., Sunyer J., Jarvis D., Torén K., Antó J. M., European Community Respiratory Health Survey Asthma characteristics in cleaning workers, workers in other risk jobs and office workers. Eur Respir J. 2002 Sep;20(3):679–685. doi: 10.1183/09031936.02.00279702. [DOI] [PubMed] [Google Scholar]

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