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. 1987 Feb;31(2):354–356. doi: 10.1128/aac.31.2.354

Single-dose ciprofloxacin at 100 versus 250 mg for treatment of uncomplicated urinary tract infections in women.

F Garlando, S Rietiker, M G Täuber, M Flepp, B Meier, R Lüthy
PMCID: PMC174727  PMID: 3551837

Abstract

Two single-dose regimens of ciprofloxacin, 100 and 250 mg, were compared in the treatment of uncomplicated urinary tract infections in women. Cure rates 5 days after therapy did not significantly differ, being 16 of 19 (84%) with the 100-mg dose and 17 of 19 (89%) with the 250-mg dose. Ciprofloxacin was well tolerated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acar J. F. Effective treatment of urinary tract infections. Infection. 1980;Suppl 1:70–74. doi: 10.1007/BF01644939. [DOI] [PubMed] [Google Scholar]
  2. Bailey R. R., Abbott G. D. Treatment of urinary tract infection with a single dose of trimethoprim-sulfamethoxazole. Can Med Assoc J. 1978 Mar 4;118(5):551–552. [PMC free article] [PubMed] [Google Scholar]
  3. Bailey R. R., Keenan T. D., Eliott J. C., Peddie B. A., Bishop V. Treatment of bacterial cystitis with a single dose of trimethoprim, co-trimoxazole or amoxycillin compared with a course of trimethoprim. N Z Med J. 1985 May 22;98(779):387–389. [PubMed] [Google Scholar]
  4. Brumfitt W., Faiers M. C., Franklin I. N. The treatment of urinary infection by means of a single dose of cephaloridine. Postgrad Med J. 1970 Oct;(Suppl):65–69. [PubMed] [Google Scholar]
  5. Dickreuter W., Berger C. Einmaldosis versus 5-Tage-Cotrimoxazol-Therapie akuter symptomatischer Harnweginfekte bei Frauen. Eine prospektive randomisierte Studie. Geburtshilfe Frauenheilkd. 1984 Dec;44(12):803–807. doi: 10.1055/s-2008-1036523. [DOI] [PubMed] [Google Scholar]
  6. Fang L. S., Tolkoff-Rubin N. E., Rubin R. H. Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic. N Engl J Med. 1978 Feb 23;298(8):413–416. doi: 10.1056/NEJM197802232980802. [DOI] [PubMed] [Google Scholar]
  7. Gonzalez M. A., Uribe F., Moisen S. D., Fuster A. P., Selen A., Welling P. G., Painter B. Multiple-dose pharmacokinetics and safety of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother. 1984 Nov;26(5):741–744. doi: 10.1128/aac.26.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gossius G., Vorland L. A randomised comparison of single-dose vs. three-day and ten-day therapy with trimethoprim-sulfamethoxazole for acute cystitis in women. Scand J Infect Dis. 1984;16(4):373–379. doi: 10.3109/00365548409073963. [DOI] [PubMed] [Google Scholar]
  9. Greenberg R. N., Sanders C. V., Lewis A. C., Marier R. L. Single-dose cefaclor therapy of urinary tract infection. Evaluation of antibody-coated bacteria test and C-reactive protein assay as predictors of cure. Am J Med. 1981 Nov;71(5):841–845. doi: 10.1016/0002-9343(81)90377-6. [DOI] [PubMed] [Google Scholar]
  10. Grüneberg R. N., Brumfitt W. Single-dose treatment of acute urinary tract infection: a controlled trial. Br Med J. 1967 Sep 9;3(5566):649–651. doi: 10.1136/bmj.3.5566.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hussain Z., Burchardt P., Biernat V., Bürger H. Einmaltherapie mit Gentamicin und gleichzeitige Lokalisation von Harnwegsinfekten. Dtsch Med Wochenschr. 1981 Oct 23;106(43):1420–1423. doi: 10.1055/s-2008-1070525. [DOI] [PubMed] [Google Scholar]
  12. Komaroff A. L. Acute dysuria in women. N Engl J Med. 1984 Feb 9;310(6):368–375. doi: 10.1056/NEJM198402093100607. [DOI] [PubMed] [Google Scholar]
  13. Ledergerber B., Bettex J. D., Joos B., Flepp M., Lüthy R. Effect of standard breakfast on drug absorption and multiple-dose pharmacokinetics of ciprofloxacin. Antimicrob Agents Chemother. 1985 Mar;27(3):350–352. doi: 10.1128/aac.27.3.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Prentice R. D., Wu L. R., Gehlbach S. H., Hanlon J. T., Clapp-Channing N. E., Finn A. L. Treatment of lower urinary tract infections with single-dose trimethoprim-sulfamethoxazole. J Fam Pract. 1985 Jun;20(6):551–557. [PubMed] [Google Scholar]
  15. Stamm W. E. Single-dose treatment of cystitis. JAMA. 1980 Aug 8;244(6):591–592. [PubMed] [Google Scholar]
  16. Wong E. S., McKevitt M., Running K., Counts G. W., Turck M., Stamm W. E. Management of recurrent urinary tract infections with patient-administered single-dose therapy. Ann Intern Med. 1985 Mar;102(3):302–307. doi: 10.7326/0003-4819-102-3-302. [DOI] [PubMed] [Google Scholar]

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