Abstract
Of 27 unique clinical isolates of methicillin-resistant Staphylococcus aureus, only 4 were homogeneously resistant, and all 4 produced little or no beta-lactamase. Among heterogeneously resistant strains, those most resistant to beta-lactam antibiotics produced the most beta-lactamase. Similar genes may regulate production of the low-affinity penicillin-binding protein and beta-lactamase.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beck W. D., Berger-Bächi B., Kayser F. H. Additional DNA in methicillin-resistant Staphylococcus aureus and molecular cloning of mec-specific DNA. J Bacteriol. 1986 Feb;165(2):373–378. doi: 10.1128/jb.165.2.373-378.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boyce J. M. Reevaluation of the ability of the standardized disk diffusion test to detect methicillin-resistant strains of Staphylococcus aureus. J Clin Microbiol. 1984 Jun;19(6):813–817. doi: 10.1128/jcm.19.6.813-817.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bulger R. J. A methicillin-resistant strain of Staphylococcus aureus. Clinical and laboratory experience. Ann Intern Med. 1967 Jul;67(1):81–89. doi: 10.7326/0003-4819-67-1-81. [DOI] [PubMed] [Google Scholar]
- Chabbert Y. A., Baudens J. G., Acar J. F., Gerbaud G. R. La résistance naturelle des staphylocoques à la méthicillin et l'oxacilline. Rev Fr Etud Clin Biol. 1965 May;10(5):495–506. [PubMed] [Google Scholar]
- Chambers H. F., Hartman B. J., Tomasz A. Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin. J Clin Invest. 1985 Jul;76(1):325–331. doi: 10.1172/JCI111965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cohen S., Gibson C. J., Sweeney H. M. Phenotypic suppression of methicillin resistance in Staphylococcus aureus by mutant noninducible penicillinase plasmids. J Bacteriol. 1972 Nov;112(2):682–689. doi: 10.1128/jb.112.2.682-689.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dyke K. G. Penicillinase production and intrinsic resistance to penicillins in methicillin-resistant cultures of Staphylococcus aureus. J Med Microbiol. 1969 Aug;2(3):261–278. doi: 10.1099/00222615-2-3-261. [DOI] [PubMed] [Google Scholar]
- Hamilton-Miller J. M. A comparison of the penicillinases from a methicillin-sensitive and froma a methicillin-resistant strain of Staphylococcus aureus. Guys Hosp Rep. 1970;119(2):155–171. [PubMed] [Google Scholar]
- Hartman B. J., Tomasz A. Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus. Antimicrob Agents Chemother. 1986 Jan;29(1):85–92. doi: 10.1128/aac.29.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartman B. J., Tomasz A. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J Bacteriol. 1984 May;158(2):513–516. doi: 10.1128/jb.158.2.513-516.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartman B., Tomasz A. Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus. Antimicrob Agents Chemother. 1981 May;19(5):726–735. doi: 10.1128/aac.19.5.726. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Imsande J. Genetic regulation of penicillinase synthesis in Gram-positive bacteria. Microbiol Rev. 1978 Mar;42(1):67–83. doi: 10.1128/mr.42.1.67-83.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kayser F. H. Methicillin-resistant staphylococci 1965-75. Lancet. 1975 Oct 4;2(7936):650–653. doi: 10.1016/s0140-6736(75)90129-4. [DOI] [PubMed] [Google Scholar]
- Lacey R. W., Stokes A. Studies on recently isolated cultures of methicillin-resistant Staphylococcus aureus. J Gen Microbiol. 1979 Oct;114(2):329–339. doi: 10.1099/00221287-114-2-329. [DOI] [PubMed] [Google Scholar]
- McDougal L. K., Thornsberry C. The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins. J Clin Microbiol. 1986 May;23(5):832–839. doi: 10.1128/jcm.23.5.832-839.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peacock J. E., Jr, Moorman D. R., Wenzel R. P., Mandell G. L. Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain. J Infect Dis. 1981 Dec;144(6):575–582. doi: 10.1093/infdis/144.6.575. [DOI] [PubMed] [Google Scholar]
- Reynaud A., Drugeon H. B., Chung S. S., Courtieu A. L. Expression de la résistance des staphylocoques à l'oxacilline et à la céfalotine. Pathol Biol (Paris) 1982 Jun;30(6 Pt 2):489–494. [PubMed] [Google Scholar]
- Rossi L., Tonin E., Cheng Y. R., Fontana R. Regulation of penicillin-binding protein activity: description of a methicillin-inducible penicillin-binding protein in Staphylococcus aureus. Antimicrob Agents Chemother. 1985 May;27(5):828–831. doi: 10.1128/aac.27.5.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schaefler S., Perry W., Jones D. Methicillin-resistant strains of Staphylococcus aureus phage type 92. Antimicrob Agents Chemother. 1979 Jan;15(1):74–80. doi: 10.1128/aac.15.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ubukata K., Yamashita N., Konno M. Occurrence of a beta-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci. Antimicrob Agents Chemother. 1985 May;27(5):851–857. doi: 10.1128/aac.27.5.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Utsui Y., Yokota T. Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1985 Sep;28(3):397–403. doi: 10.1128/aac.28.3.397. [DOI] [PMC free article] [PubMed] [Google Scholar]